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Sulfatase Modifying Factor 1 Proteine (SUMF1)

SUMF1 encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Zusätzlich bieten wir Ihnen SUMF1 Antikörper (57) und SUMF1 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SUMF1 285362 Q8NBK3
SUMF1 58911 Q8R0F3
Ratte SUMF1 SUMF1 362409  
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Top SUMF1 Proteine auf antikoerper-online.de

Showing 10 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 11 bis 15 Tage
303,81 €
Details
HOST_Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
392,86 €
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
548,57 €
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HOST_Human Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
214,29 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.784,92 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
403,06 €
Details
HOST_HEK-293 Cells Human Unkonjugiert Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
328,90 €
Details

SUMF1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, ,
Mouse (Murine)

Am meisten referenzierte SUMF1 Proteine

  1. Human SUMF1 Protein expressed in Escherichia coli (E. coli) - ABIN667612 : Cosma, Pepe, Annunziata, Newbold, Grompe, Parenti, Ballabio: The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. in Cell 2003 (PubMed)
    Zeige alle 2 Referenzen für ABIN667612

Weitere Proteine zu Sulfatase Modifying Factor 1 (SUMF1) Interaktionspartnern

Human Sulfatase Modifying Factor 1 (SUMF1) Interaktionspartner

  1. SUMF1 catalyses a monooxygenase type of reaction.

  2. This detailed clinical description and follow-up of a cohort of patients, together with the molecular characterisation of their underlying defects, contribute to improved knowledge of multiple sulfatase deficiency.

  3. MSD (zeige MESDC2 Proteine) presenting in the newborn period with hypotonia, apnoea, cyanosis and rolling eyes, hepato-splenomegaly and deafness. This patient was compound heterozygous for two so far undescribed SUMF1 mutations (c.191C > A; p.S64X and c.818A > G; p.D273G

  4. The complete kinetic parameters for both forms of FGE are described, along with a proposed mechanism for FGE catalysis that accounts for the copper-dependent activity.

  5. A novel missense mutation & an insertional truncating mutation in SUMF1 gene causing nultiple sulphatase deficiency.

  6. furin (zeige FURIN Proteine)-mediated processing of FGE during secretion is a physiological means of higher eukaryotic cells to regulate FGE activity upon exit from the endoplasmic reticulum

  7. Phenotypic outcome in Multiple Sulfatase Deficiency depends on both residual FGE activity as well as protein stability.

  8. This study identified genetic variation of SUMF1 in genes associated with in vivo glutamate (zeige GRIN1 Proteine) measured using 1H magnetic resonance spectroscopic imaging in the grey matter of patients with multiple sclerosis.

  9. mutational analysis of SUMF1 in 20 Multiple sulfatase deficiency patients of different ethnic origin

  10. characterization of the human Calpha (zeige PRKACA Proteine)-formylglycine-generating enzyme

Mouse (Murine) Sulfatase Modifying Factor 1 (SUMF1) Interaktionspartner

  1. Sumf1(-/-) astrocytes failed to support the survival and function of wild-type cortical neurons, suggesting a non-cell autonomous mechanism for neurodegeneration.

  2. Sumf1 controls hematopoietic stem progenitor cell differentiation and hematopoietic lineage development through FGF and Wnt (zeige WNT2 Proteine) signaling.

  3. Sumf1 is indispensable for sulfatase activation in mice and mammals, differently from bacteria, have a single sulfatase modification system

SUMF1 Protein Überblick

Protein Überblick

This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit SUMF1

  • sulfatase modifying factor 1 (SUMF1)
  • sulfatase modifying factor 1 (Sumf1)
  • AA543204 Protein
  • AAPA3037 Protein
  • AI463102 Protein
  • AI851573 Protein
  • FGE Protein

Bezeichner auf Proteinebene für SUMF1

C-alpha-formylglycine-generating enzyme 1 , FGly-generating enzyme , sulfatase-modifying factor 1 , sulfatase-modifying factor

GENE ID SPEZIES
285362 Homo sapiens
58911 Mus musculus
362409 Rattus norvegicus
536435 Bos taurus
484681 Canis lupus familiaris
100514188 Sus scrofa
Ausgewählte Anbieter für SUMF1 Proteine (SUMF1)
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