Transcription Elongation Factor SPT5 (SUPT5H) ELISA Kits

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. Zusätzlich bieten wir Ihnen Transcription Elongation Factor SPT5 Antikörper (52) und Transcription Elongation Factor SPT5 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
SUPT5H 6829 O00267
SUPT5H 20924 O55201
Anti-Ratte SUPT5H SUPT5H 308472  
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Weitere ELISA Kits für Transcription Elongation Factor SPT5 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Transcription Elongation Factor SPT5 (SUPT5H) Interaktionspartner

  1. Spt5 interacts both physically and genetically with the Polycomb (zeige CBX2 ELISA Kits) Group (PcG) protein Pleiohomeotic (Pho)

  2. We show that SPT5 interacts directly with MSL1 in vitro and is required downstream of MSL complex recruitment, providing the first mechanistic data corroborating the elongation model of dosage compensation.

  3. Spt5 acts both positively and negatively on transcription in vivo during heat shock induction.

Arabidopsis thaliana Transcription Elongation Factor SPT5 (SUPT5H) Interaktionspartner

  1. SPT5-like protein emerged in plants as a facultative RNA polymerase elongation factor (zeige TSFM ELISA Kits).[SPT5]

Mouse (Murine) Transcription Elongation Factor SPT5 (SUPT5H) Interaktionspartner

  1. Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.

  2. our findings indicate that Spt4 (zeige SUPT4H1 ELISA Kits) and Spt5 have essential functions in the DNA repair phase of immunoglobulin class switch recombination.

  3. Study reports that Spt5, a factor normally associated with stalled or paused Pol II, is required for class switch recombination.

Zebrafish Transcription Elongation Factor SPT5 (SUPT5H) Interaktionspartner

  1. the positive function of Foggy/Spt5 is required for gata1 (zeige GATA1 ELISA Kits) expression during zebrafish embryonic hematopoiesis.

  2. RNA polymerase II elongation repression is critically dependent on the C-terminus of Spt5

  3. The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo.

  4. spt 5-dependent transcript elongation is required cell-autonomously for a complex cell migration

  5. Spt5 as a dual regulator of transcription elongation in vivo; a small but diverse set of target genes critically dependent on Spt5 during development.

Human Transcription Elongation Factor SPT5 (SUPT5H) Interaktionspartner

  1. The mobile C-terminal region of DSIF is located near exiting RNA, where it can recruit factors for RNA processing.

  2. OGA (zeige MGEA5 ELISA Kits) is physically associated with the known RNA polymerase II (pol II) pausing/elongation factors SPT5 and TRIM28-KAP1-TIF1beta (zeige TRIM28 ELISA Kits), and a purified OGA (zeige MGEA5 ELISA Kits)-SPT5-TIF1beta (zeige TRIM28 ELISA Kits) complex has elongation properties.

  3. A transcription-independent effect of tumor necrosis factor alpha (zeige TNF ELISA Kits) on RNA splicing, mediated by Spt5.

  4. SPT5 contributes to the up-regulation of hTERT expression and colonic tumor development.

  5. Data indicate that the Plus3 domain of the Rtf1 (zeige RTF1 ELISA Kits) subunit mediates Paf1C recruitment to genes by binding a repeating domain within the phosphorylated elongation factor (zeige TSFM ELISA Kits) Spt5.

  6. DSIF Is Selectively Required for mRNA Splicing and Export of NF-kappaB (zeige NFKB1 ELISA Kits) Target Genes.

  7. RNA polymerase II elongation repression is critically dependent on the C-terminus of Spt5

  8. crystal structure of hSpt4 (zeige SUPT4H1 ELISA Kits) in complex with the dimerization region of hSpt5

  9. phosphorylated by P-TEFb (zeige CCNT1 ELISA Kits) kinase during HIV-1 transcription in Tat (zeige TAT ELISA Kits)/TAR (zeige RBM8A ELISA Kits) dependent manner

  10. hSpt5 function in transcription regulation and mRNA capping is essential for a subset of cellular and viral genes and may not be required for global gene expression.

Transcription Elongation Factor SPT5 (SUPT5H) Antigen-Profil

Beschreibung des Gens

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

Genbezeichner und Symbole assoziert mit SUPT5H

  • SPT5 homolog, DSIF elongation factor subunit (SUPT5H) Antikörper
  • suppressor of Ty 5 (Supt5) Antikörper
  • transcription elongation factor SPT5 (LOC413814) Antikörper
  • Transcription elongation factor Spt5 (AT2G34210) Antikörper
  • transcription elongation factor Spt5 (spt5) Antikörper
  • transcription elongation factor spt5 (MGYG_08422) Antikörper
  • transcription elongation factor spt5 (TERG_05483) Antikörper
  • hypothetical protein (PGTG_18458) Antikörper
  • SPT5 homolog, DSIF elongation factor subunit (supt5h) Antikörper
  • SPT5 homolog, DSIF elongation factor subunit (Supt5h) Antikörper
  • SPT5 homolog, DSIF elongation factor subunit S homeolog (supt5h.S) Antikörper
  • CG7626 gene product from transcript CG7626-RA (Spt5) Antikörper
  • Transcription elongation factor SPT5 (spt-5) Antikörper
  • transcription elongation factor (SPT5) Antikörper
  • AL033283 Antikörper
  • AL033321 Antikörper
  • AU019549 Antikörper
  • CaO19.1453 Antikörper
  • CG7626 Antikörper
  • dDSIF Antikörper
  • Dmel\\CG7626 Antikörper
  • DSIF Antikörper
  • dSpt5 Antikörper
  • etID10129.15 Antikörper
  • etID37101.15 Antikörper
  • F13P17.5 Antikörper
  • F13P17_5 Antikörper
  • fb37g01 Antikörper
  • fb95e05 Antikörper
  • fog Antikörper
  • foggy Antikörper
  • spt5 Antikörper
  • spt5h Antikörper
  • Supt5h Antikörper
  • tat-ct1 Antikörper
  • wu:fb37g01 Antikörper
  • wu:fb95e05 Antikörper
  • wu:fc10f02 Antikörper

Bezeichner auf Proteinebene für SUPT5H

DRB sensitivity-inducing factor 160 kDa subunit , DRB sensitivity-inducing factor large subunit , DSIF large subunit , DSIF p160 , Tat-cotransactivator 1 protein , hSPT5 , transcription elongation factor SPT5 , suppressor of Ty 5 homolog , transcription elongation factor Spt5 , transcription elongation factor spt5 , protein foggy , transcription elongation regulator foggy , CG7626-PA , Spt5-PA , Chromatin elongation factor SPT5

GENE ID SPEZIES
6829 Homo sapiens
20924 Mus musculus
413814 Apis mellifera
817982 Arabidopsis thaliana
2541916 Schizosaccharomyces pombe 972h-
10024747 Arthroderma gypseum CBS 118893
10372474 Trichophyton rubrum CBS 118892
10537737 Puccinia graminis f. sp. tritici CRL 75-36-700-3
64275 Danio rerio
308472 Rattus norvegicus
426493 Gallus gallus
476462 Canis lupus familiaris
733281 Xenopus laevis
519808 Bos taurus
53442 Drosophila melanogaster
178143 Caenorhabditis elegans
100713914 Cavia porcellus
3635847 Candida albicans SC5314
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