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Involved in the metabolism of neuropeptides under 20 amino acid residues long. Zusätzlich bieten wir Ihnen Thimet Oligopeptidase 1 Kits (17) und Thimet Oligopeptidase 1 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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Monoclonal Thimet Oligopeptidase 1 Primary Antibody für IF, WB - ABIN534015
Conn, Pietropaolo, Ju, Abraham: Monoclonal antibodies against the human metalloprotease EC 18.104.22.168 label neurofibrillary tangles in Alzheimer's disease brain. in Journal of neurochemistry 1997
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Human Monoclonal Thimet Oligopeptidase 1 Primary Antibody für ICC, IF - ABIN152914
Azizi, Kang, Freilinger, Gruber-Olipitz, Chen, Yang, Hengstschläger, Slavc, Lubec: Mitosis-dependent protein expression in neuroblastoma cell line N1E-115. in Journal of proteome research 2008
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Data suggest that three new candidate genes involved in the development of rheumatoid arthritis (RA): ERBB2 (zeige ERBB2 Antikörper), TP53 (zeige TP53 Antikörper) and THOP1.
THOP1 may have clinical potentials to be employed as a promising biomarker to identify individuals with better prognosis and a novel antitumor agent for therapy of patients with NSCLC
Low THOP1 expression levels are associated with recurrence of hepatocellular carcinoma.
TCEP. Data indicate that THIMET-oligopeptidase (TOP) oxidation by H2O2 and high valence states of hemeproteins does not lead to enzyme oligomerization.
The semi-quantitative intracellular peptidome analyses of siRNA-transfected HEK293 cells shows that the levels of specific intracellular peptides are either increased or decreased upon EP24.15 inhibition.
human thimet oligopeptidase crystal structure shows substrate recognition, regulation, and localization
EP24.15 associates with AT1 (zeige AGTR1 Antikörper) and B2 receptors both at the plasma membrane and after receptor internalization
Mutations at only two residues (Glu-469 and Arg-498) are required to swap specificity with neurolysin, a result that is confirmed by testing the two-mutant constructs.
increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta (zeige APP Antikörper) load.
Over 100 peptides were identified in human embryonic kidney 293 (HEK293) cells that are derived from intracellular proteins; many but not all of these peptides are substrates or products of EP24.15.
the cellular peptidases dipeptidyl peptidase 3 (DPP-3 (zeige DPP3 Antikörper)) and thimet oligopeptidase 1 (TOP-1 (zeige TOP1 Antikörper)), both of which are present in nonimmunogenic necrotic cells, eliminated proteasomal degradation products and blocked Ag cross-presentation
Data show that Thimet oligopeptidase (TOP) is coexpressed with estrogen receptor alpha (zeige ESR1 Antikörper), and estradiol regulates TOP expression in a brain region-specific manner in female mice.
EP24.15 association with lipid rafts on the extracellular surface precedes constitutive release of the peptidase into the extracellular milieu for its action on neuropeptides
Melanoma cells secrete thimet oligopeptidase which have an important role in tumor proliferation/angiogenesis in vitro and in vivo.
Cyclic strain putatively regulates both the mRNA expression and enzymatic function of EP24.15 and EP24.16 (zeige NLN Antikörper).
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
thimet oligopeptidase 1
, thimet oligopeptidase-like
, thimet oligopeptidase
, Thimet oligopeptidase
, endopeptidase 24.15
, endo-oligopeptidase A
, soluble metallo-endopeptidase
, endopeptidase EC22.214.171.124