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The product of STX2 belongs to the syntaxin/epimorphin family of proteins. Zusätzlich bieten wir Ihnen Syntaxin 2 Antikörper (70) und Syntaxin 2 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
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TGF-beta (zeige TGFB1 Proteine), bFGF (zeige FGF2 Proteine) and epimorphin in the extracellular microenvironment cooperatively affect HSF (zeige HSF1 Proteine) behaviors under the control of a highly sulfated (zeige SULF1 Proteine) chondroitin sulfate
The effects of HIV/HCV co-infection on hepatic fibrosis might be mediated in part by epimorphin (EPM). Strategies to limit the expression of EPM might represent a novel therapeutic approach to prevent the progression of hepatic fibrosis during HIV/HCV co-infection.
Identify 3 loci associated with circulating tPA (zeige PLAT Proteine) levels, the PLAT (zeige PLAT Proteine) region, STXBP5 (zeige STXBP5 Proteine), and STX2. Functional studies implicate a novel role for STXBP5 (zeige STXBP5 Proteine) and STX2 in regulating tPA (zeige PLAT Proteine) release.
Epimorphin can revert ovarian cancer cells away from their mesenchymal phenotype and toward an epithelial phenotype.
epimorphin modulates the signaling pathways mediated by EGFR (zeige EGFR Proteine) for epidermal tissue organization
Genetic variation in STX2 is associated with von Willebrand factor:Ag levels in patients diagnosed with type 1 von Willebrand Disease.
EPM, secreted by activated stellate cells within stroma, promotes invasion and metastasis of hepatocellular cancer cells by activating MMP-9 (zeige MMP9 Proteine) expression through the FAK (zeige PTK2 Proteine)-ERK (zeige EPHB2 Proteine) pathway.
Genetic variability in STXBP5 (zeige STXBP5 Proteine) and STX2 affects both VWF (zeige VWF Proteine) concentration and activity in young individuals with premature arterial thrombosis.
Munc18b (zeige STXBP2 Proteine) binds to syntaxins 1A, 2, and 3 and regulates vesicle transport to the apical plasma membrane
These findings suggest that epimorphin contributes to repair of pulmonary fibrosis in nonspecific interstitial pneumonia, perhaps partly by inducing expression of matrix metalloproteinase 2 (zeige MMP2 Proteine), which is an important proteolytic factor in lung remodeling.
Syn-2 knockout mice exhibited paradoxical superior glucose homeostasis resulting from an enhanced insulin (zeige INS Proteine) secretion. The increase in insulin (zeige INS Proteine) exocytosis was attributed mainly to an enhanced recruitment of the larger pool of newcomer secretory granules (SGs (zeige SKI Proteine)) that undergoes no residence time on plasma membrane before fusion and, to a lesser extent, also the predocked SGs (zeige SKI Proteine).
The selectivity in syntaxin binding and apical protein redistribution further suggests that rab17 (zeige RAB17 Proteine) and syntaxin 2 mediate fusion of transcytotic vesicles at the apical surface.
It was concluded that Epim deletion inhibits polyposis in Apcmin/+ mice, associated with increased mucosal TGF-beta (zeige TGFB1 Proteine) signaling and decreased myofibroblast HGF (zeige HGF Proteine) expression and secretion.
Overexpression of Epim expression is associated with mammary carcinoma.
These results suggest that STX2 plays roles in transport and/or subcellular distribution of sulfoglycolipids.
Epimorphin regulates bile duct formation via effects on mitosis orientation
Epimorphin has a pivotal role in the repair of renal fibrosis by modulating both extracellular matrix (ECM (zeige MMRN1 Proteine)) degradation and its production.
syntaxin 2 enters the membrane of a fused zymogen granule after the opening of the fusion pore
Epimorphin is involved in tissue repair following a single injection of carbon tetrachloride, in which distribution and the quantity of epimorphin expression are important, particularly in maintaining hepatocyte function.
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.
, Syntaxin 2
, syntaxin 1B2