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The protein encoded by TAGLN is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Zusätzlich bieten wir Ihnen Transgelin Antikörper (182) und Transgelin Kits (21) und viele weitere Produktgruppen zu diesem Protein an.
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During transition from the pluripotent stage towards the neural developmental stage, TAGLN is differentially expressed in bipolar patient derived cells compared to control derived cells.
Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix.
transgelin (TAGLN), a transforming growth factor beta (TGFbeta (zeige TGFB1 Proteine))-inducible gene, was identified as an upregulated gene during in vitro osteoblastic and adipocytic differentiation of human bone marrow-derived stromal (skeletal) stem cells
regulates vasculogenic mimicry in breast cancer cells by enhancing interleukin-8 (zeige IL8 Proteine) uptake
Serum concentrations of CK-18 fragments and transgelin-2 correlate with the severity of NAFLD, but not with obesity.
Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis
activated AKT (zeige AKT1 Proteine) and JNK (zeige MAPK8 Proteine) signaling pathways promote the overexpression of transgelin
Cofilin-1 (zeige CFL1 Proteine) and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma
Both tissue and salivary transgelin mRNA were closely correlated with various important clinicopathological parameters and were independent prognosis factors for oral squamous cell carcinoma.
SM22alpha is a phosphorylation-regulated (zeige PHAX Proteine) suppressor of IKK (zeige CHUK Proteine)-IkappaBalpha (zeige NFKBIA Proteine)-NF-kappaB (zeige NFKB1 Proteine) signaling cascades.
Targeted elimination of TGFbetaR2 in TAGLN(+) cells impairs midline closure and prevents the correct subsequent patterning of the musculature and skeletal components.
SM22alpha promotes ubiquitination and degradation of MKP3. SM22alpha facilitates AngII-induced contraction by maintenance of ERK1/2 signaling.
TRAF6 (zeige TRAF6 Proteine)-SM22alpha-G6PD (zeige G6PD Proteine) pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.
Absent/lower SM22 alpha levels favor an increase in parietal epithelial cell transition cells and PECs expressing a progenitor marker, and a lower epithelial mesenchymal transformation rate versus SM22alpha+/+mice, where SM22 levels are increased in PECs.
SM22alpha-regulated molecular pathways contribute to vascular pathology.
Histological analysis did not reveal calcium deposits in the aortic roots of SM22alpha-Rankl (zeige TNFSF11 Proteine) ( tg ) mice
Data show that formation of a Krupple-like factor KLF4 (zeige KLF4 Proteine), pELK-1, and histone de-acetylase 2 (HDAC2 (zeige HDAC2 Proteine)) multiprotein complex dependent on the SM22alpha G/C Repressor element.
Data suggest that SM22alpha expression in renal tissues might be a hallmark of kidney diseases.
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.
, putative transgelin
, 22 kDa actin-binding protein
, smooth muscle protein 22-alpha
, transgelin variant 2
, actin-associated protein p27
, smooth muscle 22 protein
, 25 kDa F-actin-binding protein