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Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. Zusätzlich bieten wir Ihnen Transaldolase 1 Antikörper (75) und Transaldolase 1 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.
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Human TALDO1 Protein expressed in Escherichia coli (E. coli) - ABIN667176
Valayannopoulos, Verhoeven, Mention, Salomons, Sommelet, Gonzales, Touati, de Lonlay, Jakobs, Saudubray: Transaldolase deficiency: a new cause of hydrops fetalis and neonatal multi-organ disease. in The Journal of pediatrics 2006
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Human TALDO1 Protein expressed in Escherichia coli (E. coli) - ABIN1047748
Banki, Halladay, Perl: Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence. in The Journal of biological chemistry 1994
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These data reveal an essential role of transaldolase in sperm-cell mitochondrial function and, thus, male fertility.
Reduced beta-catenin (zeige CTNNB1 Proteine) phosphorylation and enhanced c-Jun (zeige JUN Proteine) expression in Taldo1-/- livers reflected adaptation to oxidative stress
The above findings support the premise that biallelic mutations in TALDO1 are responsible for transaldolase deficiency and confirm the broad phenotypic variability of this condition, even with the same genotype.
This study expands the clinical definition of transaldolase deficiency, and adds to its allelic heterogeneity.
Data suggest that exchange reactions during gluconeogenesis catalyzed by transaldolase and triose-phosphate isomerase (zeige TPI1 Proteine) do not differ between subjects with type 2 diabetes and control subjects under fasting or hyperglycemic conditions.
renal phenotype of patients with transaldolase deficiency
these data provide strong experimental evidence that transaldolase exchange occurs in humans, resulting in an overestimate of gluconeogenesis
granzyme B-cleaved transaldolase-specific T cell-mediated cytotoxicity may contribute to the progressive destruction of oligodendrocytes in patients with multiple sclerosis
transaldolase is regulated by ZNF143 (zeige ZNF143 Proteine) in a tissue-specific manner
Mutation in the TALDO1 gene was found in patients with hydrops fetalis and neonatal multi-organ disease.
Transaldolase-deficient patients had significantly increased urinary heptoses, revealing novel urinary biomarkers for identification of the deficiency.
The present study identified the TAL deficiency as a modulator of mitochondrial homoeostasis, Ca(2 (zeige CA2 Proteine)+) fluxing and apoptosis.
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
, EPS8-like 2
, transaldolase 1
, Transaldolase 1
, dihydroxyacetone transferase
, glycerone transferase