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TRPC1 encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Zusätzlich bieten wir Ihnen Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Proteine (6) und Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal TRPC1 Primary Antibody für ELISA, WB - ABIN563261
Zhang, Wang, Pan, Xu, Zhang: Measuring Ca2+ influxes of TRPC1-dependent Ca2+ channels in HL-7702 cells with non-invasive micro-test technique. in World journal of gastroenterology : WJG 2009
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Rat (Rattus) Polyclonal TRPC1 Primary Antibody für IHC, WB - ABIN351117
Lockwich, Liu, Singh, Jadlowiec, Weiland, Ambudkar: Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. in The Journal of biological chemistry 2000
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This study provided direct evidence that increasing extracellular Ca(2 (zeige CA2 Antikörper)+) enhanced TNF-alpha (zeige TNF Antikörper)-induced VCAM-1 (zeige VCAM1 Antikörper) activation and monocytes adhesion. Moreover, we identified a novel TRPC1/ERK1/2 (zeige MAPK1/3 Antikörper)/NFkappaB (zeige NFKB1 Antikörper) signaling pathway mediating VCAM-1 (zeige VCAM1 Antikörper) activation and monocyte adhesion in this pathological process.
These observations suggest that mechanical stretch may induce an influx of Ca(2 (zeige CA2 Antikörper)+) and up-regulation of IL-13 (zeige IL13 Antikörper) and MMP-9 (zeige MMP9 Antikörper) expression in 16HBE cells via activation of TRPC1
STIM1L (zeige STIM1 Antikörper) and TRPC1/4 are working together in myotubes to ensure efficient store refilling and a proper differentiation program.
SARAF (zeige TMEM66 Antikörper) modulates TRPC1, but not TRPC6 (zeige TRPC6 Antikörper), channel function in a STIM1 (zeige STIM1 Antikörper)-independent manner
These findings suggest identification of an important experimental tool compound, which has much higher potency for inhibiting TRPC1/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC1/4/5 channel family.
changes in cell cycle regulating genes in TRPC1-silenced cells indicate possible cell cycle arrest along with compensatory up-regulation of ERBB3 (zeige ERBB3 Antikörper) growth factor receptor (zeige RYK Antikörper)-amongst others-to maintain hepatocellular carcinoma cell proliferation.
OC. Our results provide the basis for further investigations of the drug-resistance-related functions of TRPC1 in ovarian cancer and other forms of cancer.
TRPC1 mRNA and protein levels were increased in FCDIa, FCDIIa, and FCDIIb patients.
HIF-1alpha (zeige HIF1A Antikörper) knockdown attenuated hypoxia-induced BMP4 (zeige BMP4 Antikörper) expression and knockdown of either HIF-1alpha (zeige HIF1A Antikörper) or BMP4 (zeige BMP4 Antikörper) abolished hypoxia-induced TRPC expression and basal [Ca(2 (zeige CA2 Antikörper)+)]i.
In c-kit (zeige KIT Antikörper)+ cardiac progenitor cells, silencing TRPC1 significantly reduced the Ca2 (zeige CA2 Antikörper)+ signaling through store-operated Ca2 (zeige CA2 Antikörper)+ channels, decreased cell proliferation and migration, and reduced expression of cyclin D1 (zeige CCND1 Antikörper), cyclin E (zeige CCNE1 Antikörper), and/or p-Akt (zeige AKT1 Antikörper).
Endogenous as well as overexpressed xTRPV6 interacts with xTRPC1.
our results suggest that calcium influx through mechanosensitive TRPC1 channels on filopodia activates calpain to control growth cone turning during development.
This study suggested that BDNF (zeige BDNF Antikörper)-induced synaptic potentiation involves coordinated presynaptic and postsynaptic responses and identifies TRPC1 as a molecular mediator for postsynaptic Ca2 (zeige CA2 Antikörper)+ elevation required for BDNF (zeige BDNF Antikörper)-induced synaptic plasticity.
