Translin (TSN) ELISA Kits

TSN encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Zusätzlich bieten wir Ihnen Translin Antikörper (55) und Translin Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
TSN 7247 Q15631
TSN 22099 Q62348
TSN 60381  
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Weitere ELISA Kits für Translin Interaktionspartner

Fruit Fly (Drosophila melanogaster) Translin (TSN) Interaktionspartner

  1. Study describes the identification of translin (trsn), a highly conserved RNA/DNA binding protein (zeige CNBP ELISA Kits), as essential for starvation-induced sleep suppression. Strikingly, trsn does not appear to regulate energy stores, free glucose levels, or feeding behavior suggesting the sleep phenotype of trsn mutant flies is not a consequence of general metabolic dysfunction or blunted response to starvation.

  2. These studies establish that Trax (zeige TSNAX ELISA Kits) adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.

  3. Drosophila translin exhibits a stable dimeric state that assembles into a suboctameric (tetramer/hexamer) form and fails (zeige AK3 ELISA Kits) to bind ssDNA and RNA targets

  4. A translin null mutant was generated and a trax (zeige TSNAX ELISA Kits) nonsense mutation was isolated. Translin is essential for stabilizing its interaction with trax (zeige TSNAX ELISA Kits).

  5. Drosophila translin may have roles in neuronal development and behavior analogous to that of mouse translin.

  6. Results suggest that the oligomeric status of translin critically influences the DNA binding properties of translin proteins.

  7. an RNAi regulator that we term C3PO (component 3 promoter of RISC (zeige SCPEP1 ELISA Kits)), a complex of Translin and Trax (zeige TSNAX ELISA Kits) was purified; C3PO is a Mg2 (zeige MCOLN1 ELISA Kits)+-dependent endoribonuclease that promotes RISC (zeige SCPEP1 ELISA Kits) activation by removing siRNA passenger strand cleavage products

Human Translin (TSN) Interaktionspartner

  1. Translin and Trax (zeige TSNAX ELISA Kits) control telomere-associated transcript levels in human cells in a telomere-specific fashion.

  2. results indicate that UPF1 (zeige UPF1 ELISA Kits) can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (zeige DCLRE1C ELISA Kits) (TSN)-mediated miRNA decay.

  3. These findings indicate that miRNA depletion in dicer (zeige DICER1 ELISA Kits) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.

  4. this study argues against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity.

  5. The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO.

  6. The data demonstrates that the configuration of translin and translin-RNA complexes in solution is a dimer of tetramers, which undergoes conformational transitions.

  7. Translin B3 motif, corresponding to TRAX (zeige TSNAX ELISA Kits) B3 residues, contributes towards its DNA binding activity.

  8. C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX (zeige TSNAX ELISA Kits) subunits which activates RISC (zeige SCPEP1 ELISA Kits) by degrading the Ago2 (zeige EIF2C2 ELISA Kits)-nicked passenger strand of siRNA.

  9. Sedimentation equilibrium studies using fluorescein-labeled single-stranded DNA support a model in which translin forms an annular structure of eight subunits, an oblate ellipsoid that binds single-stranded DNA at chromosomal breakpoints.

  10. study of reactivity of two -SH groups and stidu of proximity of Cys (zeige DNAJC5 ELISA Kits)-225 residues

Mouse (Murine) Translin (TSN) Interaktionspartner

  1. These findings indicate that miRNA depletion in dicer (zeige DICER1 ELISA Kits) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.

  2. These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF (zeige BDNF ELISA Kits) mRNA can be mediated by both translin-dependent and -independent mechanisms.

  3. trax (zeige TSNAX ELISA Kits) acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.

  4. TB-RBP is involved in the posttranscriptional regulation of Gapds (zeige GAPDHS ELISA Kits) gene expression during spermiogenesis.

  5. TB-RBP-null male mice were fertile and sired offspring but had abnormal seminiferous tubules and reduced sperm counts. Null female mice were subfertile, had reduced litter sizes; analysis of brain RNA from null mice revealed an altered gene expression

  6. TB-RBP-mouse ribonucleoprotein (zeige RBP31 ELISA Kits) complex transports a group of specific CREM (zeige CREM ELISA Kits)-regulated mRNAs in mammalian male postmeiotic germ cells.

  7. TB-RBP post-transcriptionally stabilizes TRAX (zeige TSNAX ELISA Kits) and both proteins are needed for normal cell proliferation

  8. subcellular locations of TB-RBP and TRAX (zeige TSNAX ELISA Kits) in male germ cells are modulated by the relative ratios of TRAX (zeige TSNAX ELISA Kits) and TB-RBP

  9. During a search for RNA-induced silencing complex (RISC (zeige SCPEP1 ELISA Kits)) proteins that directly interact with small interference RNA, the authors identify TB-RBP in NIH3T3 cell lysate and show that it possesses both single- and double-stranded RNase activities.

  10. These studies have, for the first time, identified both mRNAs and a non-coding RNA as TSN targets expressed during meiosis

Translin (TSN) Antigen-Profil

Beschreibung des Gens

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit Translin (TSN) ELISA Kits

  • translin L homeolog (tsn.L) Antikörper
  • translin (TSN) Antikörper
  • translin (trsn) Antikörper
  • haloacid dehalogenase (MMAH_RS03470) Antikörper
  • haloacid dehalogenase (TAGG_RS05275) Antikörper
  • Translin (Igag_0962) Antikörper
  • haloacid dehalogenase (MFER_RS03645) Antikörper
  • haloacid dehalogenase (DESMU_RS01315) Antikörper
  • translin (ARCVE_RS05265) Antikörper
  • haloacid dehalogenase (MZHIL_RS01310) Antikörper
  • translin (Tsn) Antikörper
  • 2610034C24Rik Antikörper
  • AU040286 Antikörper
  • BCLF-1 Antikörper
  • C3PO Antikörper
  • CG11761 Antikörper
  • Dmel\\CG11761 Antikörper
  • MGC52533 Antikörper
  • RCHF1 Antikörper
  • REHF-1 Antikörper
  • TB-RBP Antikörper
  • TBRBP Antikörper
  • TRSLN Antikörper
  • TSN Antikörper

Bezeichner auf Proteinebene für Translin (TSN) ELISA Kits

translin , CG11761-PA , testis-brain RNA binding protein , trsn-PA , Translin , component 3 of promoter of RISC , recombination hotspot associated factor , recombination hotspot-binding protein , testis brain-RNA binding protein , testis/brain RNA-binding protein , testis/brain-RNA-binding protein , translin protein

380118 Xenopus laevis
459586 Pan troglodytes
36110 Drosophila melanogaster
8982842 Methanohalophilus mahii DSM 5219
9166084 Thermosphaera aggregans DSM 11486
9716278 Ignisphaera aggregans DSM 17230
9962446 Methanothermus fervidus DSM 2088
10152942 Desulfurococcus mucosus DSM 2162
10394172 Archaeoglobus veneficus SNP6
10821850 Methanosalsum zhilinae DSM 4017
7247 Homo sapiens
22099 Mus musculus
60381 Rattus norvegicus
509943 Bos taurus
395955 Gallus gallus
100689410 Cricetulus griseus
100189807 Pongo abelii
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