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TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Zusätzlich bieten wir Ihnen Thymic Stromal Lymphopoietin Antikörper (179) und Thymic Stromal Lymphopoietin Kits (80) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 41 products:
Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666980
Mazzucchelli, Hixon, Spolski, Chen, Li, Hall, Willette-Brown, Hurwitz, Leonard, Durum: Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. in Blood 2008
Zeige alle 7 Referenzen für ABIN2666980
Mouse (Murine) TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2667598
Nguyen, Vanichsarn, Nadeau: TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway. in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2010
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Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666676
Omori, Ziegler: Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. in Journal of immunology (Baltimore, Md. : 1950) 2007
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Mouse (Murine) TSLP Protein expressed in Human Cells - ABIN2008516
Liu, Soumelis, Watanabe, Ito, Wang, Malefyt, Omori, Zhou, Ziegler: TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. in Annual review of immunology 2007
Study demonstrated that naturally occurring severe infections by the most common respiratory viruses in hospitalized infants induce nasal airway secretion of TSLP, IL-33 (zeige IL33 Proteine), and periostin (zeige POSTN Proteine) when compared with healthy controls
Variations in FLG (zeige FGFR1 Proteine) and TSLP genotype were associated with differences in self-reported skin clearance, TCI (zeige LXN Proteine) usage, and steroid usage.
A possible role of TSLP in immune homeostasis in HIV infection:higher plasma TSLP was found in individuals with primary HIV infection compared to both chronic HIV infection and healthy controls.
The polymorphism was further reproducibly associated with a DNA methylation (zeige HELLS Proteine) signature in whole blood (P = 4.5x10-40) that also associated with allergic sensitization and expression in blood of the cytokine TSLP (P = 1.1x10-4). Knockdown of the transcription factor predicted to bind the enhancer region (NHLH1 (zeige NHLH1 Proteine)) in a human cell line (HEK293) expressing NHLH1 (zeige NHLH1 Proteine) resulted in lower TSLP expression
TSLP level was significantly higher in asthmatic than in nonasthmatic children. TSLP level was significantly different between allergic asthmatic and nonallergic nonasthmatic groups.
While serum TSLP levels were unaffected by concomitant allergies and atopic comorbidities, serum levels of IL-31 (zeige IL31 Proteine), IL-33 (zeige IL33 Proteine) and sST2 (zeige SSTR2 Proteine) were affected to a small extent. We found a positive correlation between TSLP, IL-31 (zeige IL31 Proteine) and IL-33 (zeige IL33 Proteine), and an inverse relationship between IL-33 (zeige IL33 Proteine) and sST2 (zeige SSTR2 Proteine)
Results showed that TSLP promoted the production of alpha-SMA (zeige SMN1 Proteine) and collagen I (P<0.001), suggesting that it can accelerate MRC-5 cell fibrosis.
Chronic rhinosinusitis with nasal polyps (CRSwNP) epithelial cells release TSLP and IL-25 (zeige IL25 Proteine) when stimulated by poly(I:C) but not by DP or AF, suggesting that viral infection may contribute to maintain and amplify the T2 immune response seen in CRSwNP.
TSLP is a key mediator in the pathogenesis of inflammatory bowel diseases and that further studies are needed to evaluate its role. [review]
Letter: report decreased salivary gland TSLP expression in primary Sjogren's syndrome.
The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23 (zeige IL23A Proteine)/type 17 axes.
this study shows that activation of primed TH2 cells occurs independently of group 2 innate lymphoid cells or their cytokines but that the effector function of both cell types was dependent on combinatorial exposure to IL-33 (zeige IL33 Proteine), IL-25 (zeige IL25 Proteine) and TSLP
TNF-alpha (zeige TNF Proteine) and IL-1beta (zeige IL1B Proteine), which are partly produced by LPS (zeige TLR4 Proteine)-activated leukocytes, contribute to TSLP production via TLR4 (zeige TLR4 Proteine) activation in vivo.
IL-33 (zeige IL33 Proteine)-ERK (zeige EPHB2 Proteine)/JNK (zeige MAPK8 Proteine)/p38 (zeige CRK Proteine)/Egr-1 (zeige EGR1 Proteine)/TSLP axis involved in allergic skin Th2 inflammation
Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR (zeige CRLF2 Proteine)-Ig improves ALI at least in part by regulation of dendritic cell functions.
TSLP expression in the skin is mediated via RARgamma-RXR pathways.
results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers.
Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice
production by monocyte-derived dendritic cells requires the integration of signals from dectin-1 (zeige CLEC7A Proteine), the IL-1 (zeige IL1A Proteine) receptor, and endoplasmic reticulum stress response stress signaling pathways
Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand (zeige TNFSF4 Proteine), thymic stromal lymphopoietin, and IL-33 (zeige IL33 Proteine)
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.
thymic stromal lymphopoietin
, thymic stromal lymphopoetin
, thymic stroma-derived lymphopoietin