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anti-Treacher Collins-Franceschetti Syndrome 1 (TCOF1) Antikörper

TCOF1 encodes a nucleolar protein with a LIS1 homology domain. Zusätzlich bieten wir Ihnen TCOF1 Proteine (4) und TCOF1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Ratte TCOF1 TCOF1 291571  
TCOF1 21453 O08784
TCOF1 6949 Q13428
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Top anti-TCOF1 Antikörper auf

Showing 10 out of 36 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from Jurkat/293/HeLa cells, using TCOF1 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TCOF1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Human Maus Unkonjugiert WB Western Blot analysis of TCOF1 expression in transfected 293T cell line by TCOF1 monoclonal antibody (M02), clone 8H3. Lane 1: TCOF1 transfected lysate(152.104 KDa). Lane 2: Non-transfected lysate. 0.1 mg Anmelden zum Anzeigen 12 bis 16 Tage
454,76 €
Human Kaninchen Unkonjugiert ChIP, IC, IF, IHC, WB Immunofluorescent analysis of TCOF1 staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of TCOF1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Anmelden zum Anzeigen 7 bis 8 Tage
464,29 €
Human Kaninchen Unkonjugiert IHC (p), ELISA, WB 50 μL Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of extracts from Jurkat/293/HeLa cells, using TCOF1 Antibody . The lane on the right is treated with the synthesized peptide. 50 μg Anmelden zum Anzeigen 8 bis 10 Tage
517,00 €
Xenopus laevis Maus Unkonjugiert IHC (fro), IF, WB   5 mL Anmelden zum Anzeigen 8 bis 10 Tage
264,00 €
Human Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 12 Days
261,90 €
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p)   0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
418,75 €
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB   100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Human Kaninchen Unkonjugiert IHC, ELISA, WB 100 μg Anmelden zum Anzeigen 15 bis 21 Tage
419,39 €

TCOF1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Mouse (Murine)

Human , , , ,
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Am meisten referenzierte anti-TCOF1 Antikörper

  1. Xenopus laevis Monoclonal TCOF1 Primary Antibody für IHC (fro), IF - ABIN126712 : Derenzini, Romagnoli, Mingazzini, Marinozzi: Interphasic nucleolar organizer region distribution as a diagnostic parameter to differentiate benign from malignant epithelial tumors of human intestine. in Virchows Archiv. B, Cell pathology including molecular pathology 1988 (PubMed)
    Zeige alle 3 Referenzen für ABIN126712

  2. Human Polyclonal TCOF1 Primary Antibody für IHC, ELISA - ABIN1533867 : So, Gonzales, Henning, Dixon, Dixon, Valdez: Another face of the Treacher Collins syndrome (TCOF1) gene: identification of additional exons. in Gene 2004 (PubMed)

Weitere Antikörper gegen TCOF1 Interaktionspartner

Mouse (Murine) Treacher Collins-Franceschetti Syndrome 1 (TCOF1) Interaktionspartner

  1. Role of Tcof1 in normal embryonic development, the correlation between genetic and environmental factors on the severity of craniofacial abnormalities, and the prospect for prenatal prevention of craniofacial anomalies. [review]

  2. Tcof1 acts as a modifier of Pax3 (zeige PAX3 Antikörper) during enteric nervous system development.

  3. identified Tcof1 as an important regulator of vagal neural crest cells (NCC (zeige SLC12A3 Antikörper)) development and enteric nervous system formation; Tcof1 loss-of-function results in a deficiency of vagal NCC (zeige SLC12A3 Antikörper) and their delayed colonization of the gut (zeige GUSB Antikörper) during early embryogenesis, which mimics the early stages of Hirschsprung's disease

  4. our research has therefore identified Treacle and as novel in vivo regulators of spindle fidelity, mitotic progression, and proliferation in the maintenance and localization of neural progenitor cells.

  5. Loss-of-function mutation in Tcof1 results in defects in middle ear postnatal development and conductive hearing loss.

  6. Results show that treacle is involved in ribosomal DNA gene transcription by interacting with upstream binding factor (UBF (zeige UBTF Antikörper)).

  7. Data show that Tcof1 and treacle synthesis play an important role in the proliferation of neuroblastoma (zeige ARHGEF16 Antikörper) cells.

