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TRPC5 belongs to the transient receptor family. Zusätzlich bieten wir Ihnen Transient Receptor Potential Cation Channel, Subfamily C, Member 5 Antikörper (89) und Transient Receptor Potential Cation Channel, Subfamily C, Member 5 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (zeige NCS1 ELISA Kits) in mitochondrial function via its association with several mitochondrial proteins.
Data found that the pig adrenal medulla expressed predominantly TRPC1 (zeige TRPC1 ELISA Kits), TRPC5, and TRPC6 (zeige TRPC6 ELISA Kits) transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.
induces the epithelial-mesenchymal transition through the HIF-1alpha (zeige HIF1A ELISA Kits)-Twist signaling pathway to promote tumor metastasis in colon cancer
TrpC5 causes a robust rise in [Ca2 (zeige CA2 ELISA Kits)+]i, enhanced Wnt5a (zeige WNT5A ELISA Kits) expression and nuclear translocation of beta-catenin (zeige CTNNB1 ELISA Kits), leading to reduced differentiation and enhanced cancer cell stemness.
These findings suggest identification of an important experimental tool compound, which has much higher potency for inhibiting TRPC1 (zeige TRPC1 ELISA Kits)/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC1 (zeige TRPC1 ELISA Kits)/4/5 channel family.
that Arg-593, a residue located in the E4 loop near the TRPC5 extracellular Gd(3+) binding site, is critical for conferring the sensitivity to GPCR (zeige NMUR1 ELISA Kits)-Gq/11-PLC (zeige HSPG2 ELISA Kits)-dependent gating on TRPC5.
Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation.
circulating exosome-carrying TRPC5 might act as a noninvasive chemoresistance marker and might serve as an adjuvant to the current imaging examination-based chemoresistance.
The essential role of TrpC5 in GLUT1 (zeige SLC2A1 ELISA Kits) induction and chemoresistance in colorectal cancer.
TrpC5 plays an important role in VEGF-mediated tumor angiogenesis, suggesting its potential clinical value for anti-angiogenesis therapy
TRPC5 mRNA and protein levels were up-regulated in focal cortical dysplasia cortical lesions.
Suppressing TrpC5 expression decreased nuclear beta-catenin (zeige CTNNB1 ELISA Kits) accumulation, reduced the induction of ABCB1 (zeige ABCB1 ELISA Kits), and reversed 5-fluorouracil neoplastic resistance.
These results indicate the contribution of heteromultimeric channels from TRPC1 (zeige TRPC1 ELISA Kits), TRPC4 (zeige TRPC4 ELISA Kits), and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.
that Arg-593, a residue located in the E4 loop near the TRPC5 extracellular Gd(3+) binding site, is critical for conferring the sensitivity to GPCR (zeige GPBAR1 ELISA Kits)-Gq/11-PLC (zeige HSPG2 ELISA Kits)-dependent gating on TRPC5.
novel functions of TRPC5 in regulating vascular aging
TRPC5 contributes to depolarization of the plasma membrane in gonadotropes upon GnRH (zeige GNRH1 ELISA Kits) stimulation and increases the intracellular Ca2 (zeige CA2 ELISA Kits)+ concentration via its own Ca2 (zeige CA2 ELISA Kits)+ permeability and via the activation of voltage-gated Ca2 (zeige CA2 ELISA Kits)+ channels.
the antidepressant and anxiolytic-like effects of a newly identified TRPC4 (zeige TRPC4 ELISA Kits)/C5 inhibitor, M084.
Riluzole can activate TRPC5 heterologously expressed in HEK293 cells as well as those endogenously expressed in the U-87 glioblastoma cell line.
Loss or inhibition of TRPC5 abrogates podocyte cytoskeletal remodeling, prevents Rac1 activation, & stabilizes synaptopodin (zeige SYNPO ELISA Kits). Genetic deletion or pharmacologic inhibition of TRPC5 protected mice from albuminuria.
the S4-S5 linker is a critical constituent of TRPC4 (zeige TRPC4 ELISA Kits)/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain.
Is unaltered in TRPC5 KO mice, but is abolished in TRPC1 (zeige TRPC1 ELISA Kits) KO and TRPC1 (zeige TRPC1 ELISA Kits)/4 DKO mice.
Nitrix oxide can negatively modulate endogenous TRPC5-containing channels through an indirect mechanism.
analysis of a TRPC6 (zeige TRPC6 ELISA Kits)-TRPC5 channel cascade that restricts endothelial cell movement
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).
transient receptor potential cation channel, subfamily C, member 5
, transient receptor potential channel subfamily C member 5
, short transient receptor potential channel 5
, transient receptor potential channel 5
, transient receptor protein 5
, capacitative calcium entry channel 2
, trp-related protein 5
, vtransient receptor potential cation channel, subfamily C, member 5