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This locus encodes the transforming growth factor (TGF)-beta type III receptor. Zusätzlich bieten wir Ihnen TGFBR3 Antikörper (106) und TGFBR3 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
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Inhibition of genes for betaglycan and FIBP (zeige FIBP ELISA Kits) in granulosa cells in vitro suggests that they inhibit estradiol production in regressing subordinate follicles.
describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells
TGF-beta (zeige TGFB1 ELISA Kits) type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset PE. Endoglin (zeige ENG ELISA Kits) was increased in both subtypes.
TGFBR3 and/or MGEA5 (zeige MGEA5 ELISA Kits) rearrangements are much more common in hybrid hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas.
opposing functions for the different GAG modifications on TbetaRIII suggesting that Wnt (zeige WNT2 ELISA Kits) interactions with the TbetaRIII heparan sulfate chains result in inhibition of Wnt (zeige WNT2 ELISA Kits) signaling, likely via Wnt (zeige WNT2 ELISA Kits) sequestration, whereas the chondroitin sulfate GAG chains on TbetaRIII promote Wnt3a (zeige WNT3A ELISA Kits) signaling.
Results suggest that high expression levels of alpha-inhibin and beta-glycan transcripts in secretory phase endometrium are associated with a lower chance of achieving pregnancy with in vitro fertilization.
Results show decreased TbetaRIII expression with hepatocellullar carcinoma (HCC (zeige FAM126A ELISA Kits)) progression leading to the activation of Smad2 (zeige SMAD2 ELISA Kits) and suggest that TbetaRIII acts as a suppressive factor in regulating the migration and invasion of HCC (zeige FAM126A ELISA Kits), by inhibiting Smad2 (zeige SMAD2 ELISA Kits) and Akt (zeige AKT1 ELISA Kits) pathways.
Study shows that TbetaRIII expression is significantly decreased in salivary glands adenoid cystic carcinoma (ACC) patients and defines TbetaRIII as a biomarker exerting antitumor action on ACC progression.
No correlation of loss of heterozygosity at the TGFBR3 locus with clinicopathological parameters suggests that allelic imbalance may be an early genetic event during neoplastic transformation of human endometrium.
Study shows that GDF10 (zeige GDF10 ELISA Kits) is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition.
rs1192415 of TGFBR3 is associated with primary open angle glaucoma.
BMP2 (zeige BMP2 ELISA Kits) also requires Src (zeige SRC ELISA Kits) for filamentous actin polymerization in Tgfbr3(-/-) epicardial cells.
Study identified a novel major binding site for TGF-beta (zeige TGFB1 ELISA Kits)-like growth factors in TGFR-3. Findings potentially provide novel experimental insight into the general function of zona pellucida domain-containing proteins.
Retinoic acid enhanced TbetaRIII expression and that this increase contributed to LF-stimulated IgA production.
Pro-fibrotic cardiac effect of miR (zeige MLXIP ELISA Kits)-328 was mediated by down-regulating TGFbR3 and up-regulating TGFb1 (zeige TGFB1 ELISA Kits).
These data demonstrate that TbetaRIII regulates BMP-mediated signaling and biological effects, primarily through the ligand sequestration effects of sTbetaRIII in normal and cancerous mammary epithelial cells.
Glucocorticoids recruit Tgfbr3 and Smad1 (zeige SMAD1 ELISA Kits) to shift transforming growth factor-beta signaling from the Tgfbr1 (zeige TGFBR1 ELISA Kits)/Smad2 (zeige SMAD2 ELISA Kits)/3 axis to the Acvrl1 (zeige ACVRL1 ELISA Kits)/Smad1 (zeige SMAD1 ELISA Kits) axis in lung fibroblasts.
work reveals a 'seed and soil' mechanism where TGF-beta2 (zeige TGFB2 ELISA Kits) and TGF-beta (zeige TGFB1 ELISA Kits)-RIII signalling through p38alpha (zeige MAPK14 ELISA Kits)/beta regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis
TGFBR3 mediated suppression of cancer progression includes effects on the tumor immune microenvironment.
Loss of Tgfbr3 compromises the functions of TGFbeta2 in the differentiating fetal testis.
This study provides evidence that the expressions of inhibin alpha subunit (zeige INHA ELISA Kits) and betaglycan are inferior in cystic follicles, and this may be caused by the decrease in FSH (zeige BRD2 ELISA Kits) in the presence of a cystic follicle.
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
transforming growth factor, beta receptor III
, transforming growth factor, beta receptor III (betaglycan, 300kDa)
, transforming growth factor beta receptor type 3-like
, TGF-beta receptor type 3
, TGF-beta receptor type III
, betaglycan proteoglycan
, transforming growth factor beta receptor type 3
, transforming growth factor, beta receptor 3
, TGF-beta type III receptor
, transforming growth factor beta receptor III
, transforming growth factor-beta type III receptor