Transition Protein 1 (During Histone To Protamine Replacement) Proteine (TNP1)

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880\; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen TNP1 Antikörper (28) und TNP1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNP1 21958 P10856
TNP1 24839 P02317
TNP1 7141 P09430
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Showing 8 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
682,86 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
1.934,60 €
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Hefe Schaf His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
1.934,60 €
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
1.934,60 €
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
1.934,60 €
Details

TNP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)
,
Rat (Rattus)

Human ,
,

Weitere Proteine zu Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) Interaktionspartnern

Mouse (Murine) Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) Interaktionspartner

  1. The elevated levels of the remaining TP in Tnp-mutant mice appeared to be a consequence of the prolonged nucleus retention, rather than increased synthesis.

  2. Epididymal sperm from the Tnp1 null genotypes demonstrated a general decrease in normal morphology, motility, chromatin condensation, and degree of protamine 2 (zeige PRM2 Proteine) processing with decreasing levels of transition proteins in mutant sperm.

  3. JHDM2A (zeige KDM3A Proteine) directly binds to and controls the expression of transition nuclear protein 1 (zeige NUPR1 Proteine) (Tnp1) and protamine 1 (Prm1 (zeige PRM1 Proteine)) genes, the products of which are required for packaging and condensation of sperm chromatin

Human Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) Interaktionspartner

  1. Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 (zeige RRP8 Proteine) and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively.

  2. frequency of the haplotype GCG (zeige GCG Proteine) (H3) was increased in azoospermic men compared with fertile men. expression analysis of the TNP1 gene in obstructive azoospermic men showed that haplotypes of the TNP1 gene do not affect its expression level.

  3. a deletion of 15 nucleotides encompassing the recognition site for the cAMP response element transcription factor was found in the 5'-promoter region of the TNP1 gene in infertile men; this deletion reduces TNP1 expression and may cause infertility

  4. We found significantly lower levels of HILS1, TNP1, and TNP2 (zeige TNP2 Proteine) transcripts in spermatozoa from asthenozoospermic men compared to normozoospermic men.

  5. The TNP1 contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos.

  6. The presence of transition proteins (TP1 (zeige RPLP2 Proteine) and/or TP2 (zeige TERT Proteine)) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men.

Cow (Bovine) Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) Interaktionspartner

  1. We propose that SNPs on the TNP1 3'-UTR may help select semen quality trait in Chinese Holstein bulls in the dairy industry.

TNP1 Protein Überblick

Protein Überblick

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880\; PRM2, MIM 182890) (Luerssen et al., 1990

Genbezeichner und Symbole assoziert mit TNP1

  • transition protein 1 (during histone to protamine replacement) (TNP1)
  • transition protein 1 (during histone to protamine replacement) (LOC100349146)
  • spermatid nuclear transition protein 1-like (LOC100513764)
  • transition protein 1 (Tnp1)
  • Stp-1 Protein
  • TNP1 Protein
  • Tp-1 Protein
  • TP1 Protein

Bezeichner auf Proteinebene für TNP1

transition protein 1 (during histone to protamine replacement) , Spermatid nuclear transition protein 1 , spermatid nuclear transition protein 1 , STP-1 , TP-1 , testis-specific basic protein

GENE ID SPEZIES
696593 Macaca mulatta
100349146 Oryctolagus cuniculus
740418 Pan troglodytes
100630835 Equus caballus
100513764 Sus scrofa
21958 Mus musculus
24839 Rattus norvegicus
7141 Homo sapiens
100686780 Canis lupus familiaris
407743 Sus scrofa
281537 Bos taurus
101108026 Ovis aries
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