Thymic Stromal Lymphopoietin Proteine (TSLP)

TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Zusätzlich bieten wir Ihnen Thymic Stromal Lymphopoietin Antikörper (195) und Thymic Stromal Lymphopoietin Kits (83) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TSLP 85480 Q969D9
TSLP 53603 Q9JIE6
TSLP 688621  
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Showing 10 out of 42 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Escherichia coli (E. coli) Maus Unkonjugiert 4 pack Anmelden zum Anzeigen 10 bis 12 Tage
$86.96
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Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 10 bis 12 Tage
$201.11
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Escherichia coli (E. coli) Human Unkonjugiert   0.01 mg Anmelden zum Anzeigen 2 bis 6 Tage
$324.50
Details
Escherichia coli (E. coli) Human Unkonjugiert   4 pack Anmelden zum Anzeigen 10 bis 12 Tage
$86.96
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Escherichia coli (E. coli) Human Unkonjugiert 10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$85.00
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Escherichia coli (E. coli) Human Unkonjugiert Validation with Western Blot 10 μg Anmelden zum Anzeigen 12 bis 15 Tage
$229.85
Details
Mammalian Cells Maus Fc Tag   50 μg Anmelden zum Anzeigen 4 Days
$329.18
Details

TSLP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) , , , ,
, ,
Rat (Rattus)

Weitere Proteine zu Thymic Stromal Lymphopoietin (TSLP) Interaktionspartnern

Human Thymic Stromal Lymphopoietin (TSLP) Interaktionspartner

  1. The results suggest that IL-1beta (zeige IL1B Proteine) may be an early key mediator for the acquisition of an Atopic dermatitis (AD) phenotype through induction of thymic stromal lymphopoietin (TSLP) and alteration of the epidermal homeostasis.

  2. House dust mite exposure increases the expression of TSLP through PI3K/Akt signalin (zeige CDH1 Proteine)g pathway in human bronc (zeige HDAC3 Proteine)hial epithelial 16HBE cells.

  3. Posttranslational modifications control the functional activity of TSLP in humans and overproduction of TSLP may be a key trigger for the amplification of type 2 inflammation in diseases

  4. Study provides evidence for the hypothesis that TSLP could reflect the histological severity of lumbar disc degeneration (LDD), and TSLP-siRNA and TSLPR (zeige CRLF2 Proteine)-siRNA could inhibit apoptosis of nucleus pulposus cells. The evident information obtained from the investigation could lead the way for new therapeutic approaches regarding LDD treatment.

  5. periostin (zeige POSTN Proteine)-mediated TSLP production by keratinocytes directly stimulates cutaneous T-cell lymphoma (CTCL) tumor (zeige EEF1A1 Proteine) cell growth in addition to inducing a Th2-dominant tumor environment in CTCL (zeige TSPYL2 Proteine).

  6. this study shows that TSLP may be involved in the pathogenesis of asthma and rhinitis; dust mite and mugwort allergy could increase it significantly

  7. Serum TSLP levels were significantly increased in systemic sclerosis patients compared to healthy donors, and were associated with a higher frequency of vasculopathy. The proportion of TSLP-positive dermal cells was increased in the skin of SSc (zeige CYP11A1 Proteine) patients compared with healthy donors, and was correlated with fibrosis.

  8. this study shows that NOD2 is an asthma-related factor that can promote cell proliferation and inflammatory response by mediated expression of TSLP in human airway smooth muscle cells

  9. the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation.

  10. interactions between TSLP in follicular dendritic cells and IgA production in tonsils may be an important mechanism contributing to the pathogenesis of Immunoglobulin A (IgA) nephropathy.

Mouse (Murine) Thymic Stromal Lymphopoietin (TSLP) Interaktionspartner

  1. study concludes that IL-33 (zeige IL33 Proteine) and TSLP are required for epithelial cell IL-25 (zeige IL25 Proteine) expression, mucous metaplasia, and ILC2 expansion following early-life rhinovirus infection

  2. TSLP plays a role in dysfunction of airway epithelial adherens junctions E-cadherin (zeige CDH1 Proteine) in house dust mite (HDM (zeige HDAC3 Proteine))-induced asthma. Mice treated with an anti-TSLP mAb ameliorated airway inflammation, the decreasing and aberrant distribution of E-cadherin (zeige CDH1 Proteine) and beta-catenin (zeige CTNNB1 Proteine) as well as phosphorylation(p)-AKT (zeige AKT1 Proteine) induced by HDM (zeige HDAC3 Proteine). In vitro, HDM (zeige HDAC3 Proteine) increased the expression of TSLP and E-cadherin (zeige CDH1 Proteine) dysfunction by PI3K/Akt (zeige AKT1 Proteine) signaling pathway.

  3. this study shows that TSLP is a key target of Mi-2beta (zeige CHD4 Proteine) in keratinocytes, and that loss of TSLP signaling in regulatory T cells prevents their activation

  4. These data demonstrate that multiple pathogenic strains of RSV induce IL-13 (zeige IL13 Proteine)-producing group 2 innate lymphoid cell proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection.

  5. the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation.

  6. The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23 (zeige IL23A Proteine)/type 17 axes.

  7. this study shows that activation of primed TH2 cells occurs independently of group 2 innate lymphoid cells or their cytokines but that the effector function of both cell types was dependent on combinatorial exposure to IL-33 (zeige IL33 Proteine), IL-25 (zeige IL25 Proteine) and TSLP

  8. TNF-alpha (zeige TNF Proteine) and IL-1beta (zeige IL1B Proteine), which are partly produced by LPS (zeige TLR4 Proteine)-activated leukocytes, contribute to TSLP production via TLR4 (zeige TLR4 Proteine) activation in vivo.

  9. IL-33 (zeige IL33 Proteine)-ERK (zeige EPHB2 Proteine)/JNK (zeige MAPK8 Proteine)/p38 (zeige CRK Proteine)/Egr-1 (zeige EGR1 Proteine)/TSLP axis involved in allergic skin Th2 inflammation

  10. Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR (zeige CRLF2 Proteine)-Ig improves ALI at least in part by regulation of dendritic cell functions.

Thymic Stromal Lymphopoietin (TSLP) Protein Überblick

Protein Überblick

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit TSLP

  • thymic stromal lymphopoietin (TSLP)
  • thymic stromal lymphopoietin (Tslp)
  • TSLP Protein

Bezeichner auf Proteinebene für TSLP

thymic stromal lymphopoietin , thymic stromal lymphopoetin , thymic stroma-derived lymphopoietin

GENE ID SPEZIES
706194 Macaca mulatta
737202 Pan troglodytes
100302635 Equus caballus
85480 Homo sapiens
53603 Mus musculus
688621 Rattus norvegicus
101788673 Cavia porcellus
607671 Canis lupus familiaris
617637 Bos taurus
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