anti-Translin (TSN) Antikörper

TSN encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Zusätzlich bieten wir Ihnen Translin Proteine (12) und Translin Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TSN 7247 Q15631
TSN 22099 Q62348
TSN 60381  
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Top anti-Translin Antikörper auf antikoerper-online.de

Showing 10 out of 55 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-TSN Antibody Titration: 1.0 ug/ml Positive Control: 293T Whole Cell There is BioGPS gene expression data showing that TSN is expressed in HEK293T 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of Translin staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Translin expression in MCF7 (A), HeLa (B), HepG2 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using TSN Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TSN Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB TSN Antibody (Center)  western blot analysis in HL-60,Jurkat,K562 cell line mouse spleen tissue lysates (35ug/lane).This demonstrates the TSN antibody detected the TSN protein (arrow). Fluorescent confocal image of Hela cell stained with TSN Antibody(Center).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with TSN primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃). Nuclei were counterstained with DAPI (blue) (10 µg/ml, 10 min).TSN immunoreactivity is localized to Nucleus and Cytoplasm significantly. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB   0.4 mL Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Details
Human Kaninchen Unkonjugiert EIA, IF, IHC (p), WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB <b>Immunohistochemistry </b>analysis of Translin Antibody in paraffin-embedded human brain tissue. <b>Western blot</b> analysis of Translin Antibody  in extracts from Jurkat cells. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
385,00 €
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Formalin-Fixed, Paraffin-Embedded Human Testis stained with TSN Western blot analysis of extracts from Jurkat cells using TSN Antibody . The lane on the right is treated with the synthesized peptide. 50 μL Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
Details

TSN Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , ,
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Mouse (Murine)


Rat (Rattus)


Weitere Antikörper gegen Translin Interaktionspartner

Fruit Fly (Drosophila melanogaster) Translin (TSN) Interaktionspartner

  1. Study describes the identification of translin (trsn), a highly conserved RNA/DNA binding protein (zeige CNBP Antikörper), as essential for starvation-induced sleep suppression. Strikingly, trsn does not appear to regulate energy stores, free glucose levels, or feeding behavior suggesting the sleep phenotype of trsn mutant flies is not a consequence of general metabolic dysfunction or blunted response to starvation.

  2. These studies establish that Trax (zeige TSNAX Antikörper) adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.

  3. Drosophila translin exhibits a stable dimeric state that assembles into a suboctameric (tetramer/hexamer) form and fails (zeige AK3 Antikörper) to bind ssDNA and RNA targets

  4. A translin null mutant was generated and a trax (zeige TSNAX Antikörper) nonsense mutation was isolated. Translin is essential for stabilizing its interaction with trax (zeige TSNAX Antikörper).

  5. Drosophila translin may have roles in neuronal development and behavior analogous to that of mouse translin.

  6. Results suggest that the oligomeric status of translin critically influences the DNA binding properties of translin proteins.

  7. an RNAi regulator that we term C3PO (component 3 promoter of RISC (zeige SCPEP1 Antikörper)), a complex of Translin and Trax (zeige TSNAX Antikörper) was purified; C3PO is a Mg2 (zeige MCOLN1 Antikörper)+-dependent endoribonuclease that promotes RISC (zeige SCPEP1 Antikörper) activation by removing siRNA passenger strand cleavage products

Human Translin (TSN) Interaktionspartner

  1. These findings indicate that miRNA depletion in dicer (zeige DICER1 Antikörper) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.

  2. this study argues against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity.

  3. The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO.

  4. The data demonstrates that the configuration of translin and translin-RNA complexes in solution is a dimer of tetramers, which undergoes conformational transitions.

  5. Translin B3 motif, corresponding to TRAX (zeige TSNAX Antikörper) B3 residues, contributes towards its DNA binding activity.

  6. C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX (zeige TSNAX Antikörper) subunits which activates RISC (zeige SCPEP1 Antikörper) by degrading the Ago2 (zeige EIF2C2 Antikörper)-nicked passenger strand of siRNA.

  7. Sedimentation equilibrium studies using fluorescein-labeled single-stranded DNA support a model in which translin forms an annular structure of eight subunits, an oblate ellipsoid that binds single-stranded DNA at chromosomal breakpoints.

