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The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Zusätzlich bieten wir Ihnen TRPM2 Antikörper (95) und TRPM2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
We conclude from these studies that inhibition of ROS (zeige ROS1 ELISA Kits) production, and the subsequent abrogation of TRPM2 (zeige CLU ELISA Kits)-mediated Ca(2 (zeige CA2 ELISA Kits)+) influx, is the primary mechanism underlying RE-1's inhibitory effect on LNs-induced inflammasome activation.
oxidative stress activated the TRPM2 (zeige CLU ELISA Kits)-CaMKII (zeige CAMK2G ELISA Kits) cascade to further induce intracellular ROS (zeige ROS1 ELISA Kits) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential
The work summarized here shows that TRPM2 (zeige CLU ELISA Kits) channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS (zeige ROS1 ELISA Kits)
Activation of TRPM2 (zeige CLU ELISA Kits) channels, however, caused intracellular release of not only Ca(2 (zeige CA2 ELISA Kits)+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2 (zeige CA2 ELISA Kits)+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.
neutrophils sense reactive oxygen species via the TRPM2 (zeige CLU ELISA Kits) channel to arrest migration at their target site.
The inhibitory function of oxidant sensing by TRPM2 (zeige CLU ELISA Kits) requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1 (zeige FPR1 ELISA Kits)) and subsequent FPR1 (zeige FPR1 ELISA Kits) internalization and signaling inhibition
findings demonstrate the important function of TRPM2 (zeige CLU ELISA Kits) in modulation of cell survival through mitochondrial ROS (zeige ROS1 ELISA Kits), and the potential of targeted inhibition of TRPM2 (zeige CLU ELISA Kits) as a therapeutic approach to reduce cellular bioenergetics, tumor growth, and enhance susceptibility to chemotherapeutic agents.
Study demonstrate that PRL is necessary for the survival of (retinal pigment epithelium) RPE under normal and advancing age conditions and, identified SIRT2 and TRPM2 as molecular targets for the antioxidant and antiapoptotic actions of PRL in the RPE.
TRPM2 (zeige CLU ELISA Kits) has a role in the DNA damage response of T cell leukemia cells in a BCL-2 (zeige BCL2 ELISA Kits) dependent manner
Data show that HEK293 cells expressing low levels of receptor potential melastatin 2 (TRPM2) chan (zeige TRPM3 ELISA Kits)nel wer (zeige CLU ELISA Kits)e more susceptible to silica nanoparticles (NPs) than those expressing high levels of TRPM2.
this study shows that TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection
Overexpression of TRPM2 channel prevented neutrophil transendothelial migration and vascular injury.
These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.
TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.
Lysophosphatidylcholine induces intracellular Ca(2 (zeige CA2 ELISA Kits)+) influx and increases phosphorylation of p38 MAPK (zeige MAPK14 ELISA Kits) via TRPM2, which in turn activates microglia.
The current study demonstrated that a physiological concentration of adrenaline attenuates insulin (zeige INS ELISA Kits) release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.
Trpm2 does not seem to play a major role in myeloid leukemogenesis. Additionally, loss of Trpm2 does not augment the cytotoxicity of standard AML (zeige RUNX1 ELISA Kits) chemotherapeutic agents.
TRPM2 channels contribute to visceral nociception in response to noxious stimuli under normal conditions and visceral hypersensitivity in pathological conditions.
Data show that macrophages from young mice showed lower transient receptor potential melastatin 2 (zeige TRPM3 ELISA Kits) (TRPM2) expression than those from senescent mice and had lower viability after silica nanoparticles (NPs (zeige NPS ELISA Kits)) exposure than those from senescent ones.
TRPM2 activation is likely to be mediated by ADP-ribose production via PARP (zeige PARP1 ELISA Kits) pathway
Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .
heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (zeige TRPC3 ELISA Kits) or TRPC7 protein induce enhanced receptor-activated Ca(2 (zeige CA2 ELISA Kits)+) influx that may lead to dysregulated cell growth in ADPKD
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
, estrogen-responsive element-associated gene 1 protein
, long transient receptor potential channel 2
, transient receptor potential cation channel subfamily M member 2
, transient receptor potential channel 7
, transient receptor potential melastatin family 2
, transient receptor potential cation channel, subfamily M, member 2
, transient receptor potential cation channel, subfamily C, member 7
, transient receptor potential cation channel, subfamily C, member 7-like
, short transient receptor potential channel 7-like
, transient receptor potential cation channel subfamily M member 2-like
, transient receptor protein 7
, transient receptor potential channel subfamily C member 7