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TTPA encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. Zusätzlich bieten wir Ihnen TTPA Antikörper (29) und TTPA Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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These findings provide the basis for a proposed mechanistic model that describes TTP (zeige ADAMTS13 ELISA Kits)-facilitated trafficking of alpha-tocopherol through hepatocytes.
Single-nucleotide polymorphisms that are commonly found in healthy humans dramatically affect promoter activity of the TTPA gene.
The crystal structure of the alpha-TTP-phosphatidylinositol phosphates (PIPs (zeige GPRASP1 ELISA Kits)) complex revealed that the familial vitamin E deficiency-related arginine residues interacted with phosphate groups of the PIPs (zeige GPRASP1 ELISA Kits) and that the PIPs (zeige GPRASP1 ELISA Kits) binding caused the lid of the alpha-tocopherol-binding pocket to open.
Data show that reduction ("knockdown") of tocopherol transfer protein (TTP (zeige ADAMTS13 ELISA Kits)) expression resulted in resistance to the vitamin E.
Substitution of residues in helices A8 (F165A and F169A) and A10 (I202A, V206A and M209A) decreased the rate of intermembrane ligand transfer as well as protein adsorption to phospholipid bilayers.
First case of a mutated form of the TTPA gene in a patient also carrying a spinocerebellar ataxia type 8 expansion.
the positively charged surface of TTPA may serve to orient an interacting protein, which might function to regulate the release of alpha-T through an induced change in conformation of ATTP
Findings suggest the possibility that ataxia with vitamin E deficiency syndrome (AVED) may not arise from an inability of TTP (zeige ADAMTS13 ELISA Kits) to bind or to transfer alpha tocopherol, but rather from defects in other activities of the protein.
Nuclear localization of TTPA in in trophoblast, fetal capillaries' endothelium and amnion epithelium of human term placentamay represent a novel function of TTPA
In Ataxia with vitamin E deficiency two TTPA mutations were identified: a truncating mutation in a homozygous patient, and a Gly246Arg missense mutation in a compound heterozygous patient associated with a mild and slowly progressive form of the disease.
Results suggest that lipid peroxidation due to depletion of alpha-tocopherol impairs Abeta (zeige APP ELISA Kits) clearances from the brain and from the blood, possibly causing increased Abeta (zeige APP ELISA Kits) accumulation in Ttpa(-/-)APPsw brain and plasma.
Endogenous TTPA, through the enhancement of MMP 9 (zeige MMP9 ELISA Kits) expression and proteolytic activation, plays an essential role in the pathogenesis of heparin-produced cerebral hemorrhage.
TTP (zeige ZFP36 ELISA Kits) transports alpha-TCP and oral administration of TTP (zeige ZFP36 ELISA Kits) compensates for TTP (zeige ZFP36 ELISA Kits) in TTP (zeige ZFP36 ELISA Kits)-deficient mice
These data suggest that in vivo network of alpha-tocopherol (AT), AT-metabolites and ATTP affects the transcription of genes driven by AhR (zeige AHR ELISA Kits), Nrf2 (zeige NFE2L2 ELISA Kits) and NF-kappaB (zeige NFKB1 ELISA Kits), transcription factor networks.
p75(NTR (zeige NGFR ELISA Kits))is up-regulated after tissue injury, blocks fibrinolysis by down-regulating the serine protease (zeige F2 ELISA Kits), tissue plasminogen activator (zeige PLAT ELISA Kits), and up-regulating PAI-1 (zeige SERPINE1 ELISA Kits).
changes in hepatic TTP (zeige ZFP36 ELISA Kits) concentrations were minimal in response to dietary vitamin E levels or environmental tobacco smoke-related oxidative stress
Increase expression of tPA implicate fibrinolysis in ALD progression.
This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.
alpha-tocopherol transfer protein
, tocopherol (alpha) transfer protein
, tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)
, Alpha-tocopherol transfer protein
, Tocopherol transfer protein alpha
, alpha TTP