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Transmembrane Protein 66 Proteine (TMEM66)

Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. Zusätzlich bieten wir Ihnen TMEM66 Antikörper (26) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TMEM66 51669 Q96BY9
TMEM66 67887 Q8R3Q0
TMEM66 290796 Q6AYN2
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Showing 4 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.205,24 €
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Anmelden zum Anzeigen 15 bis 16 Tage
324,76 €
Details

TMEM66 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine)
,
Rat (Rattus)

Weitere Proteine zu Transmembrane Protein 66 (TMEM66) Interaktionspartnern

Human Transmembrane Protein 66 (TMEM66) Interaktionspartner

  1. SARAF modulates TRPC1 (zeige TRPC1 Proteine), but not TRPC6 (zeige TRPC6 Proteine), channel function in a STIM1 (zeige STIM1 Proteine)-independent manner

  2. SARAF overexpression attenuated store operated Ca2 (zeige CA2 Proteine)+ entry and the STIM1 (zeige STIM1 Proteine)-Orai1 interaction in cells endogenously expressing STIM1 (zeige STIM1 Proteine) and Orai1 while RNAi-mediated SARAF silencing induced opposite effects.

  3. SARAF is constitutively expressed in the plasma membrane and interacts with Orai1.

  4. Deletion of STIM1 (zeige STIM1 Proteine)(448-490) and, in particular, STIM1 (zeige STIM1 Proteine)(447-460) and STIM1 (zeige STIM1 Proteine)(475-490) markedly enhances interaction of SARAF with STIM1 (zeige STIM1 Proteine).

  5. Store-operated Ca2 (zeige CA2 Proteine)+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients.

  6. Study shows that SARAF is an endoplasmic reticulum resident protein, which responds to cytosolic Ca2 (zeige CA2 Proteine)+ elevation after ER Ca2 (zeige CA2 Proteine)+ refilling by promoting a slow inactivation process of STIM2 (zeige Stim2 Proteine)-dependent basal SOCE activity, as well as STIM1 (zeige STIM1 Proteine)-mediated SOCE activity.

TMEM66 Protein Überblick

Protein Überblick

Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (stim1 or stim2)- dependent SOCE activity (By similarity).

Genbezeichner und Symbole assoziert mit TMEM66

  • transmembrane protein 66 (TMEM66)
  • zgc:153286 (zgc:153286)
  • transmembrane protein 66 (tmem66)
  • transmembrane protein 66 (MCYG_05410)
  • transmembrane protein 66 (MGYG_06464)
  • transmembrane protein 66 (Tsp_10089)
  • Transmembrane protein 66 (tmm66)
  • transmembrane protein 66 (Tmem66)
  • 1810045K07Rik Protein
  • FOAP-7 Protein
  • SARAF Protein
  • tmem66 Protein
  • XTP3 Protein

Bezeichner auf Proteinebene für TMEM66

transmembrane protein 66 , SOCE-associated regulatory factor , store-operated calcium entry-associated regulatory factor , Transmembrane protein 66 , HBV X-transactivated gene 3 protein , HBV XAg-transactivated protein 3 , SARAF long isoform , SARAF short isoform , protein FOAP-7 , arrestin-E

GENE ID SPEZIES
422624 Gallus gallus
464092 Pan troglodytes
482878 Canis lupus familiaris
693452 Macaca mulatta
767649 Danio rerio
779232 Xenopus laevis
9228751 Arthroderma otae CBS 113480
10027179 Arthroderma gypseum CBS 118893
10905752 Trichinella spiralis
100154322 Sus scrofa
100174030 Pongo abelii
100195167 Salmo salar
51669 Homo sapiens
67887 Mus musculus
290796 Rattus norvegicus
515461 Bos taurus
Ausgewählte Anbieter für TMEM66 Proteine (TMEM66)
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