  8. Analysis of RNA isolated from wild-type and Tcof1+/- heterozygous mice embryos from strains that exhibit a lethal phenotype showed significant reduction in 2'-O-methylation at nucleotide C463 of 18S rRNA

  9. A minimal promoter fragment from -253 to +43 bp (zeige EIF4EBP1 Antikörper) directs constitutive expression in both cell types, and dual regulation of Tcof1 appears to be through differential repression of this minimal promoter.

  10. It has been hypothesized that mutations in Tcof1 disrupt ribosome biogenesis to a degree that is insufficient to meet the proliferative needs of the neuroepithelium and neural crest cells.

Human Treacher Collins-Franceschetti Syndrome 1 (TCOF1) Interaktionspartner

  1. We report a clinical and extensive molecular study, including TCOF1, POLR1D (zeige POLR1D Antikörper), POLR1C (zeige POLR1C Antikörper), and EFTUD2 (zeige EFTUD2 Antikörper) genes, in a series of 146 patients with TCS.

  2. Autosomal recessive POLR1D (zeige POLR1D Antikörper) mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome.

  3. findings identify TCOF1 as a DDR (zeige DDR1 Antikörper) factor that could cooperate with ATM (zeige ATM Antikörper) and NBS1 (zeige NBN Antikörper) to suppress inappropriate rDNA transcription and maintain genomic integrity after DNA damage.

  4. we describe for the first time, two patients with MFD (zeige SCYL1 Antikörper) and ID and for whom a deletion encompassing TCOF1 and CAMK2A (zeige CAMK2A Antikörper) has been identified

  5. Mutations in TCOF1, POLR1C (zeige POLR1C Antikörper) and POLR1D (zeige POLR1D Antikörper) have all been implicated in causing TCS

  6. Treacle-mediated NBS1 (zeige NBN Antikörper) recruitment into the nucleoli regulates rRNA silencing in trans in the presence of distant chromosome breaks.

  7. TCOF1 genetic mutation can be a cause of Treacher Collins syndrome in Chinese patients.

  8. Presents the case of a male with Treacher Collins syndrome with a heterozygous de novo frameshift mutation within the TCOF1 gene (c.790_791delAG,p.Ser264GlnfsX7), as well as findings from three other individuals from two families with the same mutation.

  9. 6 of 12 patients diagnosed with hemifacial microsomia exhibited a novel frameshift mutation c. 4127 ins (zeige INS Antikörper) G in exon 24 in the TCOF1 gene.

  10. Gene rearrangements in TCOF1 are responsible for Treacher-Collins-Franceschetti syndrome.

TCOF1 Antigen-Profil

Protein Überblick

This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit TCOF1

  • Treacher Collins-Franceschetti syndrome 1 (Tcof1) Antikörper
  • Treacher Collins-Franceschetti syndrome 1 (TCOF1) Antikörper
  • Treacher Collins-Franceschetti syndrome 1 (LOC100226238) Antikörper
  • Treacher Collins-Franceschetti syndrome 1 (LOC100341764) Antikörper
  • Treacher Collins Franceschetti syndrome 1, homolog (Tcof1) Antikörper
  • AA408847 Antikörper
  • AW209012 Antikörper
  • MFD1 Antikörper
  • TCOF1 Antikörper
  • TCS1 Antikörper
  • treacle Antikörper

Bezeichner auf Proteinebene für TCOF1

Treacher Collins Franceschetti syndrome 1, homolog , Treacher Collins-Franceschetti syndrome 1 homolog , treacle protein , tcof1 gene exons 14-15-16a-16b , tcof1 gene exons 7-13 , treacle , Treacher Collins-Franceschetti syndrome 1 , treacle protein-like , treacher Collins syndrome protein homolog , Treacher Collins syndrome protein , nucleolar trafficking phosphoprotein

291571 Rattus norvegicus
403592 Canis lupus familiaris
416276 Gallus gallus
471696 Pan troglodytes
513591 Bos taurus
664735 Macaca mulatta
100060348 Equus caballus
100226238 Taeniopygia guttata
100341764 Oryctolagus cuniculus
100435631 Pongo abelii
100471510 Ailuropoda melanoleuca
100591432 Nomascus leucogenys
21453 Mus musculus
6949 Homo sapiens
Ausgewählte Anbieter für anti-TCOF1 (TCOF1) Antikörper
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