Stromal Interaction Molecule 2 (Stim2) ELISA Kits

Stim2 is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. Zusätzlich bieten wir Ihnen Stim2 Antikörper (72) und Stim2 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human Stim2 Stim2 57620 Q9P246
Anti-Maus Stim2 Stim2 116873 P83093
Anti-Ratte Stim2 Stim2 117087  
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Weitere ELISA Kits für Stim2 Interaktionspartner

Human Stromal Interaction Molecule 2 (Stim2) Interaktionspartner

  1. The STIM2 protein play important roles in TGF-beta (zeige TGFB1 ELISA Kits)-induced EMT (zeige ITK ELISA Kits) and these effects are related to both store-operated calcium entry and non-store-operated calcium entry.

  2. What is less clear is how the spatial and temporal spread of intracellular Ca(2 (zeige CA2 ELISA Kits)+) is shaped and regulated by differential expression of the individual SOCE genes and their splice variants, their heteromeric combinations and pre- and posttranslational modifications. This review focuses on principle mechanisms regulating expression, splicing, and targeting of Ca(2 (zeige CA2 ELISA Kits)+) release-activated Ca(2 (zeige CA2 ELISA Kits)+) (CRAC) channels.

  3. While STIM1 (zeige STIM1 ELISA Kits) is a full Orai1 (zeige ORAI1 ELISA Kits)-agonist, leucine-replacement of this crucial residue in STIM2 endows it with partial agonist properties, which may be critical for limiting Orai1 (zeige ORAI1 ELISA Kits) activation stemming from its enhanced sensitivity to store-depletion

  4. STIM2.1 cannot activate Orai1 (zeige ORAI1 ELISA Kits) due to splicing in residues within the channel-activating domain (CAD (zeige CAD ELISA Kits)). STIM2.1 confers a calcium dependent dominant-negative function on both STIM1 (zeige STIM1 ELISA Kits) and STIM2 (STIM2.2). Affinity of the STIM2.1 calmodulin (zeige CALM1 ELISA Kits) binding site within the CAD (zeige CAD ELISA Kits) domain is increased compared to STIM2.2.

  5. STIM2 enhances receptor-stimulated Ca(2 (zeige CA2 ELISA Kits)) signaling by promoting recruitment of STIM1 (zeige STIM1 ELISA Kits) to the endoplasmic reticulum-plasma membrane junctions.

  6. STIM2beta does not by itself strongly bind Orai1 (zeige ORAI1 ELISA Kits), it is recruited to Orai1 (zeige ORAI1 ELISA Kits) channels by forming heterodimers with other STIM isoforms.

  7. Imin channels are regulated by STIM2, TRPC3 (zeige TRPC3 ELISA Kits)-containing INS (zeige INS ELISA Kits) channels are induced by STIM1 (zeige STIM1 ELISA Kits), and TRPC1 (zeige TRPC1 ELISA Kits)-composed Imax channels are activated by both STIM1 (zeige STIM1 ELISA Kits) and STIM2.

  8. The higher amplitude of store-operated Ca2 (zeige CA2 ELISA Kits)+ entry was associated to the over-expression for Stim2, Orai2 (zeige ORAI2 ELISA Kits)-3, and TRPC1 (zeige TRPC1 ELISA Kits) while Stim2 levels remained constant and Stim1 (zeige STIM1 ELISA Kits), Orai1 (zeige ORAI1 ELISA Kits), Orai3 (zeige ORAI3 ELISA Kits), TRPC1 (zeige TRPC1 ELISA Kits) and TRPC4 (zeige TRPC4 ELISA Kits) proteins were over-expressed in primary myelofibrosis.

  9. the reciprocal shift in transient receptor potential channel 1 (TRPC1 (zeige TRPC1 ELISA Kits)) and stromal interaction molecule 2 (STIM2) contributes to Ca2 (zeige CA2 ELISA Kits)+ remodeling and cancer hallmarks in colorectal carcinoma cells

  10. STIM2 is highly expressed and controls store-operated Ca(2 (zeige CA2 ELISA Kits)+) entry in human melanoma. The invasive and migratory potential of melanoma cells was reduced upon silencing of STIM2.

Mouse (Murine) Stromal Interaction Molecule 2 (Stim2) Interaktionspartner

  1. neutrophil cytokine production required STIM2, but not STIM1 (zeige STIM1 ELISA Kits), at least in part as a result of redox regulation of cytokine gene expression

  2. Expression of STIM2 protein rescued CaMKII (zeige CAMK2G ELISA Kits) activity and protected mushroom spines from Abeta42 oligomer toxicity in vitro and in vivo.

  3. SOCE blockers or ablation of STIM1 (zeige STIM1 ELISA Kits), STIM2, or Orai1 (zeige TMEM132A ELISA Kits) severely impaired nucleotide-induced migration and phagocytosis in microglia.

  4. The data from this study indicate that upregulation of STIM2 and Orai2 (zeige ORAI2 ELISA Kits) is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state.

  5. STIM1 (zeige STIM1 ELISA Kits), STIM2, and CRAC channel function play distinct but synergistic roles in CD4 (zeige CD4 ELISA Kits)+ and CD8 (zeige CD8A ELISA Kits)+ T cells during antiviral immunity

  6. STIM2 deficiency significantly delays onset and attenuates the clinical course of experimental allergic encephalitis.

  7. Using mice lacking STIM1 (zeige STIM1 ELISA Kits) and its homologue STIM2, authors find that store-operated calcium entry in CD8 (zeige CD8A ELISA Kits)(+) T cells is required to prevent the engraftment of melanoma and colon carcinoma cells and to control tumour growth.

  8. STIM1 (zeige STIM1 ELISA Kits) and STIM2-mediated store-operated Ca2 (zeige CA2 ELISA Kits)+ influx, leading to efficient activation of NFAT (zeige NFATC1 ELISA Kits) (nuclear factor of activated T cells), is critical for the postselection maturation of agonist-selected T cells.

  9. STIM1 (zeige STIM1 ELISA Kits) and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome.

  10. show that endoplasmic reticulum calcium sensors STIM1 (zeige STIM1 ELISA Kits)- and STIM2-induced store-operated Ca(2 (zeige CA2 ELISA Kits)+) influx is critical for B cell regulatory function

Stim2 Antigen-Profil

Beschreibung des Gens

This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing.

Genbezeichner und Symbole assoziert mit Stim2

  • stromal interaction molecule 2 (STIM2) Antikörper
  • stromal interaction molecule 2 (stim2) Antikörper
  • stromal interaction molecule 2 (Stim2) Antikörper
  • STIM2 Antikörper

Bezeichner auf Proteinebene für Stim2

stromal interaction molecule 2

GENE ID SPEZIES
100083707 Ornithorhynchus anatinus
100471703 Ailuropoda melanoleuca
100566248 Anolis carolinensis
422799 Gallus gallus
461155 Pan troglodytes
541299 Bos taurus
694980 Macaca mulatta
733739 Xenopus (Silurana) tropicalis
100540015 Meleagris gallopavo
57620 Homo sapiens
116873 Mus musculus
117087 Rattus norvegicus
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