  8. study of reactivity of two -SH groups and stidu of proximity of Cys (zeige DNAJC5 Antikörper)-225 residues

  9. At high enough concentrations, translin binds duplex DNA by selectively loading from the free ends, which apparently results in clamping of strands at the duplex ends.

  10. The core protein of HCV can interact with translin protein. This can partly explain the molecular mechanism for hepatocellular carcinoma and lymphoma caused by HCV

Mouse (Murine) Translin (TSN) Interaktionspartner

  1. These findings indicate that miRNA depletion in dicer (zeige DICER1 Antikörper) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.

  2. These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF (zeige BDNF Antikörper) mRNA can be mediated by both translin-dependent and -independent mechanisms.

  3. trax (zeige TSNAX Antikörper) acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.

  4. TB-RBP is involved in the posttranscriptional regulation of Gapds (zeige GAPDHS Antikörper) gene expression during spermiogenesis.

  5. TB-RBP-null male mice were fertile and sired offspring but had abnormal seminiferous tubules and reduced sperm counts. Null female mice were subfertile, had reduced litter sizes; analysis of brain RNA from null mice revealed an altered gene expression

  6. TB-RBP-mouse ribonucleoprotein complex transports a group of specific CREM (zeige CREM Antikörper)-regulated mRNAs in mammalian male postmeiotic germ cells.

  7. TB-RBP post-transcriptionally stabilizes TRAX (zeige TSNAX Antikörper) and both proteins are needed for normal cell proliferation

  8. subcellular locations of TB-RBP and TRAX (zeige TSNAX Antikörper) in male germ cells are modulated by the relative ratios of TRAX (zeige TSNAX Antikörper) and TB-RBP

  9. During a search for RNA-induced silencing complex (RISC (zeige SCPEP1 Antikörper)) proteins that directly interact with small interference RNA, the authors identify TB-RBP in NIH3T3 cell lysate and show that it possesses both single- and double-stranded RNase activities.

  10. These studies have, for the first time, identified both mRNAs and a non-coding RNA as TSN targets expressed during meiosis

Translin (TSN) Antigen-Profil

Protein Überblick

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit anti-Translin (TSN) Antikörper

  • translin (tsn) Antikörper
  • translin (TSN) Antikörper
  • translin (trsn) Antikörper
  • Translin (Mmah_0686) Antikörper
  • translin (Tagg_1053) Antikörper
  • Translin (Igag_0962) Antikörper
  • translin (Mfer_0716) Antikörper
  • translin (Desmu_0251) Antikörper
  • translin (Arcve_1059) Antikörper
  • translin (Mzhil_0248) Antikörper
  • translin (Tsn) Antikörper
  • 2610034C24Rik Antikörper
  • AU040286 Antikörper
  • BCLF-1 Antikörper
  • C3PO Antikörper
  • CG11761 Antikörper
  • Dmel\\CG11761 Antikörper
  • MGC52533 Antikörper
  • RCHF1 Antikörper
  • REHF-1 Antikörper
  • TB-RBP Antikörper
  • TBRBP Antikörper
  • TRSLN Antikörper
  • TSN Antikörper

Bezeichner auf Proteinebene für anti-Translin (TSN) Antikörper

translin , CG11761-PA , testis-brain RNA binding protein , trsn-PA , Translin , component 3 of promoter of RISC , recombination hotspot associated factor , recombination hotspot-binding protein , testis brain-RNA binding protein , testis/brain RNA-binding protein , testis/brain-RNA-binding protein , translin protein

GENE ID SPEZIES
380118 Xenopus laevis
459586 Pan troglodytes
36110 Drosophila melanogaster
8982842 Methanohalophilus mahii DSM 5219
9166084 Thermosphaera aggregans DSM 11486
9716278 Ignisphaera aggregans DSM 17230
9962446 Methanothermus fervidus DSM 2088
10152942 Desulfurococcus mucosus DSM 2162
10394172 Archaeoglobus veneficus SNP6
10821850 Methanosalsum zhilinae DSM 4017
7247 Homo sapiens
22099 Mus musculus
60381 Rattus norvegicus
509943 Bos taurus
395955 Gallus gallus
100689410 Cricetulus griseus
100189807 Pongo abelii
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