Syntaxin Binding Protein 5 (Tomosyn) Proteine (STXBP5)

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. Zusätzlich bieten wir Ihnen STXBP5 Antikörper (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
STXBP5 134957 Q5T5C0
STXBP5 78808  
Ratte STXBP5 STXBP5 81022 Q9WU70
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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STXBP5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) Interaktionspartnern

Human Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) Interaktionspartner

  1. Using CRISPR/Cas9 genome editing, identified a human nonsynonymous SNP rs1039084 in the STXBP5 locus as a causal variant for a decreased thrombotic phenotype.

  2. Genetic variations in STXBP5 and CLEC4M (zeige CLEC4M Proteine) are associated with VWF (zeige VWF Proteine) level variation in type 1, but not in type 2 von Willebrand disease.

  3. STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion

  4. STXBP5 inhibits endothelial exocytosis and promotes platelet secretion

  5. Identify 3 loci associated with circulating tPA (zeige PLAT Proteine) levels, the PLAT (zeige PLAT Proteine) region, STXBP5, and STX2 (zeige STX2 Proteine). Functional studies implicate a novel role for STXBP5 and STX2 (zeige STX2 Proteine) in regulating tPA (zeige PLAT Proteine) release.

  6. Genetic variation in STXBP5 is associated with bleeding phenotype in female type 1 von Willebrand Disease patients.

  7. Genetic variation in STXBP5 gene is associated with venous thrombosis.

  8. multiple domains outside the R-SNARE (zeige YKT6 Proteine) of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion

  9. Genetic variability in STXBP5 and STX2 (zeige STX2 Proteine) affects both VWF (zeige VWF Proteine) concentration and activity in young individuals with premature arterial thrombosis.

Mouse (Murine) Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) Interaktionspartner

  1. Data indicate that bidirectional moving tomosyn-1 (Stxbp5) and tomosyn-2 (Stxbp5l) puncta were observed.

  2. Mouse Embryonic Stem (mES (zeige PTCH1 Proteine)) cells self-differentiated into arginine vasopressin (AVP (zeige AVP Proteine)) neurons (mES (zeige PTCH1 Proteine)-AVP (zeige AVP Proteine)) that expressed tomosyn and two transmembrane SNARE (zeige VTI1B Proteine) proteins, including SNAP25 (zeige SNAP25 Proteine) and syntaxin1 (zeige STX1A Proteine). Tomosyn negatively regulates arginine vasopressin (zeige AVP Proteine) secretion in embryonic stem cell-derived neurons.

  3. PIASgamma-dependent modification of tomosyn-1 with SUMO-2 (zeige SUMO2 Proteine)/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment.

  4. STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion

  5. STXBP5 inhibits endothelial exocytosis and promotes platelet secretion

  6. regulates SNARE (zeige VTI1B Proteine) complex formation and synaptic vesicle fusion. (review)

  7. Interacts with SNAP23 (zeige SNAP23 Proteine) and Syntaxin4 (zeige STX4 Proteine) and plays a role in Insulin (zeige INS Proteine)-stimulated GLUT4 (zeige SLC2A4 Proteine) translocacion.

  8. The interaction between syntaxin4 (zeige STX4 Proteine) and Munc18c (zeige STXBP3 Proteine) in adipocytes results in enhancement of insulin (zeige INS Proteine)-stimulated GLUT4 (zeige SLC2A4 Proteine) externalization.

  9. In the pancreatic beta-cell, tomosyn negatively regulates insulin (zeige INS Proteine) exocytosis.

  10. Tomosyn-1 is involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin (zeige INS Proteine) secretagogues.

STXBP5 Protein Überblick

Protein Überblick

Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Genbezeichner und Symbole assoziert mit STXBP5

  • syntaxin binding protein 5 (tomosyn) (STXBP5)
  • syntaxin binding protein 5 (tomosyn) (Stxbp5)
  • 0710001E20Rik Protein
  • 4930565N16Rik Protein
  • AW742610 Protein
  • LGL3 Protein
  • LLGL3 Protein
  • mKIAA1006 Protein
  • Nbla04300 Protein

Bezeichner auf Proteinebene für STXBP5

lethal(2) giant larvae protein homolog 3 , putative protein product of Nbla04300 , syntaxin-binding protein 5 , tomosyn , tomosyn-1 , tomosyn 1

GENE ID SPEZIES
134957 Homo sapiens
78808 Mus musculus
81022 Rattus norvegicus
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