T Cell Immunoreceptor with Ig and ITIM Domains Proteine (TIGIT)

TIGIT encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. Zusätzlich bieten wir Ihnen TIGIT Antikörper (50) und TIGIT Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TIGIT 201633 Q495A1
TIGIT 100043314  
TIGIT 363784  
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Top TIGIT Proteine auf antikoerper-online.de

Showing 10 out of 38 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Maus His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
Details
HOST_Human Cells Human His tag 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
650,00 €
Details
HOST_HEK-293 Cells Human Fc Tag Human TIGIT, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. Measured by its binding ability in a functional ELISA. Immobilized Human TIGIT, Fc Tag  with a linear range of 5-78 ng/mL. 50 μg Anmelden zum Anzeigen 25 bis 36 Tage
428,57 €
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
Details
HOST_HEK-293 Cells Cynomolgus Fc Tag Cynomolgus TIGIT, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Human CD155, His Tag (Cat# CD5-H5223) at 10 μg/mL (100 μl/well) can bind Cynomolgus TIGIT, Fc Tag (Cat# TIT-C5254) with a linear range of 0.2-20 μg/mL. 50 μg Anmelden zum Anzeigen 9 bis 10 Tage
428,57 €
Details
HOST_HEK-293 Cells Human AVI tag,Biotin,His tag Biotinylated Human TIGIT, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Human CD112, Fc Tag (Cat# PV2-H5253) at 10 μg/mL (100 μL/well) can bind Biotinylated Human TIGIT, His Tag  with a linear range of 0.6-5 μg/mL. 200 μg Anmelden zum Anzeigen 9 bis 10 Tage
1.605,71 €
Details
HOST_HEK-293 Cells Kaninchen Fc Tag Rabbit TIGIT, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Anmelden zum Anzeigen 9 bis 10 Tage
428,57 €
Details

TIGIT Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , ,
, , , , , , ,
Mouse (Murine) , , , , ,
, , ,
Rat (Rattus) ,
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Am meisten referenzierte TIGIT Proteine

  1. Human TIGIT Protein expressed in HEK-293 Cells - ABIN2181816 : Yu, Harden, Gonzalez, Francesco, Chiang, Irving, Tom, Ivelja, Refino, Clark, Eaton, Grogan: The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. in Nature immunology 2008 (PubMed)
    Zeige alle 3 Referenzen für 2181816

  2. Mouse (Murine) TIGIT Protein expressed in Human Cells - ABIN2008430 : Stanietsky, Simic, Arapovic, Toporik, Levy, Novik, Levine, Beiman, Dassa, Achdout, Stern-Ginossar, Tsukerman, Jonjic, Mandelboim: The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)

Weitere Proteine zu T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Interaktionspartnern

Human T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Interaktionspartner

  1. TIGIT is a powerful negative regulator of CD4 (zeige CD4 Proteine)(+) T cells in systemic lupus erythematosus.

  2. TIGIT signaling in NK cells after MDSC coculture led to a decrease in the phosphorylation of ZAP70/Syk and ERK1/2.

  3. energetic basis for the TIGIT/nectin-2 (zeige PVRL2 Proteine) interaction and revealed that an "aromatic key" of nectin-2 (zeige PVRL2 Proteine) is critical for this interaction, whereas variations in the lock were tolerated.

  4. TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization.

  5. implying that TIGIT exerts immunosuppressive effects by competing with DNAM-1 (zeige CD226 Proteine) for the same ligand, CD155 (zeige PVR Proteine)

  6. These findings identify TIGIT as a novel marker of dysfunctional HIV-specific T cells

  7. This study shows that HBZ (zeige HBZ Proteine)-induced TIGIT plays a pivotal role in attenuating host immune responses and shaping a microenvironment favorable to human T-cell leukemia virus type 1.

  8. a novel mechanism that links TIGIT expression with NK-cell functional heterogeneity, and this mechanism might partially explain why individuals have different susceptibilities to infection, autoimmune disease, and cancer.

  9. Human regulatory T cells expressing the receptors TIGIT and CD226 (zeige CD226 Proteine) display widely divergent phenotypes in regard to expansion and activation.

  10. TIGIT and PD-1 (zeige PDCD1 Proteine) blockade additively increased proliferation, cytokine production, and degranulation of tumor-antigen-specific CD8 (zeige CD8A Proteine) T cells and CD8 (zeige CD8A Proteine) TILs. TIGIT and PD-1 (zeige PDCD1 Proteine) regulate the expansion and function of these T cells in melanoma.

Mouse (Murine) T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Interaktionspartner

  1. TIGIT is a powerful negative regulator of CD4 (zeige CD4 Proteine)(+) T cells in systemic lupus erythematosus.

  2. study provides evidence that TIGIT expression by Th cells and its interaction with CD155 (zeige PVR Proteine) enhances Th2 responses, and blockade of TIGIT is therapeutic for experimental allergic airway inflammation

  3. TIGIT negatively regulates inflammation by altering macrophage phenotype.

  4. TIGIT signaling in Tregs directs their phenotype. It suppresses antitumor immunity via Tregs and not CD8 (zeige CD8A Proteine)+ T cells. TIGIT+ Tregs upregulated TIM-3 (zeige HAVCR2 Proteine) expression in tumor tissue. TIM-3 (zeige HAVCR2 Proteine) and TIGIT synergized to suppress antitumor immune responses.

  5. TIGIT is a safeguard molecule to improve liver regeneration through negatively regulating NK-hepatocyte crosstalk.

  6. Findings suggest that TIGIT is a key checkpoint inhibitor of chronic antiviral and antitumor responses through impairing CD226 (zeige CD226 Proteine) function when disrupting its homodimerization.

  7. TIGIT/PVR (zeige PVRL2 Proteine) ligation signaling mediates suppression of IFN-gamma (zeige IFNG Proteine) production via the NF-kappaB (zeige NFKB1 Proteine) pathway.

  8. expressed on a Treg cell subset that selectively suppresses Th1 (zeige HAND1 Proteine) and Th17 cells but not Th2 cells

  9. found that TIGIT was up-regulated selectively on NK cells and protected against liver injury in an acute adenovirus infection model in both an NK cell- and Kupffer cell-dependent manner

  10. findings show that TIGIT is expressed by NK cells, that it interacts specifically with PVR (zeige PVRL2 Proteine) and possibly with an additional unknown ligand found on PBMCs and that these interactions lead to the inhibition of NK-cell activities

TIGIT Protein Überblick

Protein Überblick

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity\; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.

Genbezeichner und Symbole assoziert mit TIGIT

  • T cell immunoreceptor with Ig and ITIM domains (TIGIT)
  • T cell immunoreceptor with Ig and ITIM domains (Tigit)
  • ENSMUSG00000071552 Protein
  • RGD1563191 Protein
  • VSIG9 Protein
  • Vstm3 Protein
  • WUCAM Protein

Bezeichner auf Proteinebene für TIGIT

T-cell immunoreceptor with Ig and ITIM domains , V-set and immunoglobulin domain containing 9 , V-set and immunoglobulin domain-containing protein 9 , V-set and transmembrane domain containing 3 , V-set and transmembrane domain-containing protein 3 , Washington University cell adhesion molecule

GENE ID SPEZIES
201633 Homo sapiens
100043314 Mus musculus
363784 Rattus norvegicus
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