Transcription Factor 12 Proteine (TCF12)

The protein encoded by TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. Zusätzlich bieten wir Ihnen TCF12 Antikörper (92) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TCF12 6938 Q99081
TCF12 21406 Q61286
TCF12 25720 P51514
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Showing 7 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
218,90 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Primaten His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.248,89 €
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Hefe Mesocricetus auratus His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.069,52 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.867,46 €
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TCF12 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Transcription Factor 12 (TCF12) Interaktionspartnern

Human Transcription Factor 12 (TCF12) Interaktionspartner

  1. Heb expression is regulated by Med19 (zeige MED19 Proteine) in breast cancer cells.

  2. enforced expression of transcription factor 12 suppressed cell proliferation, migration, and invasion in vitro and inhibited tumor growth in vivo. In conclusion, transcription factor 12 protein may be a novel molecule which plays a critical role in prostate cancer progression and patients' prognosis, suggesting it might be a promising therapeutic target for prostate cancer therapy

  3. HEB may be involved in GBM cell proliferation, as HEB silencing reduced proliferation in cells cultured as monolayers or neurospheres. Furthermore, the results suggested a potential role for HEB in the maintenance of GBM stem cells, as HEB silencing affected the differentiation capacity of cells.

  4. Two novel translocations leading to the inactivation of RUNX1 (zeige RUNX1 Proteine) and its partners SIN3A (zeige SIN3A Proteine) and TCF12 in myeloid leukemia (zeige BCL11A Proteine).

  5. Studies suggest that transcription factor 12 (TCF12) should be included in level 2 genetic testing.

  6. show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumour type

  7. several familial cases of coronal synostosis associated with mutations in TCF12

  8. In t(8;21) leukemia cells, the two E proteins, HEB and E2A (zeige TCF3 Proteine), function as components of the stable AML1 (zeige RUNX1 Proteine)-ETO (zeige RUNX1T1 Proteine)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.

  9. haploinsufficiency of TCF12 causes coronal synostosis in humans and that severe bilateral coronal synostosis occ (zeige TWIST1 Proteine)urs in mice with 50% of the wild-type dosage of both the T (zeige TWIST1 Proteine)cf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1.

  10. the CD91 (zeige LRP1 Proteine)/IKK (zeige CHUK Proteine)/NF-kappaB (zeige NFKB1 Proteine) signaling cascade is involved in secreted HSP90alpha (zeige HSP90AA2 Proteine)-induced TCF12 expression, leading to E-cadherin (zeige CDH1 Proteine) down-regulation and enhanced CRC (zeige CALR Proteine) cell migration/invasion

Mouse (Murine) Transcription Factor 12 (TCF12) Interaktionspartner

  1. we identified transcription factor TCF12 as a new target of miR (zeige MLXIP Proteine)-211 in oral squamous cell carcinoma

  2. HEB is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells

  3. severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 (zeige TWIST1 Proteine) genes highlights the key role of TCF12 acting with TWIST1 (zeige TWIST1 Proteine) in the normal development of the coronal sutures

  4. Deficiency in the E proteins, E2A (zeige TCF3 Proteine) and HEB, led to increased frequency of terminally differentiated effector KLRG1 (zeige KLRG1 Proteine)(hi) CD8 (zeige CD8A Proteine)(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.

  5. Deletion of HEB and E2A (zeige TCF3 Proteine) in DP thymocytes specifically blocked the development of CD4 (zeige CD4 Proteine)(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 (zeige ID3 Proteine) allowed CD4 (zeige CD4 Proteine)(+) T cell development but blocked CD8 (zeige CD8A Proteine)(+) lineage development.

  6. the earliest event in B-cell specification involves the induction of FOXO1 (zeige FOXO1 Proteine) expression and requires the combined activities of E2A (zeige TCF3 Proteine) and HEB

  7. These results showed a new set of interactions between HEB, Notch1 (zeige NOTCH1 Proteine), and GATA3 (zeige GATA3 Proteine) that regulate the T-cell fate choice in developing thymocytes.

  8. Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt.

  9. HEB is a specific and essential factor in T-cell development and in the generation of the iNKT cell lineage.

  10. the dosage of HEB determines pT alpha (zeige PTCRA Proteine) gene expression in immature T cells

TCF12 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Genbezeichner und Symbole assoziert mit TCF12

  • transcription factor 12 (TCF12)
  • transcription factor 12 (LOC100339415)
  • transcription factor 12 (tcf12)
  • transcription factor 12 (Tcf12)
  • transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) (tcf12)
  • A130037E08Rik Protein
  • ALF1 Protein
  • bHLHb20 Protein
  • CRS3 Protein
  • HEB Protein
  • HEBAlt Protein
  • HsT17266 Protein
  • HTF-4 Protein
  • HTF4 Protein
  • ME1 Protein
  • REB Protein
  • SCBPA Protein
  • TCF12 Protein
  • wu:fb74g05 Protein
  • wu:fc43e06 Protein
  • zgc:85956 Protein
  • zgc:110341 Protein

Bezeichner auf Proteinebene für TCF12

transcription factor 12 , transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) , DNA-binding protein HTF4 , E-box-binding protein , TCF-12 , class B basic helix-loop-helix protein 20 , helix-loop-helix transcription factor 4 , transcription factor HTF-4 , class A helix-loop-helix transcription factor ME1 , SCBP alpha , SCBP-alpha , salivary-specific cAMP response element-binding protein alpha , TF12 , basic helix-loop-helix protein , class A helix-loop-helix transcription factor GE1 , XE1.1

GENE ID SPEZIES
453466 Pan troglodytes
100339415 Oryctolagus cuniculus
100460448 Pongo abelii
100553875 Anolis carolinensis
100603993 Nomascus leucogenys
6938 Homo sapiens
509039 Bos taurus
21406 Mus musculus
25720 Rattus norvegicus
407985 Danio rerio
396334 Gallus gallus
100684199 Canis lupus familiaris
399451 Xenopus laevis
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