TIMELESS Interacting Protein Proteine (TIPIN)

Required for normal progression of S-phase. Zusätzlich bieten wir Ihnen TIPIN Antikörper (72) und TIPIN Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TIPIN 100359731  
TIPIN 54962 Q9BVW5
TIPIN 66131 Q91WA1
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Top TIPIN Proteine auf antikoerper-online.de

Showing 10 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
218,90 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.592,86 €
Details
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.613,81 €
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.633,02 €
Details
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.840,79 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
379,93 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 5 bis 7 Tage
324,01 €
Details

TIPIN Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Rat (Rattus)

Human ,
,
Mouse (Murine)

Weitere Proteine zu TIMELESS Interacting Protein (TIPIN) Interaktionspartnern

Xenopus laevis TIMELESS Interacting Protein (TIPIN) Interaktionspartner

  1. Mta2 (zeige MTA2 Proteine) and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate.

  2. data indicate that Tipin/Tim1/And1 (zeige WDHD1 Proteine) form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion

Human TIMELESS Interacting Protein (TIPIN) Interaktionspartner

  1. the 1.85 A crystal structure of a large N-terminal segment of human Timeless, spanning amino acids 1-463, is presented and this region of human Timeless harbours a partial binding site for Tipin.

  2. TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer.

  3. Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer (zeige MERTK Proteine) DNA ligand.

  4. Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins.

  5. We now show that cellular DNA replication fork pausing and protection factors Timeless (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle.

  6. RPA (zeige RPA1 Proteine)-covered ssDNA not only supports recruitment and activation of ATR (zeige ANTXR1 Proteine) but also, through Tipin and Claspin, it plays an important role in the action of ATR (zeige ANTXR1 Proteine) on its critical downstream target Chk1 (zeige CHEK1 Proteine)

  7. The results suggest that Timeless-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks.

  8. Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin in response to replication checkpoint

  9. observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless-depleted cells

  10. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.

Mouse (Murine) TIMELESS Interacting Protein (TIPIN) Interaktionspartner

  1. mTIM promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes

  2. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.

  3. The tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 (zeige CHEK1 Proteine) pathway for continued DNA synthesis.

TIPIN Protein Überblick

Protein Überblick

Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be required in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).

Genbezeichner und Symbole assoziert mit TIPIN

  • timeless interacting protein (tipin)
  • TIMELESS interacting protein (TIPIN)
  • timeless interacting protein (LOC100359731)
  • timeless interacting protein (Tipin)
  • XTimeless interacting protein (xtipin)
  • 1110005A05Rik Protein
  • 1110018P21Rik Protein
  • MGC82649 Protein
  • RGD1564084 Protein
  • tipin Protein
  • zgc:91928 Protein

Bezeichner auf Proteinebene für TIPIN

timeless interacting protein , TIMELESS interacting protein , timeless-interacting protein , TIMELESS-interacting protein , CSM3 homolog , mitotic phosphoprotein 67

GENE ID SPEZIES
444047 Xenopus laevis
453525 Pan troglodytes
100126681 Xenopus (Silurana) tropicalis
100359731 Rattus norvegicus
445058 Danio rerio
415548 Gallus gallus
54962 Homo sapiens
100683743 Canis lupus familiaris
506176 Bos taurus
66131 Mus musculus
363076 Rattus norvegicus
394376 Xenopus laevis
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