anti-Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Antikörper

TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. Zusätzlich bieten wir Ihnen TJP2 Kits (6) und TJP2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TJP2 9414 Q9UDY2
TJP2 21873 Q9Z0U1
TJP2 115769  
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Showing 10 out of 105 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Hund Kaninchen Unkonjugiert WB WB Suggested Anti-TJP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: MCF7 cell lysate WB Suggested Anti-TJP2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: MCF7 cell lysate  TJP2 is supported by BioGPS gene expression data to be expressed in MCF7 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-TJP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Maus Kaninchen Unkonjugiert IHC (p), WB Anti-TJP2 antibody, IHC(P) IHC(P): Mouse Liver Tissue Anti-TJP2 antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: PC-12 Cell Lysate Lane 3: Mouse Brain Tissue Lysate Lane 4: HEPA Cell Lysate 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
298,57 €
Details
Human Kaninchen Unkonjugiert IHC (fro), IHC (p), WB Anti-TJP2 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti-TJP2 antibody, Western blotting Lane 1: 293T Cell Lysate Lane 2: MCF-7 Cell Lysate 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
298,57 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: Tight Junction Protein 2 Antibody  - Analysis in human cell line A-431. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Human Kaninchen Unkonjugiert DB Dot blot analysis of Phospho-PTEN-Y240 Antibody Phospho-specific Pab  on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: U87-MG 5% SDS PAGE antibody diluted at 1:500 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
Details
Human Kaninchen Unkonjugiert WB TJP2 Antibody (C-term)  western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the TJP2 antibody detected the TJP2 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Hund Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
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Huhn Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
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TJP2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine)
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Rat (Rattus)


Am meisten referenzierte anti-TJP2 Antikörper

  1. Human Polyclonal TJP2 Primary Antibody für ICC, IF - ABIN4359740 : González-Andrades, Garzón, Gascón, Muñoz-Avila, Sánchez-Quevedo, Campos, Alaminos: Sequential development of intercellular junctions in bioengineered human corneas. in Journal of tissue engineering and regenerative medicine 2009 (PubMed)
    Zeige alle 2 Referenzen für 4359740

  2. Cow (Bovine) Polyclonal TJP2 Primary Antibody für WB - ABIN2775643 : Bel Hadj Ali, Thys, Beltaief, Schrauwen, Hilgert, Vanderstraeten, Dieltjens, Mnif, Hachicha, Besbes, Ben Arab, Van Camp: A new locus for otosclerosis, OTSC8, maps to the pericentromeric region of chromosome 9. in Human genetics 2008 (PubMed)

Weitere Antikörper gegen TJP2 Interaktionspartner

Human Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Interaktionspartner

  1. Patients with a confirmed ABCB11 (zeige ABCB11 Antikörper) or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 (zeige ATP8B1 Antikörper) mutation had an elevated THBA proportion (7.51-37.26%).

  2. Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors.

  3. Data identified two Disease-causing Genes TJP2 and GJB2 (zeige GJB2 Antikörper) in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.

  4. TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood

  5. Claudin-19 (zeige CLDN19 Antikörper), the most abundant claudin in myelin, exhibited no binding to ZO2.

  6. JAM-A (zeige F11R Antikörper) regulates epithelial permeability via association with ZO-2, afadin (zeige MLLT4 Antikörper), and PDZ-GEF1 (zeige RAPGEF2 Antikörper) to activate Rap2c (zeige RAP2C Antikörper) and control contraction of the apical cytoskeleton.

  7. Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.

  8. demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP (zeige MMP14 Antikörper)

  9. the Alu-related transcript of TJP2 gene (TJP2-Alu transcript) was differentially expressed between colorectal tumor and normal tissues; potential diagnostic markers for colorectal cancer.

  10. ZO-2 inhibits the Wnt (zeige WNT2 Antikörper) signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.

Mouse (Murine) Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Interaktionspartner

  1. Expression of Podocalyxin (zeige PODXL Antikörper), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 (zeige TJP1 Antikörper) and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin (zeige EZR Antikörper).

  2. SNX27 (zeige SNX27 Antikörper) associates with ZO-2 and modulates the epithelial tight junction.

  3. ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathway

  4. the first PDZ domain (zeige INADL Antikörper) of ZO-2 interacts with YAP2 (zeige YAP1 Antikörper) to form complex; ZO-2 facilitates both nuclear translocation of YAP2 (zeige YAP1 Antikörper) & pro-apoptotic function of YAP2 (zeige YAP1 Antikörper); these activities of ZO-2 are PDZ-domain (zeige INADL Antikörper)-dependent

  5. Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.

  6. nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions

  7. ZO-1 (zeige TJP1 Antikörper) and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical

  8. These findings indicate that ZO-1 (zeige TJP1 Antikörper) and ZO-2 can independently determine whether and where claudins are polymerized.

  9. These results suggest novel roles for ZO proteins as Src (zeige SRC Antikörper)/Csk (zeige CSK Antikörper) scaffolds potentially involved in the regulation of Src (zeige SRC Antikörper) transformation.

  10. Early embryonic lethality of mice lacking Tjp2, but not Tjp3 (zeige TJP3 Antikörper), reveal critical and nonredundant roles for individual zonula occludens proteins in mammalian development.

TJP2 Antigen-Profil

Protein Überblick

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit TJP2

  • tight junction protein 2 (TJP2) Antikörper
  • tight junction protein 2 (Tjp2) Antikörper
  • tight junction protein 2 (zona occludens 2) (TJP2) Antikörper
  • C9DUPq21.11 Antikörper
  • DFNA51 Antikörper
  • DUP9q21.11 Antikörper
  • X104 Antikörper
  • ZO-2 Antikörper
  • zo2 Antikörper

Bezeichner auf Proteinebene für TJP2

tight junction protein 2 (zona occludens 2) , Friedreich ataxia region gene X104 (tight junction protein ZO-2) , tight junction protein ZO-2 , zona occludens 2 , zonula occludens protein 2 , Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2) , zona occludens protein 2

GENE ID SPEZIES
100229218 Taeniopygia guttata
9414 Homo sapiens
21873 Mus musculus
115769 Rattus norvegicus
100729549 Cavia porcellus
395751 Gallus gallus
403854 Canis lupus familiaris
407101 Bos taurus
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