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Transcription Factor 12 (TCF12) ELISA Kits

The protein encoded by TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. Zusätzlich bieten wir Ihnen TCF12 Antikörper (90) und TCF12 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human TCF12 TCF12 6938 Q99081
Anti-Maus TCF12 TCF12 21406 Q61286
Anti-Ratte TCF12 TCF12 25720 P51514
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Weitere ELISA Kits für TCF12 Interaktionspartner

Human Transcription Factor 12 (TCF12) Interaktionspartner

  1. HEB may be involved in GBM cell proliferation, as HEB silencing reduced proliferation in cells cultured as monolayers or neurospheres. Furthermore, the results suggested a potential role for HEB in the maintenance of GBM stem cells, as HEB silencing affected the differentiation capacity of cells.

  2. Two novel translocations leading to the inactivation of RUNX1 (zeige RUNX1 ELISA Kits) and its partners SIN3A and TCF12 in myeloid leukemia (zeige BCL11A ELISA Kits).

  3. Studies suggest that transcription factor 12 (TCF12) should be included in level 2 genetic testing.

  4. show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumour type

  5. several familial cases of coronal synostosis associated with mutations in TCF12

  6. In t(8;21) leukemia cells, the two E proteins, HEB and E2A (zeige TCF3 ELISA Kits), function as components of the stable AML1 (zeige RUNX1 ELISA Kits)-ETO (zeige RUNX1T1 ELISA Kits)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.

  7. haploinsufficiency of TCF12 causes coronal synostosis in humans and that severe bilateral coronal synostosis occ (zeige TWIST1 ELISA Kits)urs in mice with 50% of the wild-type dosage of both the T (zeige TWIST1 ELISA Kits)cf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1.

  8. the CD91 (zeige LRP1 ELISA Kits)/IKK (zeige CHUK ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits) signaling cascade is involved in secreted HSP90alpha-induced TCF12 expression, leading to E-cadherin (zeige CDH1 ELISA Kits) down-regulation and enhanced CRC (zeige CALR ELISA Kits) cell migration/invasion

  9. TCF12 functioned as a transcriptional repressor of E-cadherin (zeige CDH1 ELISA Kits) and its overexpression was significantly correlated with the occurrence of CRC (zeige CALR ELISA Kits) metastasis.

  10. HEB and E2A (zeige TCF3 ELISA Kits)-bind the SCA motif at regions overlapping SMAD2 (zeige SMAD2 ELISA Kits)/3 and FOXH1 (zeige FOXH1 ELISA Kits)

Mouse (Murine) Transcription Factor 12 (TCF12) Interaktionspartner

  1. HEB (zeige FREM1 ELISA Kits) is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells

  2. severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 (zeige TWIST1 ELISA Kits) genes highlights the key role of TCF12 acting with TWIST1 (zeige TWIST1 ELISA Kits) in the normal development of the coronal sutures

  3. Deficiency in the E proteins, E2A (zeige TCF3 ELISA Kits) and HEB (zeige FREM1 ELISA Kits), led to increased frequency of terminally differentiated effector KLRG1 (zeige KLRG1 ELISA Kits)(hi) CD8 (zeige CD8A ELISA Kits)(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.

  4. Deletion of HEB (zeige FREM1 ELISA Kits) and E2A (zeige TCF3 ELISA Kits) in DP thymocytes specifically blocked the development of CD4 (zeige CD4 ELISA Kits)(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 (zeige ID3 ELISA Kits) allowed CD4 (zeige CD4 ELISA Kits)(+) T cell development but blocked CD8 (zeige CD8A ELISA Kits)(+) lineage development.

  5. the earliest event in B-cell specification involves the induction of FOXO1 (zeige FOXO1 ELISA Kits) expression and requires the combined activities of E2A (zeige TCF3 ELISA Kits) and HEB (zeige FREM1 ELISA Kits)

  6. These results showed a new set of interactions between HEB (zeige FREM1 ELISA Kits), Notch1 (zeige NOTCH1 ELISA Kits), and GATA3 (zeige GATA3 ELISA Kits) that regulate the T-cell fate choice in developing thymocytes.

  7. Developmental progression of fetal HEB (zeige FREM1 ELISA Kits)(-/-) precursors to the pre-T-cell stage is restored by HEBAlt.

  8. HEB (zeige FREM1 ELISA Kits) is a specific and essential factor in T-cell development and in the generation of the iNKT cell lineage.

  9. the dosage of HEB (zeige FREM1 ELISA Kits) determines pT alpha (zeige PTCRA ELISA Kits) gene expression in immature T cells

  10. the Tcf12 gene may be involved in the control of proliferating neural stem cells and progenitor cells

TCF12 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Genbezeichner und Symbole assoziert mit TCF12

  • transcription factor 12 (TCF12) Antikörper
  • transcription factor 12 (LOC100339415) Antikörper
  • transcription factor 12 (tcf12) Antikörper
  • transcription factor 12 (Tcf12) Antikörper
  • transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) (tcf12) Antikörper
  • A130037E08Rik Antikörper
  • ALF1 Antikörper
  • bHLHb20 Antikörper
  • CRS3 Antikörper
  • HEB Antikörper
  • HEBAlt Antikörper
  • HsT17266 Antikörper
  • HTF-4 Antikörper
  • HTF4 Antikörper
  • ME1 Antikörper
  • REB Antikörper
  • SCBPA Antikörper
  • TCF12 Antikörper
  • wu:fb74g05 Antikörper
  • wu:fc43e06 Antikörper
  • zgc:85956 Antikörper
  • zgc:110341 Antikörper

Bezeichner auf Proteinebene für TCF12

transcription factor 12 , transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) , DNA-binding protein HTF4 , E-box-binding protein , TCF-12 , class B basic helix-loop-helix protein 20 , helix-loop-helix transcription factor 4 , transcription factor HTF-4 , class A helix-loop-helix transcription factor ME1 , SCBP alpha , SCBP-alpha , salivary-specific cAMP response element-binding protein alpha , TF12 , basic helix-loop-helix protein , class A helix-loop-helix transcription factor GE1 , XE1.1

GENE ID SPEZIES
453466 Pan troglodytes
100339415 Oryctolagus cuniculus
100460448 Pongo abelii
100553875 Anolis carolinensis
100603993 Nomascus leucogenys
6938 Homo sapiens
509039 Bos taurus
21406 Mus musculus
25720 Rattus norvegicus
407985 Danio rerio
396334 Gallus gallus
100684199 Canis lupus familiaris
399451 Xenopus laevis
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