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regulates thyroid gland function\; mediates phospholipase C activation and increased intracellular calcium [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen TRHR Kits (5) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal TRHR Primary Antibody für IF, ELISA - ABIN1536075
Liu, Ha, Cui, Wang, Yan, Fu, Quan, Zhou, Yang: JNK pathway decreases thyroid hormones via TRH receptor: A novel mechanism for disturbance of thyroid hormone homeostasis by PCB153. in Toxicology 2012
Show all 3 Pubmed References
Dog (Canine) Polyclonal TRHR Primary Antibody für IHC (p) - ABIN270556
Xiao, Segal: Biological sequence classification utilizing positive and unlabeled data. in Bioinformatics (Oxford, England) 2008
Human Polyclonal TRHR Primary Antibody für IHC (p) - ABIN2476943
García, Porto, Dieuzeide, Landa, Kirszner, Plotquin, Gonzalez, Pirola: Thyrotropin-releasing hormone receptor (TRHR) gene is associated with essential hypertension. in Hypertension 2001
activating TRH/TRH (zeige TRH Antikörper)-R1 signaling seems not to be sufficient for gastric stimulation of acylated ghrelin (zeige GHRL Antikörper) production
The central nervous systems effects of taltirelin are mediated primarily by TRH-R1 and not TRH (zeige TRH Antikörper)-R2.
We suggest that persistent signaling by TRHRs is exhibited when sufficient levels of agonist/receptor/G-protein complexes are established and maintained and that TRH (zeige TRH Antikörper)-R2 forms and maintains these complexes more efficiently than TRH-R1.
three distinct and discontinuous regions of the TSHR (aa 246-260 and 277-296 on the TSHR A subunit) and aa 381-385 (on the TSHR B subunit) fold together to form a complex TSH binding pocket.
the TSHR (zeige TSHR Antikörper) may not be similar to other model proteins used to define the concept of central immune tolerance.
TRH-R1 has a role in mouse lactation and mice lacking the receptor show signs of central hypothyroidism
Thyrotropin-releasing hormone (zeige TRH Antikörper) binding induces separation of cytoplasmic ends of TRH receptor type 1 transmembrane helix 5 (TMH5) and TMH6 and a rotation of TMH6 that could promote interactions between G proteins and key residues within the TRH receptor.
Beta-arrestin has a role in desensitization and internalization but not phosphorylation of the thyrotropin-releasing hormone receptor, which causes translocation of endogenous GRK2 (zeige ADRBK1 Antikörper) to the plasma membrane
the endogenous TRH (zeige TRH Antikörper) system is involved in mood regulation, and this function is carried out through TRH-R1-mediated neural pathways
A flexible molecular docking procedure revealed that TRH (zeige TRH Antikörper) establishes a direct interaction with W6.48 in TRH (zeige TRH Antikörper)-R2 but not in TRH-R1.
a unique missense TRHR defect identified in a consanguineous family is associated with central hypothyroidism in homozygotes and hyperthyrotropinemia in heterozygotes, suggesting compensatory elevation of TSH with reduced biopotency; the I131T mutation decreases TRH (zeige TRH Antikörper) binding and TRHR-Gq coupling and signaling
rs16892496 polymorphism in the TRHR gene may play a role in FFM (zeige ABCA4 Antikörper) variation.
The precoupling of receptors with their cognate G-proteins can contribute to faster G-protein activation and subsequent signal transfer into the cell interior.
Data show that interactions of TRHR with GRKs and phosphatases are determined not simply by the amino acid sequences of the substrates, but by regions outside the cytoplasmic tails.
A mutation in thyrotropin-releasing hormone receptor almost completely prevented receptor phosphorylation.
TRH receptor in adenoma cells plays an important role in the paradoxical GH response to TRH (zeige TRH Antikörper) administration in GH cell adenomas.
Controlled dimerization of the TRH receptor potentiates hormone-induced receptor trafficking.
TRHR gene is an important gene for LBM variation.
analysis of the effect of subcellular trafficking of the TRH receptor
Distribution of the mRNAs encoding proTRH and the three TRH (zeige TRH Antikörper) receptors in the central nervous system and pituitary of X. laevis is described.
TRHR (pTRHR) gene was localized to chromosome 4; full-length cDNA of pTRHR was cloned and sequenced; pTRHR contains an open reading frame encoding 398 amino acids and shares 96.2% amino acid identity to human TRHR.
regulates thyroid gland function\; mediates phospholipase C activation and increased intracellular calcium
thyrotropin-releasing hormone receptor
, thyroliberin receptor
, thyrotropin releasing hormone receptor