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Thymic Stromal Lymphopoietin Proteine (TSLP)

TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Zusätzlich bieten wir Ihnen Thymic Stromal Lymphopoietin Antikörper (179) und Thymic Stromal Lymphopoietin Kits (80) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TSLP 85480 Q969D9
TSLP 53603 Q9JIE6
TSLP 688621  
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Showing 10 out of 41 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Maus Unkonjugiert 4 pack Anmelden zum Anzeigen 6 bis 8 Tage
82,82 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
191,53 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   4 pack Anmelden zum Anzeigen 6 bis 8 Tage
82,82 €
Details
HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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HOST_Mammalian Cells Maus Fc Tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
341,00 €
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HOST_Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
640,00 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 6 bis 8 Tage
977,78 €
Details

TSLP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) , , , ,
, ,
Rat (Rattus)

Am meisten referenzierte Thymic Stromal Lymphopoietin Proteine

  1. Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666980 : Mazzucchelli, Hixon, Spolski, Chen, Li, Hall, Willette-Brown, Hurwitz, Leonard, Durum: Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. in Blood 2008 (PubMed)
    Zeige alle 7 Referenzen für ABIN2666980

  2. Mouse (Murine) TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2667598 : Nguyen, Vanichsarn, Nadeau: TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway. in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2010 (PubMed)
    Zeige alle 7 Referenzen für ABIN2667598

  3. Human TSLP Protein expressed in Escherichia coli (E. coli) - ABIN2666676 : Omori, Ziegler: Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Zeige alle 7 Referenzen für ABIN2666676

  4. Mouse (Murine) TSLP Protein expressed in Human Cells - ABIN2008516 : Liu, Soumelis, Watanabe, Ito, Wang, Malefyt, Omori, Zhou, Ziegler: TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. in Annual review of immunology 2007 (PubMed)

Weitere Proteine zu Thymic Stromal Lymphopoietin (TSLP) Interaktionspartnern

Human Thymic Stromal Lymphopoietin (TSLP) Interaktionspartner

  1. Study demonstrated that naturally occurring severe infections by the most common respiratory viruses in hospitalized infants induce nasal airway secretion of TSLP, IL-33 (zeige IL33 Proteine), and periostin (zeige POSTN Proteine) when compared with healthy controls

  2. Variations in FLG (zeige FGFR1 Proteine) and TSLP genotype were associated with differences in self-reported skin clearance, TCI (zeige LXN Proteine) usage, and steroid usage.

  3. A possible role of TSLP in immune homeostasis in HIV infection:higher plasma TSLP was found in individuals with primary HIV infection compared to both chronic HIV infection and healthy controls.

  4. The polymorphism was further reproducibly associated with a DNA methylation (zeige HELLS Proteine) signature in whole blood (P = 4.5x10-40) that also associated with allergic sensitization and expression in blood of the cytokine TSLP (P = 1.1x10-4). Knockdown of the transcription factor predicted to bind the enhancer region (NHLH1 (zeige NHLH1 Proteine)) in a human cell line (HEK293) expressing NHLH1 (zeige NHLH1 Proteine) resulted in lower TSLP expression

  5. TSLP level was significantly higher in asthmatic than in nonasthmatic children. TSLP level was significantly different between allergic asthmatic and nonallergic nonasthmatic groups.

  6. While serum TSLP levels were unaffected by concomitant allergies and atopic comorbidities, serum levels of IL-31 (zeige IL31 Proteine), IL-33 (zeige IL33 Proteine) and sST2 (zeige SSTR2 Proteine) were affected to a small extent. We found a positive correlation between TSLP, IL-31 (zeige IL31 Proteine) and IL-33 (zeige IL33 Proteine), and an inverse relationship between IL-33 (zeige IL33 Proteine) and sST2 (zeige SSTR2 Proteine)

  7. Results showed that TSLP promoted the production of alpha-SMA (zeige SMN1 Proteine) and collagen I (P<0.001), suggesting that it can accelerate MRC-5 cell fibrosis.

  8. Chronic rhinosinusitis with nasal polyps (CRSwNP) epithelial cells release TSLP and IL-25 (zeige IL25 Proteine) when stimulated by poly(I:C) but not by DP or AF, suggesting that viral infection may contribute to maintain and amplify the T2 immune response seen in CRSwNP.

  9. TSLP is a key mediator in the pathogenesis of inflammatory bowel diseases and that further studies are needed to evaluate its role. [review]

  10. Letter: report decreased salivary gland TSLP expression in primary Sjogren's syndrome.

Mouse (Murine) Thymic Stromal Lymphopoietin (TSLP) Interaktionspartner

  1. The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23 (zeige IL23A Proteine)/type 17 axes.

  2. this study shows that activation of primed TH2 cells occurs independently of group 2 innate lymphoid cells or their cytokines but that the effector function of both cell types was dependent on combinatorial exposure to IL-33 (zeige IL33 Proteine), IL-25 (zeige IL25 Proteine) and TSLP

  3. TNF-alpha (zeige TNF Proteine) and IL-1beta (zeige IL1B Proteine), which are partly produced by LPS (zeige TLR4 Proteine)-activated leukocytes, contribute to TSLP production via TLR4 (zeige TLR4 Proteine) activation in vivo.

  4. IL-33 (zeige IL33 Proteine)-ERK (zeige EPHB2 Proteine)/JNK (zeige MAPK8 Proteine)/p38 (zeige CRK Proteine)/Egr-1 (zeige EGR1 Proteine)/TSLP axis involved in allergic skin Th2 inflammation

  5. Suggest that TSLP may be involved in acute lung injury, and blockage of TSLP signaling using TSLPR (zeige CRLF2 Proteine)-Ig improves ALI at least in part by regulation of dendritic cell functions.

  6. TSLP expression in the skin is mediated via RARgamma-RXR pathways.

  7. results highlight a previously unappreciated function of the immune system in controlling the early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunity against early-stage cancers.

  8. Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice

  9. production by monocyte-derived dendritic cells requires the integration of signals from dectin-1 (zeige CLEC7A Proteine), the IL-1 (zeige IL1A Proteine) receptor, and endoplasmic reticulum stress response stress signaling pathways

  10. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand (zeige TNFSF4 Proteine), thymic stromal lymphopoietin, and IL-33 (zeige IL33 Proteine)

Thymic Stromal Lymphopoietin (TSLP) Protein Überblick

Protein Überblick

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit TSLP

  • thymic stromal lymphopoietin (TSLP)
  • thymic stromal lymphopoietin (Tslp)
  • uncharacterized LOC617637 (LOC617637)
  • TSLP Protein

Bezeichner auf Proteinebene für TSLP

thymic stromal lymphopoietin , thymic stromal lymphopoetin , thymic stroma-derived lymphopoietin

GENE ID SPEZIES
706194 Macaca mulatta
737202 Pan troglodytes
100302635 Equus caballus
85480 Homo sapiens
53603 Mus musculus
688621 Rattus norvegicus
101788673 Cavia porcellus
607671 Canis lupus familiaris
617637 Bos taurus
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