Transient Receptor Potential Cation Channel, Subfamily C, Member 3 Proteine (TRPC3)

The protein encoded by TRPC3 is a membrane protein that can form a non-selective channel permeable to calcium and other cations. Zusätzlich bieten wir Ihnen TRPC3 Antikörper (82) und TRPC3 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TRPC3 7222 Q13507
TRPC3 22065  
Ratte TRPC3 TRPC3 60395  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
304,76 €
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TRPC3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,
,

Weitere Proteine zu Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) Interaktionspartnern

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) Interaktionspartner

  1. Data show clear inhibition of the photouncaging- induced Ca2+ signal by the TRPC3 channel inhibitor SKF 96365.

  2. The subsequent ER stress-induced apoptosis exhibit a strong requirement for constitutive Ca(2+) influx and that TRPC3 contributes to this process.

  3. Data show that mechanical stretching of transient receptor potential cation channel, subfamily C, member 3 (TRPC3) overexpressing fibroblasts induced the activation of nuclear factor-kappa B (NFkappaB).

  4. TRPC3 and TRPC6 (zeige TRPC6 Proteine) participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.

  5. the first in vivo evidence for a proatherogenic role of endothelial TRPC3.

  6. Imin channels are regulated by STIM2 (zeige Stim2 Proteine), TRPC3-containing INS (zeige INS Proteine) channels are induced by STIM1 (zeige STIM1 Proteine), and TRPC1 (zeige TRPC1 Proteine)-composed Imax channels are activated by both STIM1 (zeige STIM1 Proteine) and STIM2 (zeige Stim2 Proteine).

  7. CaSR (zeige CASR Proteine) activation mediates Ca2 (zeige CA2 Proteine)+ influx and cell proliferation via TRPC3 and TRPC6 (zeige TRPC6 Proteine) in human mesangial cells

  8. although gene deletion of TRPC3 or TRPC6 (zeige TRPC6 Proteine) alone did not protect against hypertrophy or dysfunction from pressure overload, combined deletion was protective, supporting the value of dual inhibition

  9. there is an absolute requirement for TRPC3-mediated diacylglycerol-dependent Ca(2 (zeige CA2 Proteine)+) entry to initiate and sustain the spiking response.

  10. Removal of a large hydrophobic residue (I667A or I667E) generated TRPC3 channels with approximately 60% constitutive activity, suggesting I667 as part of the dynamic structure occluding the permeation path.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) Interaktionspartner

  1. In the present study, we have explored the hypothesis that TRPC3 and TRPC6 (zeige TRPC6 Proteine) channels expressed in VSMCs may have a differential contribution to the regulation of vascular tone, which could be relevant for the changes in vascular reactivity associated with essential hypertension

  2. data suggested Acetylcholine could induce Airway Smooth Muscle Cell proliferation, and TRPC3 may be involved in ACh (zeige FGFR3 Proteine)-induced ASMC proliferation that occurs with airway remodeling.

  3. The results of this study demonstrated that TRPC3 channels unequivocally contribute to pilocarpine-induced SE and could be a novel molecular target for new anticonvulsive drugs.

  4. Inhibiting TRPC3 with continuous subcutaneous administration of Pyr3 decreased enhanced pause (Penh) of OVA-sensitized mouse. Meanwhile, both Pyr3 and lentiviral shRNA treatment of ASMCs in OVA-sensitized mouse significantly decreased their proliferation and migration

  5. TRPC3 channels are required for the response to glucose of mediobasal hypothalamic glucose-excited neurons and the central effect of glucose on insulin (zeige INS Proteine) secretion and food intake.

  6. These findings suggest that Trpc3 is a mediator of pathologic cardiac hypertrophy not only through mediating part of the Ca(2 (zeige CA2 Proteine)+) influx, but also through control of CaV1.2 (zeige CACNA1C Proteine) expressions.

  7. Data show that mechanical stretching of transient receptor potential cation channel, subfamily C, member 3 (TRPC3) overexpressing fibroblasts induced the activation of nuclear factor-kappa B (NFkappaB).

  8. TRPC3 and TRPC6 (zeige TRPC6 Proteine) participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.

  9. May activate TRPC3 channels to cause extracellular Ca(2 (zeige CA2 Proteine)+) influx.

  10. These findings provide the first mechanistic insights into the TRPC3- dependent mechanisms, by which activated calcium signaling is coupled to lipid metabolismand the regulation of Purkinje cell development in the Mwk cerebellum.

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily C, Member 3 (TRPC3) Interaktionspartner

  1. Demonstrate that Ca(2+) entry via endothelial TRPC3 contributes to nitric oxide release and have revealed that hypoxia-reoxygenation is associated with inhibition of TRPC3 activity.

  2. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  3. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 or TRPC7 (zeige TRPM2 Proteine) protein induce enhanced receptor-activated Ca(2 (zeige CA2 Proteine)+) influx that may lead to dysregulated cell growth in ADPKD

TRPC3 Protein Überblick

Protein Überblick

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit TRPC3

  • transient receptor potential cation channel, subfamily C, member 3 (TRPC3)
  • transient receptor potential cation channel, subfamily C, member 3 (Trpc3)
  • Mwk Protein
  • Trcp3 Protein
  • Trp3 Protein
  • Trpc3 Protein
  • TrpC3c Protein
  • Trrp3 Protein

Bezeichner auf Proteinebene für TRPC3

transient receptor potential cation channel, subfamily C, member 3 , short transient receptor potential channel 3-like , short transient receptor potential channel 3 , hTrp-3 , transient receptor protein 3 , TRP-3 , mTrp3 , receptor-activated cation channel TRP3 , trp-related protein 3 , ion channel protein , transient receptor potential cation channel subfamily C member 3 , oocyte transient receptor potential channel

GENE ID SPEZIES
100072204 Equus caballus
428766 Gallus gallus
471294 Pan troglodytes
100135636 Cavia porcellus
100454158 Pongo abelii
100483524 Ailuropoda melanoleuca
7222 Homo sapiens
22065 Mus musculus
60395 Rattus norvegicus
483844 Canis lupus familiaris
397210 Sus scrofa
286866 Bos taurus
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