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SNCAIP encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. Zusätzlich bieten wir Ihnen SNCAIP Proteine (6) und SNCAIP Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SNCAIP Primary Antibody für IF, IHC (p) - ABIN2476664
Büttner, Delay, Franssens, Bammens, Ruli, Zaunschirm, de Oliveira, Outeiro, Madeo, Buée, Galas, Winderickx: Synphilin-1 enhances ?-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. in PLoS ONE 2010
Differential expression of synphilin-1 isoforms (and alpha-synuclein (zeige SNCA Antikörper) and parkin (zeige PARK2 Antikörper)) was found in multiple system atrophy brains compared to control brain.
Synphilin-1 binds ATP, but not CTP (zeige CDS1 Antikörper).
Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.
Overexpression of SP1 (zeige PSG1 Antikörper) in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 (zeige PSG1 Antikörper) increased food intake but did not affect locomotor activity
Although serine-129 phosphorylation of alpha-synuclein (zeige SNCA Antikörper) facilitates tubulin polymerization promoting protein (TPPP (zeige Tppp Antikörper))-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.
Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.
Neuronal survival factor MEF2D (zeige MEF2D Antikörper) is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein (zeige SNCA Antikörper) accumulation and aggregation.
Synphilin-1 inhibits alpha-synuclein (zeige SNCA Antikörper) degradation by the proteasome.
Knockdown of Herp (zeige HERPUD1 Antikörper) gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.
Data show that periphilin (zeige PPHLN1 Antikörper) displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin (zeige PPHLN1 Antikörper) in PD.
This study shows that alpha-synuclein (zeige SNCA Antikörper) is present in cerebellar glutamatergic terminals.
These results suggest that increased levels of NUB1 (zeige NPM3 Antikörper) play a potential role in degradation of detergent-insoluble alpha-synuclein (zeige SNCA Antikörper) in vivo, although it is insufficient to degrade abnormal alpha-synuclein (zeige SNCA Antikörper) in Lewy body disease model mice.
SP1 (zeige SP1 Antikörper) results in a CCK (zeige CCK Antikörper) response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice
TEM (zeige TNMD Antikörper) analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein (zeige SNCA Antikörper), suggesting the therapeutic potential of the small molecule in PD.
We exploited atomic force microscopy (AFM (zeige AFM Antikörper)) for the selective, nanoscale confinement of alpha-Synuclein (zeige SNCA Antikörper) on gold to study the early stages of alpha-Synuclein (zeige SNCA Antikörper) aggregation and the effect of small molecules, like dopamine, on the aggregation process.
Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments.
Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics.
Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein (zeige SNCA Antikörper) toxicity in vivo.
synphilin-1 has a role in skill learning and motor performance
expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined.
synuclein, alpha interacting protein
, synuclein, alpha interacting protein (synphilin)
, alpha-synuclein-interacting protein
, synuclein alpha interacting protein
, synphilin-1 variant 1e