Suppressor of Variegation 4-20 Homolog 2 (Drosophila) Proteine (SUV420H2)

SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009].. Zusätzlich bieten wir Ihnen Suppressor of Variegation 4-20 Homolog 2 (Drosophila) Antikörper (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SUV420H2 84787 Q86Y97
SUV420H2 232811 Q6Q783
SUV420H2 308345 P0C2N6
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Showing 7 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_Escherichia coli (E. coli) Human GST tag,His tag 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.167,30 €
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HOST_Escherichia coli (E. coli) Maus Unkonjugiert 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
640,00 €
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HOST_Escherichia coli (E. coli) Human GST tag SUV420H2 protein gel. SUV420H2 run on an SDS-PAGE gel and stained with Coomassie blue. 50 μg Anmelden zum Anzeigen 1 bis 3 Tage
469,44 €
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HOST_Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
811,90 €
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SUV420H2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu Suppressor of Variegation 4-20 Homolog 2 (Drosophila) (SUV420H2) Interaktionspartnern

Human Suppressor of Variegation 4-20 Homolog 2 (Drosophila) (SUV420H2) Interaktionspartner

  1. Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri (zeige VANGL2 Proteine)-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes.

  2. The sequences surrounding both methylation sites do not fit to the specificity profile of SUV4-20H1 (zeige SUV420H1 Proteine).

  3. Upregulation of long non-coding RNA PAPAS (zeige PSTPIP1 Proteine) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4 (zeige NEDD4 Proteine)-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2.

  4. One of the most downregulated genes in response to SUV420H2 expression was the Src (zeige SRC Proteine) substrate, tensin-3 (zeige TNS3 Proteine), a focal adhesion protein that contributes to cancer cell migration.

  5. The crystal structure of SUV420H2 was used to characterize substrate selectivity and product specificity.

  6. SUV420H1 (zeige SUV420H1 Proteine) and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation

  7. data indicate that H4K20me3 invokes gene repression by antagonizing hMOF (zeige KAT8 Proteine)-mediated H4K16Ac

  8. The decrease in trimethylation of lysine 20 of histone H4 in breast cancer cells was accompanied by diminished expression of Suv4-20h2 histone methyltransferase.

Mouse (Murine) Suppressor of Variegation 4-20 Homolog 2 (Drosophila) (SUV420H2) Interaktionspartner

  1. expression of Suv4-20h2 leads to sustained levels of H4K20me3, developmental arrest, and defects in S-phase progression.

  2. Upregulation of long non-coding RNA PAPAS (zeige PSTPIP1 Proteine) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2.

  3. Results uncover a lncRNA-mediated mechanism that guides Suv4-20h2 to specific genomic loci to establish a more compact chromatin structure in growth-arrested cells.

  4. Data suggest that Suv4-20h1 (zeige SUV420H1 Proteine)/Suv4-20h2 activity is required for fidelity of chromosome distribution during meiosis in oocyte; Suv4-20h1 (zeige SUV420H1 Proteine)/Suv4-20h2 appear to control histone 4 methylation, centromere structure, and oocyte maturation/oogenesis.

  5. Suv4-20h2 is involved in the initial loading or maintenance of cohesion subunits

  6. SUV420H1 (zeige SUV420H1 Proteine) and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation

Suppressor of Variegation 4-20 Homolog 2 (Drosophila) (SUV420H2) Protein Überblick

Protein Überblick

SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004

Genbezeichner und Symbole assoziert mit SUV420H2

  • suppressor of variegation 4-20 homolog 2 (Drosophila) (SUV420H2)
  • suppressor of variegation 4-20 homolog 2 (Drosophila) (suv420h2)
  • suppressor of variegation 4-20 homolog 2 (SUV420H2)
  • suppressor of variegation 4-20 homolog 2 (suv420h2)
  • suppressor of variegation 4-20 homolog 2 (Drosophila) (Suv420h2)
  • BC024816 Protein
  • KMT5C Protein
  • Suv4-20h2 Protein
  • zgc:162876 Protein

Bezeichner auf Proteinebene für SUV420H2

suppressor of variegation 4-20 homolog 2 (Drosophila) , Suv4-20-like , suppressor of variegation 4-20 protein-like 2 , histone-lysine N-methyltransferase SUV420H2-like , histone-lysine N-methyltransferase SUV420H2 , su(var)4-20 homolog 2 , suv4-20h2 , lysine N-methyltransferase 5C

GENE ID SPEZIES
484295 Canis lupus familiaris
519777 Bos taurus
569041 Danio rerio
699963 Macaca mulatta
735868 Pan troglodytes
100055743 Equus caballus
100478438 Ailuropoda melanoleuca
100519093 Sus scrofa
100599527 Nomascus leucogenys
779432 Xenopus laevis
84787 Homo sapiens
232811 Mus musculus
308345 Rattus norvegicus
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