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THO Complex 1 Proteine (THOC1)

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010].. Zusätzlich bieten wir Ihnen THOC1 Antikörper (83) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
THOC1 9984 Q96FV9
THOC1 225160 Q8R3N6
THOC1 291797  
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.790,16 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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THOC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu THO Complex 1 (THOC1) Interaktionspartnern

Human THO Complex 1 (THOC1) Interaktionspartner

  1. Colorectal cancer patients with high levels of Thoc1 expression had poorer overall-survival and disease-free survival, whereas those with lower levels of Thoc1 expression survived longer.

  2. In humans, high THOC1 protein expression associates with prostate cancer aggressiveness and recurrence. Thus, THOC1 protein is a molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment.

  3. Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells.

  4. This suggests NEDD4-1 (zeige NEDD4 Proteine) functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO (zeige THOC2 Proteine) activity.

  5. overexpression of hTREX84 is associated with cancer cell transformation, proliferation and may be regulated by RelA/p65 (zeige NFkBP65 Proteine)

  6. We show that human THO (zeige THOC2 Proteine) depletion impairs transcription elongation and mRNA export and increases instability associated with DNA breaks, leading to hyper-recombination and gammaH2AX (zeige H2AFX Proteine) and 53BP1 (zeige TP53BP1 Proteine) foci accumulation

  7. A differential connection between tumorogenesis and the expression levels of human THO (zeige THOC2 Proteine) and ALY (zeige THOC4 Proteine).

  8. hHpr1/p84/Thoc1 regulates transcriptional elongation and may participate in a protein complex functionally analogous to yeast TREX, physically linking elongating RNA polymerase II with RNA processing factors

  9. Thoc1 may be important for neoplastic transformation

  10. Cells respond to AAV infection by activating two DNA damage signaling cascades. The first activates the p84N5 protein, which in turn activates caspase-6 (zeige CASP6 Proteine), leading to cell death.

Mouse (Murine) THO Complex 1 (THOC1) Interaktionspartner

  1. Results found that Thoc1 deficiency delays embryo death, and suggest that Thoc1 is required to support increased expression of E2f (zeige E2F1 Proteine) and apoptotic regulatory genes that trigger apoptosis upon Rb1 (zeige RB1 Proteine) loss.

  2. granulocyte macrophage progenitors have a cell autonomous requirement for Thoc1 to maintain cell growth and viability

  3. Thoc1 gene deletion prevents prostate cancer progression in mice, but has little effect on normal tissue. Prostate cancer cells deprived of Thoc1 show gene expression defects that compromise cell growth.

  4. Thoc1 loss compromises the proliferation and lineage-generating capacity of small intestinal stem cells, disrupting the supply of differentiated cells in this rapidly renewing tissue.

  5. This suggests NEDD4-1 (zeige NEDD4 Proteine) functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO (zeige THOC2 Proteine) activity.

  6. results demonstrate that NO-mediated thoc1 downregulation, via Nrf2, is a key step in the cancer cell apoptosis induced by CCL-34-treated macrophages

  7. THOC5/Fms interacting protein (zeige THOC5 Proteine) is an essential element in the maintenance of hematopoiesis, and depletion of THOC5/Fms interacting protein (zeige THOC5 Proteine) causes the down-regulation of THOC1, which may contribute to altered THO (zeige THOC2 Proteine) complex function and cell death

  8. The generation and phenotypic characterization of mice containing a null allele of the Thoc1 gene is described.

  9. These findings support the notion that Thoc1-mediated RNP (zeige RNPC3 Proteine) assembly contributes to the coordinated expression of genes necessary for normal differentiation and development in vivo.

THOC1 Protein Überblick

Protein Überblick

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).

Genbezeichner und Symbole assoziert mit THO Complex 1 Proteine (THOC1)

  • THO complex 1 (thoc1)
  • THO complex 1 (THOC1)
  • THO complex 1 (Thoc1)
  • THO complex 1 protein (thoc1)
  • 3110002N20Rik Protein
  • AW107452 Protein
  • HPR1 Protein
  • LRRGT00070 Protein
  • MGC114861 Protein
  • NMP-84 Protein
  • P84 Protein
  • P84N5 Protein
  • Tho1 Protein
  • THOC1 Protein

Bezeichner auf Proteinebene für THO Complex 1 Proteine (THOC1)

THO complex subunit 1 , THO complex 1 , nuclear matrix protein p84 , THO complex subunit 1-like , THO complex 1 protein , hTREX84 , tho1

GENE ID SPEZIES
373077 Danio rerio
398505 Xenopus laevis
421062 Gallus gallus
455324 Pan troglodytes
697954 Macaca mulatta
100051155 Equus caballus
100123388 Nasonia vitripennis
100393939 Callithrix jacchus
100473279 Ailuropoda melanoleuca
100580031 Nomascus leucogenys
100625217 Sus scrofa
733546 Xenopus (Silurana) tropicalis
9984 Homo sapiens
225160 Mus musculus
291797 Rattus norvegicus
490529 Canis lupus familiaris
100138748 Bos taurus
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