anti-Titin-Cap (Telethonin) (TCAP) Antikörper

Sarcomere assembly is regulated by the muscle protein titin. Zusätzlich bieten wir Ihnen TCAP Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TCAP 8557 O15273
TCAP 21393 O70548
TCAP 688173  
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Top anti-TCAP Antikörper auf antikoerper-online.de

Showing 10 out of 34 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-TCAP Antibody Titration: 5.0ug/mlPositive Control: HepG2 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
288,68 €
Details
Human Maus Unkonjugiert WB Western blot analysis of Telethonin of mouse heart lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of Telethonin. 50 μg Anmelden zum Anzeigen 2 bis 4 Tage
146,73 €
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
583,17 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Kaninchen Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
374,52 €
Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged TCAP is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 12 bis 16 Tage
454,76 €
Details
Human Kaninchen Unkonjugiert IC, IF, WB Immunofluorescent analysis of Telethonin staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary anti Western blot analysis of Telethonin expression in mouse heart (A), rat heart (B), rat skeletal muscle (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (36.74 KDa) . 200 μL Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cell lines, using TCAP antibody. Immunofluorescence analysis of HeLa cell using TCAP antibody. Blue: DAPI for nuclear staining. 100 μL Anmelden zum Anzeigen 12 Days
261,90 €
Details

TCAP Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
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Am meisten referenzierte anti-TCAP Antikörper

  1. Human Monoclonal TCAP Primary Antibody für WB - ABIN968822 : Mason, Bayol, Loughna: The novel sarcomeric protein telethonin exhibits developmental and functional regulation. in Biochemical and biophysical research communications 1999 (PubMed)
    Zeige alle 4 Referenzen für 968822

  2. Cow (Bovine) Polyclonal TCAP Primary Antibody für WB - ABIN2783290 : Bos, Theis, Tajik, Gersh, Ommen, Ackerman: Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. in American heart journal 2008 (PubMed)

Weitere Antikörper gegen TCAP Interaktionspartner

Zebrafish Titin-Cap (Telethonin) (TCAP) Interaktionspartner

  1. Data show show that tcap is functionally conserved and reduction of Tcap resulted in muscular dystrophy-like phenotypes including deformed muscle structure and impaired swimming ability.

Xenopus laevis Titin-Cap (Telethonin) (TCAP) Interaktionspartner

  1. Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance.

Human Titin-Cap (Telethonin) (TCAP) Interaktionspartner

  1. Data indicate LGMD2G protein TCAP association with limb girdle muscular dystrophy 2G (LGMD2G).

  2. Report TCAP mutations in dilated cardiomyopathy.

  3. cardiac telethonin is constitutively bis (zeige BAG3 Antikörper)-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2 (zeige CA2 Antikörper)+) transients.

  4. This study identified no pathogenic mutations in BAG3 (zeige BAG3 Antikörper), MATR3 (zeige MATR3 Antikörper), PTRF (zeige PTRF Antikörper) or TCAP in Australian muscular dystrophy.

  5. reduced expression of dystrophin (zeige DMD Antikörper) and titin (zeige TTN Antikörper) is associated with the pathophysiology of dilated cardiomyopathy, and TNF-alpha (zeige TNF Antikörper) may modulate the expression of these proteins via NF-kappaB (zeige NFKB1 Antikörper) pathway.

  6. Genetic studies of tcap in zebrafish suggested that pathogenesis in LGMD2G is due to a disruption of sarcomere-T-tubular interaction, but not of sarcomere assembly per se.

  7. review of telethonin and other new proteins of the Z-disc of skeletal muscle

  8. telethonin protein levels seems to be at least in part regulated by neuronal activity and is thus linked to the dynamic control of myofibrillogenesis and muscle turnover in human skeletal muscle.

  9. telethonin may play a role in linking titin (zeige TTN Antikörper) filaments at the Z-disk periphery

  10. TCAP mutations identified which are associated with hypertrophic cardiomyopathy.

Mouse (Murine) Titin-Cap (Telethonin) (TCAP) Interaktionspartner

  1. cardiac telethonin is constitutively bis (zeige BAG3 Antikörper)-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2 (zeige CA2 Antikörper)+) transients.

  2. Tcap is a critical, load-sensitive regulator of t-tubule structure and function.

  3. Telethonin knockout mice develop heart failure following biomechanical stress, owing at least in part to apoptosis of cardiomyocytes, an effect that may also play a role in human heart failure.

  4. Whereas both promotor E boxes in Tcap are required for full activation by MyoD (zeige MYOD1 Antikörper) or myogenin (zeige MYOG Antikörper) in NIH3T3 cells, the promoter proximal E box has a greater contribution to activation in C2C12 cells and to activation by MyoD (zeige MYOD1 Antikörper) in NIH3T3 cells.

  5. Findings suggest that TCAP knockdown with RNA interference alters normal muscle cell differentiation.

Pig (Porcine) Titin-Cap (Telethonin) (TCAP) Interaktionspartner

  1. TCAP promoter can be activated by MyoD (zeige MYOD1 Antikörper), MyoG (zeige MYOG Antikörper) and MEF2 (zeige MYEF2 Antikörper) in myotubes, which indicated that TCAP may play a role in the regulation of skeletal muscle development.

TCAP Antigen-Profil

Protein Überblick

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.

Genbezeichner und Symbole assoziert mit TCAP

  • titin-cap (telethonin) (TCAP) Antikörper
  • titin-cap (telethonin) (tcap) Antikörper
  • titin-cap (TCAP) Antikörper
  • titin-cap (Tcap) Antikörper
  • AI503981 Antikörper
  • AJ223855 Antikörper
  • CMD1N Antikörper
  • LGMD2G Antikörper
  • T-cap Antikörper
  • TCAP Antikörper
  • TELE Antikörper
  • telethonin Antikörper

Bezeichner auf Proteinebene für TCAP

titin-cap (telethonin) , 19 kDa sarcomeric protein , limb girdle muscular dystrophy 2G (autosomal recessive) , telethonin , titin cap protein , titin-cap protein

GENE ID SPEZIES
454633 Pan troglodytes
556258 Danio rerio
697327 Macaca mulatta
100380097 Xenopus (Silurana) tropicalis
100381005 Xenopus laevis
8557 Homo sapiens
608508 Canis lupus familiaris
21393 Mus musculus
688173 Rattus norvegicus
100271745 Sus scrofa
513257 Bos taurus
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