anti-TIMP Metallopeptidase Inhibitor 2 (TIMP2) Antikörper

TIMP2 is a member of the TIMP gene family.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human TIMP2 TIMP2 7077 P16035
Anti-Ratte TIMP2 TIMP2 29543 P30121
Anti-Maus TIMP2 TIMP2 21858  
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Weitere Antikörper gegen TIMP Metallopeptidase Inhibitor 2 Interaktionspartner

Human TIMP Metallopeptidase Inhibitor 2 (TIMP2) Interaktionspartner

  1. High TIMP2 expression is associated with acute kidney injury.

  2. High TIMP2 expression is associated with acute kidney injury.

  3. expression of TIMP2 was inversely associated with miR (zeige MLXIP Antikörper)-106a in nodule tissues. Apoptotic body was also seen under electron microscope accompanied by silencing of miR (zeige MLXIP Antikörper)-106a. Together, this data indicated that miR (zeige MLXIP Antikörper)-106a may act as an oncogene (zeige RAB1A Antikörper) and contribute to gastric cancer development.

  4. Data show that the mean values for TIMP1 (zeige TIMP1 Antikörper), TIMP2 and MMP2 (zeige MMP2 Antikörper) were lower in survivors, MMP9 (zeige MMP9 Antikörper) was higher in survivors.

  5. Urine [TIMP-2]*[IGFBP7 (zeige IGFBP7 Antikörper)] is a promising candidate for early detection of AKI, especially in ruling-out AKI

  6. We conclude that in the resected esophageal cancer an increased mRNA expression of MMP-7 (zeige MMP7 Antikörper), MMP-10 (zeige MMP10 Antikörper) and TIMP-1 (zeige TIMP1 Antikörper) correlated with clinicopathologic features. We suggest that these genes may play a role during progression of the disease. MMP-10 (zeige MMP10 Antikörper), MMP-7 (zeige MMP7 Antikörper), TIMP-1 (zeige TIMP1 Antikörper), TIMP-2 were overexpressed in 73%, 85%, 55% and 42% of esophageal cancer samples, respectively.

  7. At hospital admission, all viral gastroenteritis (GE) patients viral gastroenteritis (GE) patients demonstrated increased MMP-9 (zeige MMP9 Antikörper) and decreased MMP-2 (zeige MMP2 Antikörper) and TIMP-2 serum levels; kinetics of serum MMP-2 (zeige MMP2 Antikörper), MMP-9 (zeige MMP9 Antikörper), and TIMP-2 levels were similar among the viral GE patients but distinct from bacterial enteritis patients; involvement of MMPs and TIMPs in the pathophysiology of gastrointestinal symptoms likely varies depending on the

  8. Meta-analysis indicated that urinary [TIMP-2].[IGFBP7 (zeige IGFBP7 Antikörper)] may be a reliable biomarker for the early detection of acute kidney injury in adults.

  9. Results show that resistant hypertension was associated with higher TIMP-2 levels and low MMP-2 (zeige MMP2 Antikörper)/TIMP-2 ratio, suggesting that these regulators of ECM (zeige MMRN1 Antikörper) remodeling play a key role in blood pressure control in this high-risk subset of hypertensive individuals.

  10. TIMP-2 is both expressed and secreted preferentially by cells of distal tubule origin, while IGFBP7 (zeige IGFBP7 Antikörper) is equally expressed across tubule cell types yet preferentially secreted by cells of proximal tubule origin. In human kidney tissue, strong staining of IGFBP7 (zeige IGFBP7 Antikörper) was seen in the luminal brush-border region of a subset of proximal tubule cells, and TIMP-2 stained intracellularly in distal tubules.

Cow (Bovine) TIMP Metallopeptidase Inhibitor 2 (TIMP2) Interaktionspartner

  1. Data indicate the involvement of PKC-alpha (zeige PKCa Antikörper) in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB (zeige NFKB1 Antikörper)-MT1-MMP (zeige MMP14 Antikörper)-dependent and -independent pathway.

  2. A differential pattern of matrix metalloproteinase-2 (zeige MMP2 Antikörper) and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.

  3. MMP-14 (zeige MMP14 Antikörper), MMP-2 (zeige MMP2 Antikörper) and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

  4. Results describe distinct changes in expression of MMP2 (zeige MMP2 Antikörper), MMP14 (zeige MMP14 Antikörper), and the metallopeptidase (zeige ECEL1 Antikörper) inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation.

  5. Production of TIMP-1 (zeige TIMP1 Antikörper) was augmented by IL-1alpha, TNFalpha (zeige TNF Antikörper), and hepatocyte growth factor (zeige HGF Antikörper) at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments.

