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Contributes to the lung's defense against inhaled microorganisms. Zusätzlich bieten wir Ihnen Surfactant Protein D Antikörper (128) und Surfactant Protein D Kits (49) und viele weitere Produktgruppen zu diesem Protein an.
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The authors demonstrated that the number and position of glycosylation sites determine viral susceptibility to the neutralizing activity of porcine SP-D.
Data show that interactions of surfactant protein D (pSP-D) with influenza A virus mediated by the N-linked carbohydrate moiety in pSP-D depend on the terminal sialic acids present on this moiety.
The presence of SP-D in endothelial cells which is NO-, PI(3 (zeige PI3 Proteine))K/Akt (zeige AKT1 Proteine)- and Erk (zeige MAPK1 Proteine)-dependent is demonstrated. It suggests a protective role of SP-D in these cells.
The importance of SP-D in innate immunity is underlined by its expression at the potential ports of entry of pathogens: lung, tongue, intestinal tract, thymus, skin, gall bladder, lacrimal gland, esophagus, stomach, kidney, liver, prostate and spleen.
Our data may promote further studies on the morphological development of the aging lung and the role of SP-D in this process.
The experimentally induced alterations were more severe in the SP-D(-/-) than in the WT mice, particularly with respect to the surfactant-storing lamellar bodies which were sometimes extremely enlarged in SP-D(-/-) mice.
these results demonstrate SP-D plays protective roles by inhibiting apoptosis and modulating NF-kappaB-mediated inflammation in CLP-induced acute pancreatic injury .
SP-A (zeige SFTPA1 Proteine)/D double knock-out mice showed increased susceptibility to urinary tract infection
Human and murine data together indicate that SP-A, SP-D and MBL are synthesized in early gestational tissues, and may contribute to regulation of immune response at the feto-maternal interface during pregnancy.
The presence of SP-A (zeige SFTPA1 Proteine) and SP-D in the murine decidua is likely to play a protective role against intrauterine infection during pregnancy.
our results demonstrate that SFTPD deficiency affects female fertility, highlighting roles for SFTPD in ovarian and uterine physiology
the collectin (zeige MBL2 Proteine) Surfactant Protein D is an essential component of host innate immunity to helminths
SP-D protects the ocular surface from S. aureus infection.
Estrogen positively regulates expression of SP-D in the mouse uterus. Progesterone, along with estrogen synergizes SP-D expression, however, when administered alone results in negative regulation.
This review intends to provide a current overview of the genetics, structure and extra-pulmonary functions of the surfactant collectin (zeige MBL2 Proteine) proteins.
Meta-analysis found that serum SP-A/D detection might be useful for differential diagnosis and prediction of survival in patients with idiopathic pulmonary fibrosis.
The findings suggest that SP-D inhibits LPS (zeige IRF6 Proteine)-stimulated production of interleukin-12p40 via the SIRPalpha/ROCK/ERK (zeige EPHB2 Proteine) signaling pathway.
Efficient lipopolysaccharide recognition by SP-D requires multiple binding interactions utilizing the three major ligand-binding determinants in the SP-D binding pocket, with Ca-dependent binding of inner-core heptose accompanied by interaction of anhydro-Kdo (4,7-anhydro-3-deoxy-d-manno (zeige MAN2A1 Proteine)-oct-2-ulosonic acid) with Arg343 and Asp325.
SP-D levels in bronchoalveolar lavage samples were significantly lower in severe asthma compared with healthy controls and mild asthma. Serum SP-D was significantly increased in severe asthma compared with healthy controls and mild asthma.
SP-A (+186A/G) and SP-B (1580C/T) polymorphisms are strongly associated with the risk of respiratory distress syndrome (RDS (zeige PRPH2 Proteine)) in preterm infants. Notably, reduced serum SP-A levels were correlated with a high risk of RDS (zeige PRPH2 Proteine) and may serve as novel biomarkers for RDS (zeige PRPH2 Proteine) detection and monitoring.
Obstructive sleep apnea-hypopnea syndrome pathogenesis was associated with changes in NF-kappaB (zeige NFKB1 Proteine), HIF-1alpha (zeige HIF1A Proteine), and SPD (zeige HOXD13 Proteine) protein expression level
Surfactant protein D levels differed among idiopathic pulmonary fibrosis, pulmonary sarcoidosis and chronic pulmonary obstructive disease.
Elevated levels of SP-D are Associated with Idiopathic Pulmonary Fibrosis.
Data do not support that pSP-D levels influence or reflect the development of subclinical atherosclerosis. However, the data support that SP-D plays a role in the etiology of atherosclerotic disease development.
Elevation of SP-D is found in bronchoalveolar lavage fluid from inoculated lobes of calves infected with bovine adenovirus type 3.
The bSP (zeige KLK6 Proteine)-D gene has 9 exons spanning about 10.5 kb on chromosome 28 at position q1.8. The 5'-upstream sequence has cis (zeige CISH Proteine)-regulatory elements. It has 2 (zeige HAS2 Proteine) polymorphisms in the carbohydrate recognition domain (242 Glu (zeige DCTN1 Proteine)/Val & 268 Ala/Gly).
Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
surfactant protein D
, carbohydrate recognition domain
, lung surfactant protein D
, pulmonary surfactant-associated protein D
, collectin 7
, pulmonary surfactant apoprotein
, surfactant, pulmonary-associated protein D
, surfactant-associated protein, pulmonary 4
, pulmonary surfactant protein D
, surfactant associated protein D