XTRPC1, a Xenopus homolog of mammalian TRPC1, is required for proper growth cone turning responses of Xenopus spinal neurons to netrin-1 (zeige NTN1 Antikörper), brain-derived neurotrophic factor (zeige BDNF Antikörper) and myelin-associated glycoprotein (zeige MAG Antikörper), but not to semaphorin 3A (zeige SEMA3A Antikörper).
downregulation of Xenopus TRP-1 (zeige TYRP1 Antikörper) (xTRPC1) expression with a specific morpholino oligonucleotide abolished the growth-cone turning and Ca2 (zeige CA2 Antikörper)+ elevation induced by a netrin-1 (zeige NTN1 Antikörper) gradient
TRPC1 regulated directly or indirectly the expression of multiple proteins, which may be crucial for the maintenance of memory ability.
we confirmed that the activation of OTX2 (zeige OTX2 Antikörper), a determinant of DA neuron development and the expression of which is induced by thyroid hormone (zeige PTH Antikörper), is dependent on TRPC1-mediated calcium signaling.
These results indicate the contribution of heteromultimeric channels from TRPC1, TRPC4 (zeige TRPC4 Antikörper), and TRPC5 (zeige TRPC5 Antikörper) subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.
Ca(2 (zeige CA2 Antikörper)+) entry serves critical cellular functions in virtually every cell type, and appropriate regulation of Ca(2 (zeige CA2 Antikörper)+) in neurons is essential for proper function.
Down-regulation of TRPC1 in weight-bearing soleus muscles resulted in reduced muscle mass and reduced myofibre cross-sectional area.
these data indicate for the first time a functional interaction between Orai1 (zeige TMEM132A Antikörper), TRPC1, and CaV1.2 (zeige CACNA1C Antikörper) channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2 (zeige CA2 Antikörper)+) entry due to co-activation of Orai1 (zeige TMEM132A Antikörper)- and TRPC1-dependent store-operated Ca(2 (zeige CA2 Antikörper)+) channels and L-type Ca(2 (zeige CA2 Antikörper)+) channels.
mechanosensitive TRPC1 channels in murine PSCs exposed to elevated ambient pressure
The results of this study showed that Loss of TRPC1 facilitated the gliotic response induced by increased intraocular pressure (IOP), suggesting that the channel might contribute to the glial mechanosusceptibility.
transient receptor potential channel 1 suppression of basal sphingosine kinase 1 (zeige SPHK1 Antikörper) activity enables endothelial cell-barrier destabilization by edemagenic agonists
Together the data suggests that Ca(2 (zeige CA2 Antikörper)+) entry via the TRPC1 channels is essential for the activation of CaCC (zeige CLCA1 Antikörper)
the link between HG-induced changes in TRPC1 expression, enhanced Ca(2 (zeige CA2 Antikörper)+) entry, and endothelial dysfunction require further study
These results provide the first in vivo evidence that TRPC1 is essential for angiogenesis in zebrafish.
Demonstrate a novel role of the NO-cGMP-PKG (zeige PRKG1 Antikörper) pathway in the inhibition of 11,12-EET-induced smooth muscle hyperpolarization and relaxation via PKG (zeige PRKG1 Antikörper)-mediated phosphorylation of TRPC1.
Data found that the pig adrenal medulla expressed predominantly TRPC1, TRPC5 (zeige TRPC5 Antikörper), and TRPC6 (zeige TRPC6 Antikörper) transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.
Heteromeric TRPV4 (zeige TRPV4 Antikörper)-TRPC1 channels mediate CaSR (zeige CASR Antikörper)-induced vasorelaxation through NO production but not IKCa channel activation in rabbit mesenteric arteries.
a novel activation mechanism for TRPC1 SOCs in VSMCs, in which store depletion induces formation of TRPC1-Galphaq-PLCbeta1 complexes that lead to PKC stimulation and channel gating.
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.
, short transient receptor potential channel 1
, transient receptor potential canonical 1
, transient receptor protein 1
, transient receptor potential protein
, trp-related protein 1
, transient receptor potential channel 1
, store-operated calcium channel
, transient receptor potential channel subfamily C member 1
, transient receptor potential cation channel, subfamily C, member 1
, transient receptor potential cation channel subfamily C member 1
, short transient receptor potential channel 1-like
, calcium influx channel TRPC1A
, putative calcium influx channel TRPC1A