  6. the different temporal expression patterns of TIMP-1 (zeige TIMP1 Antikörper) and TIMP-2 suggest that TIMP-1 (zeige TIMP1 Antikörper) may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance

  7. Identification, purification and partial characterization of timp-2 in bovine pulmonary artery smooth muscle

  8. Results describe the isolation of matrix metalloproteinase 2 (MMP-2 (zeige MMP2 Antikörper)) from the MMP-2 (zeige MMP2 Antikörper)/tissue inhibitor of metalloproteinase 2 (TIMP-2) complex, and the characterization of both isolated MMP-2 (zeige MMP2 Antikörper) and the complex itself.

  9. oxidants inactivate TIMP-2, and the resulting activation of MMP-2 (zeige MMP2 Antikörper) subsequently inhibits Na+ dependent Ca2 (zeige CA2 Antikörper)+ uptake in the microsomes

  10. TIMP-2 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.

Mouse (Murine) TIMP Metallopeptidase Inhibitor 2 (TIMP2) Interaktionspartner

  1. the protein expression levels of TIMP-2 and PBEF (zeige NAMPT Antikörper) in cloned placentae, were examined.

  2. demonstrate that TIMP-2 plays a greater protective role than TIMP-1 (zeige TIMP1 Antikörper) during the pathogenesis of atherosclerosis

  3. Further investigation of MMP2 (zeige MMP2 Antikörper) inhibitors of TIMP2/TIMP4 (zeige TIMP4 Antikörper) showed an upregulated TIMP2 expression, but not TIMP4 (zeige TIMP4 Antikörper). low-dose pre-radiation attenuates the skin inflammation and ROS (zeige ROS1 Antikörper) production induced by medium-dose UV radiation

  4. TIMP2 and TIMP3 (zeige TIMP3 Antikörper) play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function

  5. Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK (zeige MAPK14 Antikörper) signaling pathway.

  6. High TIMP2 expression is associated with liver fibrosis.

  7. TIMP2 promotes kidney injury through metalloproteinase (MMP)2 (zeige MMP2 Antikörper) activation

  8. Gene expression of Mmp-12 (zeige MMP12 Antikörper) and Mmp-13 (zeige MMP13 Antikörper), and Timp-1 (zeige TIMP1 Antikörper) was strongly upregulated at all time points in RD compared with controls. Timp-2, Mmp-2 (zeige MMP2 Antikörper), and Mmp-9 (zeige MMP9 Antikörper) expression was modest.

  9. Data indicate a significantly increased expression of type I collagen, TIMP-2, TGF-beta (zeige TGFB1 Antikörper), PAI-1 (zeige SERPINE1 Antikörper) and RAGE (zeige AGER Antikörper) in diabetic db/db (zeige LEPR Antikörper) cells.

  10. This study suggests that miR-17 participates in the regulation of cardiac matrix remodeling and provides a novel therapeutic approach using miR-17 inhibitors to prevent remodeling and heart failure after MI.

Xenopus laevis TIMP Metallopeptidase Inhibitor 2 (TIMP2) Interaktionspartner

  1. overexpression of TIMP-2 N- and C-terminal domains results in severe developmental defects and death, as well as unique changes in MMP-2 (zeige MMP2 Antikörper) and -9 expression, indicating that the individual domains may regulate MMPs through distinct mechanisms

  2. characterization of Xenopus tissue inhibitor of metalloproteinases-2

TIMP Metallopeptidase Inhibitor 2 (TIMP2) Antigen-Profil

Protein Überblick

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Genbezeichner und Symbole assoziert mit TIMP2

  • TIMP metallopeptidase inhibitor 2 (TIMP2) Antikörper
  • TIMP metallopeptidase inhibitor 2 (Timp2) Antikörper
  • tissue inhibitor of metalloproteinase 2 (Timp2) Antikörper
  • TIMP metallopeptidase inhibitor 2 (timp2) Antikörper
  • tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) Antikörper
  • Metalloproteinase inhibitor 2 (timp2) Antikörper
  • CSC-21K Antikörper
  • D11Bwg1104e Antikörper
  • DDC8 Antikörper
  • MGC84288 Antikörper
  • MGC108274 Antikörper
  • TIMP-2 Antikörper
  • timp2 Antikörper

Bezeichner auf Proteinebene für TIMP2

TIMP-2 , metalloproteinase inhibitor 2 , tissue inhibitor of metalloproteinase 2 , tissue inhibitor of metalloproteinases 2 , tissue inhibitor of matrix metalloproteinase-2 , tissue inhibitor of metalloproteinase-2 , collagenase inhibitor , tissue inhibitor of mettaloproteinase 2 , TIMP metallopeptidase inhibitor 2 , Metalloproteinase inhibitor 2

GENE ID SPEZIES
7077 Homo sapiens
29543 Rattus norvegicus
374178 Gallus gallus
403633 Canis lupus familiaris
282093 Bos taurus
21858 Mus musculus
447572 Xenopus laevis
548477 Xenopus (Silurana) tropicalis
574357 Macaca mulatta
100196250 Salmo salar
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