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anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Antikörper

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Zusätzlich bieten wir Ihnen TRPM2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TRPM2 7226 O94759
TRPM2 28240  
TRPM2 294329  
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Top anti-TRPM2 Antikörper auf antikoerper-online.de

Showing 10 out of 81 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Maus Kaninchen Unkonjugiert ICC, IHC (fro), IF, IHC, WB Staining of rat hippocampus using ABIN259658. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
311,00 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IP, WB Western Blot: TRPM2 Antibody [ABIN153041] - Membrane Prep (50 ug) from Jurkat cells. Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-TRPM2 antibody, IHC(P) IHC(P): Rat Brain Tissue Anti-TRPM2 antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Mouse Brain Tissue Lysate Lane 3: Mouse Liver Tissue Lysate Lane 4: JURKAT Cell Lysate Lane 5: HELA Cell Lysate Lane 6: A549 Cell Lysate 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
298,57 €
Details
Human Kaninchen Unkonjugiert ICC, IHC (fro), IF, IP, IHC, WB Western Blot: TRPM2 Antibody  - Samples: Membrane Prep (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-TRPM2 antibody (lot was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. Western Blot: TRPM2 Antibody  - Samples: Jurkat Membrane Prep (50, 15, 5 ug). Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details
Maus Kaninchen DyLight 550 ICC, IF, IHC, IHC (fro), WB   0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
381,00 €
Details
Human Ziege Unkonjugiert IHC (p) Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
Details
Meerschweinchen Kaninchen Unkonjugiert IHC (p), WB Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Heart, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
801,43 €
Details
Maus Kaninchen Unkonjugiert ICC, IF, WB Detection of TRPM2 in mouse brain membrane lysates using ABIN259771. Immunocytochemistry/Immunofluorescence: TRPM2 Antibody [ABIN2597714] - TRPM2 antibody was tested in Neuro2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
291,00 €
Details
Human Ziege Unkonjugiert IHC (p) Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
Details

TRPM2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine) , , , ,
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Am meisten referenzierte anti-TRPM2 Antikörper

  1. Mouse (Murine) Polyclonal TRPM2 Primary Antibody für ICC, IHC (fro) - ABIN259658 : Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. in Neurotoxicology 2010 (PubMed)
    Zeige alle 8 Referenzen für ABIN259658

  2. Human Polyclonal TRPM2 Primary Antibody für ICC, IHC (fro) - ABIN153042 : Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Zeige alle 4 Referenzen für ABIN153042

  3. Human Polyclonal TRPM2 Primary Antibody für ICC, IF - ABIN153041 : Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. in Journal of medicinal chemistry 2013 (PubMed)
    Zeige alle 2 Referenzen für ABIN153041

  4. Cow (Bovine) Polyclonal TRPM2 Primary Antibody für IHC, WB - ABIN2781840 : Hecquet, Ahmmed, Vogel, Malik: Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability. in Circulation research 2008 (PubMed)

  5. Mouse (Murine) Polyclonal TRPM2 Primary Antibody für ICC, IF - ABIN4362934 : Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. in Scientific reports 2015 (PubMed)

Weitere Antikörper gegen TRPM2 Interaktionspartner

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Interaktionspartner

  1. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  2. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (zeige TRPC3 Antikörper) or TRPC7 protein induce enhanced receptor-activated Ca(2 (zeige CA2 Antikörper)+) influx that may lead to dysregulated cell growth in ADPKD

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Interaktionspartner

  1. neutrophils sense reactive oxygen species via the TRPM2 (zeige CLU Antikörper) channel to arrest migration at their target site.

  2. The inhibitory function of oxidant sensing by TRPM2 (zeige CLU Antikörper) requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1 (zeige FPR1 Antikörper)) and subsequent FPR1 (zeige FPR1 Antikörper) internalization and signaling inhibition

  3. findings demonstrate the important function of TRPM2 (zeige CLU Antikörper) in modulation of cell survival through mitochondrial ROS (zeige ROS1 Antikörper), and the potential of targeted inhibition of TRPM2 (zeige CLU Antikörper) as a therapeutic approach to reduce cellular bioenergetics, tumor growth, and enhance susceptibility to chemotherapeutic agents.

  4. Study demonstrate that PRL (zeige PRL Antikörper) is necessary for the survival of (retinal pigment epithelium) RPE (zeige RPE Antikörper) under normal and advancing age conditions and, identified SIRT2 (zeige SIRT2 Antikörper) and TRPM2 (zeige CLU Antikörper) as molecular targets for the antioxidant and antiapoptotic actions of PRL (zeige PRL Antikörper) in the RPE (zeige RPE Antikörper).

