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This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma.
Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 (zeige EZH2 Proteine) to Suz12 and reduce PRC2 chromatin engagement.
lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program.
in the skin epithelium, EED (zeige EED Proteine), Suz12, and Ezh1 (zeige EZH1 Proteine)/2 function largely as subunits of the PRC2 complex and have roles in skin development
Although Suz12 was required for lymphoid development, deletion in individual blood cell lineages revealed that it was dispensable for the development of granulocytic, monocytic, and megakaryocytic cells.
Suz12-dependent recruitment of Tet1 (zeige TET1 Proteine) contributes to epigenetic plasticity throughout cell differentiation.
PRC2 is a tumor suppressor in Emicro-myc (zeige MYC Proteine) lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2 (zeige EZH2 Proteine).
PRC2 supports aberrant self-renewal in a mouse model of MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine);Nras (zeige NRAS Proteine)(G12D) acute myeloid leukemia (zeige BCL11A Proteine).
The distinct expression profile of the identified Suz12 repressed genes in combination with the proliferation genes hold promise as biomarkers for progression of chronic Hepatitis B V infection to Hepatocellular Carcinoma.
polycomb (zeige CBX2 Proteine) proteins BMI1 (zeige BMI1 Proteine) and SUZ12 are required for cell transformation induced by organic arsenic exposure
Data indicate that binding of EZH2 (zeige EZH2 Proteine), SUZ12 and EED (zeige EED Proteine), the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.
PRE-PIK3C2B (zeige PIK3C2B Proteine) interacts directly with YY1 (zeige YY1 Proteine) in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 (zeige YY1 Proteine) to PRE-PIK3C2B (zeige PIK3C2B Proteine) in HEK (zeige EPHA3 Proteine) cells is decreased on knock-down of either YY1 (zeige YY1 Proteine) or SUZ12.
EZH1 (zeige EZH1 Proteine), SUZ12 and UXT (zeige UXT Proteine) work synergistically to regulate pathway activation in the nucleus.
Mutation in the SUZ12 gene is associated with malignant peripheral nerve sheath tumors.
Overexpression of miR (zeige MLXIP Proteine)-105 inhibited cell proliferation, tumorigenesis, migration, invasion, and drug sensitivity, whereas overexpression of suppressor of Zeste 12 homolog antagonized the tumor-suppressive functions of miR (zeige MLXIP Proteine)-105.
Mutations of SUZ12 and EED (zeige EED Proteine) are reported to have tumor suppressive functions. (Review)
The difference in the SUZ12 and CBX8 (zeige CBX8 Proteine) genes expression were significantly divergent between tumors and their marginal tissues.
Activation of EZH2 (zeige EZH2 Proteine) and SUZ12 Regulated by E2F1 (zeige E2F1 Proteine) Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer
Data show that RAS protein activation was the initiating oncogenic event, with polycomb (zeige CBX2 Proteine) repressive complex 2 (PRC2) subunits impairment being a secondary event.
SUZ12 is a key molecule in the regulation of monoallelic expression of IGF2.
Overexpression of Suz12 was associated with lung adenocarcinoma.
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
Suppressor of zeste 12 protein homolog
, polycomb protein suz12
, suppressor of zeste 12 homolog
, suppressor of zeste 12 homolog (Drosophila)
, joined to JAZF1
, polycomb protein SUZ12
, polycomb protein Suz12
, suppressor of zeste 12 protein homolog
, chET 9 protein
, chromatin precipitated E2F target 9 protein
, joined to JAZF1 protein