Synuclein, alpha Interacting Protein Proteine (SNCAIP)

SNCAIP encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. Zusätzlich bieten wir Ihnen SNCAIP Antikörper (60) und SNCAIP Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SNCAIP 9627 Q9Y6H5
SNCAIP 307309  
SNCAIP 67847  
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Top SNCAIP Proteine auf antikoerper-online.de

Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$608.00
Details

SNCAIP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Rat (Rattus)
Mouse (Murine)

Weitere Proteine zu Synuclein, alpha Interacting Protein (SNCAIP) Interaktionspartnern

Human Synuclein, alpha Interacting Protein (SNCAIP) Interaktionspartner

  1. Differential expression of synphilin-1 isoforms (and alpha-synuclein and parkin (zeige PARK2 Proteine)) was found in multiple system atrophy brains compared to control brain.

  2. Synphilin-1 binds ATP, but not CTP (zeige CDS1 Proteine).

  3. Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.

  4. Overexpression of SP1 (zeige PSG1 Proteine) in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 (zeige PSG1 Proteine) increased food intake but did not affect locomotor activity

  5. Although serine-129 phosphorylation of alpha-synuclein facilitates tubulin polymerization promoting protein (TPPP (zeige Tppp Proteine))-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.

  6. Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.

  7. Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation.

  8. Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.

  9. Knockdown of Herp (zeige HERPUD1 Proteine) gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.

  10. Data show that periphilin (zeige PPHLN1 Proteine) displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin (zeige PPHLN1 Proteine) in PD.

Mouse (Murine) Synuclein, alpha Interacting Protein (SNCAIP) Interaktionspartner

  1. This study shows that alpha-synuclein is present in cerebellar glutamatergic terminals.

  2. These results suggest that increased levels of NUB1 play a potential role in degradation of detergent-insoluble alpha-synuclein in vivo, although it is insufficient to degrade abnormal alpha-synuclein in Lewy body disease model mice.

  3. SP1 (zeige SP1 Proteine) results in a CCK (zeige CCK Proteine) response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice

  4. TEM analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein, suggesting the therapeutic potential of the small molecule in PD.

  5. We exploited atomic force microscopy (AFM) for the selective, nanoscale confinement of alpha-Synuclein on gold to study the early stages of alpha-Synuclein aggregation and the effect of small molecules, like dopamine, on the aggregation process.

  6. Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments.

  7. Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics.

  8. Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein toxicity in vivo.

  9. synphilin-1 has a role in skill learning and motor performance

  10. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease

SNCAIP Protein Überblick

Protein Überblick

This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined.

Genbezeichner und Symbole assoziert mit SNCAIP

  • synuclein alpha interacting protein (SNCAIP)
  • synuclein alpha interacting protein (sncaip)
  • synuclein, alpha interacting protein (Sncaip)
  • synuclein alpha interacting protein (Sncaip)
  • synuclein, alpha interacting protein (synphilin) (Sncaip)
  • 2810407O15Rik Protein
  • 4933427B05Rik Protein
  • BB104594 Protein
  • LOC100221074 Protein
  • MGC88953 Protein
  • SNCAIP Protein
  • Sph1 Protein
  • Syph1 Protein

Bezeichner auf Proteinebene für SNCAIP

synuclein, alpha interacting protein , synuclein, alpha interacting protein (synphilin) , synphilin-1-like , alpha-synuclein-interacting protein , synphilin-1 , synuclein alpha interacting protein , synphilin-1 variant 1e

GENE ID SPEZIES
100063985 Equus caballus
448237 Xenopus (Silurana) tropicalis
700372 Macaca mulatta
462021 Pan troglodytes
100406168 Callithrix jacchus
100481199 Ailuropoda melanoleuca
100559476 Anolis carolinensis
100221074 Taeniopygia guttata
9627 Homo sapiens
307309 Rattus norvegicus
426796 Gallus gallus
100720184 Cavia porcellus
67847 Mus musculus
481479 Canis lupus familiaris
100049698 Sus scrofa
540156 Bos taurus
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