  5. TRPM2 (zeige CLU Antikörper) has a role in the DNA damage response of T cell leukemia cells in a BCL-2 (zeige BCL2 Antikörper) dependent manner

  6. Data show that HEK293 cells expressing low levels of receptor potential melastatin 2 (TRPM2) chan (zeige TRPM3 Antikörper)nel wer (zeige CLU Antikörper)e more susceptible to silica nanoparticles (NPs) than those expressing high levels of TRPM2.

  7. This is expected to provide a basis for inhibiting TRPM2 (zeige CLU Antikörper) for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.

  8. In a transgenic mouse model of Alzheimer's disease, TRPM2 (zeige CLU Antikörper) was involved in neuronal toxicity and memory impairment.

  9. These findings shed new light on the evolution of TRPM2 (zeige CLU Antikörper) and establish nvTRPM2 as a promising tool to decipher its complex gating mechanisms.

  10. we report here a novel effect promoted by TRPM2 (zeige CLU Antikörper), where it functions to minimize DNA damage and thus may have a role in the protection of genomic DNA in breast cancer cells.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Interaktionspartner

  1. Lysophosphatidylcholine induces intracellular Ca(2 (zeige CA2 Antikörper)+) influx and increases phosphorylation of p38 MAPK (zeige MAPK14 Antikörper) via TRPM2, which in turn activates microglia.

  2. The current study demonstrated that a physiological concentration of adrenaline attenuates insulin (zeige INS Antikörper) release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.

  3. Trpm2 does not seem to play a major role in myeloid leukemogenesis. Additionally, loss of Trpm2 does not augment the cytotoxicity of standard AML (zeige RUNX1 Antikörper) chemotherapeutic agents.

  4. TRPM2 channels contribute to visceral nociception in response to noxious stimuli under normal conditions and visceral hypersensitivity in pathological conditions.

  5. Data show that macrophages from young mice showed lower transient receptor potential melastatin 2 (zeige TRPM3 Antikörper) (TRPM2) expression than those from senescent mice and had lower viability after silica nanoparticles (NPs (zeige NPS Antikörper)) exposure than those from senescent ones.

  6. TRPM2 activation is likely to be mediated by ADP-ribose production via PARP (zeige PARP1 Antikörper) pathway

  7. mice in which TRPM2 had been genetically deleted showed a striking deficit in their sensation of non-noxious warm temperatures, consistent with the idea that TRPM2 initiates a 'warm' signal which drives cool-seeking behaviour

  8. findings provide compelling evidence that F. tularensis catalase (zeige CAT Antikörper) restricts reactive oxygen species to temper macrophage TRPM2-mediated Ca(2 (zeige CA2 Antikörper)+) signaling and limit host immune function.

  9. TRPM2 plays roles in a wide range of pathological pain models based on peripheral and central neuroinflammation, rather than physiological nociceptive pain.

  10. The findings provide evidence for a mechanism by which Abeta (zeige APP Antikörper) impairs neurovascular regulation and suggest that TRPM2 channels are a potential therapeutic target to counteract cerebrovascular dysfunction in Alzheimer's dementia.

TRPM2 Antigen-Profil

Protein Überblick

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Genbezeichner und Symbole assoziert mit TRPM2

  • transient receptor potential cation channel, subfamily M, member 2 (TRPM2) Antikörper
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2) Antikörper
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2) Antikörper
  • 9830168K16Rik Antikörper
  • C79133 Antikörper
  • EREG1 Antikörper
  • KNP3 Antikörper
  • LTRPC2 Antikörper
  • NUDT9H Antikörper
  • NUDT9L1 Antikörper
  • si:ch73-263b18.1 Antikörper
  • Trp7 Antikörper
  • TRPC7 Antikörper
  • TRPM2 Antikörper
  • Trpm2-predicted Antikörper
  • Trrp7 Antikörper

Bezeichner auf Proteinebene für TRPM2

transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , short transient receptor potential channel 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor potential channel subfamily C member 7 , LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor protein 7 , transient receptor potential melastatin family 2

GENE ID SPEZIES
424835 Gallus gallus
470101 Pan troglodytes
703611 Macaca mulatta
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100443123 Pongo abelii
100479298 Ailuropoda melanoleuca
100479364 Ailuropoda melanoleuca
100539776 Meleagris gallopavo
100556895 Anolis carolinensis
100271727 Sus scrofa
7226 Homo sapiens
28240 Mus musculus
294329 Rattus norvegicus
508029 Bos taurus
Ausgewählte Anbieter für anti-TRPM2 (TRPM2) Antikörper
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