Synovial Sarcoma, X Breakpoint 2 Proteine (SSX2)

The product of SSX2 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. Zusätzlich bieten wir Ihnen Synovial Sarcoma, X Breakpoint 2 Antikörper (62) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SSX2 6757 Q16385
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Showing 4 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Anmelden zum Anzeigen 15 bis 16 Tage
324,76 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   20 μg Anmelden zum Anzeigen 6 bis 8 Tage
379,93 €
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SSX2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Am meisten referenzierte Synovial Sarcoma, X Breakpoint 2 Proteine

  1. Human SSX2 Protein expressed in Wheat germ - ABIN1321452 : Smith, Cronk, Lang, McNeel: Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer. in Cancer research 2011 (PubMed)

Weitere Proteine zu Synovial Sarcoma, X Breakpoint 2 (SSX2) Interaktionspartnern

Human Synovial Sarcoma, X Breakpoint 2 (SSX2) Interaktionspartner

  1. Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18 (zeige SS18 Proteine)-SSX2 tumors. Re-analysis of human SS18 (zeige SS18 Proteine)-SSX1 (zeige SSX1 Proteine) and SS18 (zeige SS18 Proteine)-SSX2 tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 expression in SS18 (zeige SS18 Proteine)-SSX1 (zeige SSX1 Proteine) tumors.

  2. results reveal two important phenotypes of ectopic SSX2 expression that may drive/support tumorigenesis: First, immediate induction of genomic instability, and second, long-term support of tumor cell growth.

  3. The tumor-specific pattern of expression of SSX2.

  4. primary autoantibodies against intracellular MM-specific tumor antigens SSX-2 and NY-ESO-1 (zeige CTAG1B Proteine) are rare but functional in multiple myeloma patients after allogeneic stem cell transplantation

  5. SS18 (zeige SS18 Proteine)-SSX-induced Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression.

  6. SSX2, SSX3, and SSX4 are expressed in the lung tissue of only 3.5% early-stage non-small cell lung cancer patients.

  7. These results suggest that the characteristic speckle localization pattern of SS18 (zeige SS18 Proteine)-SSX is strongly involved in the tumorigenesis through the SSX moiety of the SS18 (zeige SS18 Proteine)-SSX fusion protein.

  8. the initial events that likely occur when SYT (zeige SS18 Proteine)-SSX2 is first expressed, and its dominant function in subverting the nuclear program of the stem cell, leading to its aberrant differentiation, as a first step toward transformation

  9. The regulation of estrogen receptor alpha (zeige ESR1 Proteine) signaling by target proteins of SSX2 may explain the metastatic potential of breast cancer cells.

  10. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase (zeige RAB40C Proteine) interactor, RABIN3, and a novel nuclear protein (zeige RDBP Proteine), SSX2IP (zeige SSX2IP Proteine).

Synovial Sarcoma, X Breakpoint 2 (SSX2) Protein Überblick

Protein Überblick

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X\\\\;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.

Genbezeichner und Symbole assoziert mit SSX2

  • synovial sarcoma, X breakpoint 2 (SSX2)
  • synovial sarcoma, X breakpoint 2B (SSX2B)
  • CT5.2 Protein
  • CT5.2A Protein
  • CT5.2b Protein
  • HD21 Protein
  • HOM-MEL-40 Protein
  • SSX Protein
  • SSX2 Protein
  • SSX3 Protein

Bezeichner auf Proteinebene für SSX2

cancer/testis antigen 5.2 , cancer/testis antigen family 5, member 2a , protein SSX2 , sarcoma, synovial, X-chromosome-related 2 , synovial sarcoma, X breakpoint 2B , tumor antigen HOM-MEL-40 , cancer/testis antigen family 5, member 2b , synovial sarcoma, X breakpoint 2 , synovial sarcoma, X breakpoint 3

GENE ID SPEZIES
6757 Homo sapiens
727837 Homo sapiens
741661 Pan troglodytes
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