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Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis (By similarity). Zusätzlich bieten wir Ihnen Src-Like-Adaptor Antikörper (21) und Src-Like-Adaptor Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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SLAP and SLAP2 are critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke
SLAP is a critical regulator of B-cell development and function and its deficiency leads to decreased autoreactive B cells that are otherwise maintained by inefficient receptor editing or failed negative selection.
Src-like adaptor protein (SLAP) functions as a negative regulator of the granulocyte-macrophage colony-stimulating factor receptor (zeige CSF2RA ELISA Kits) (GM-CSFR (zeige CSF2RA ELISA Kits)) generation of monocyte-derived dendritic cells of bone marrow origin.
SLAP deficiency dramatically reduces both the incidence and severity of arthritis and prevents development of chronic arthritis in the double SKG (mutant ZAP70 (zeige ZAP70 ELISA Kits)) Src-like adapter protein (SLAP) knockout mouse model.
SLAP negatively regulates differentiation of osteoclasts and proliferation of their precursors.
SECp43 (zeige TRNAU1AP ELISA Kits) and SLA (zeige HEPH ELISA Kits) have roles in selenoprotein synthesis [soluble liver antigen]
SLAP functions in a pathway that requires the phosphorylated TCRzeta (zeige CD247 ELISA Kits) chain and the Src (zeige SRC ELISA Kits) family kinase Lck (zeige LCK ELISA Kits), but not ZAP-70 (zeige ZAP70 ELISA Kits) (zeta-associated protein of 70 kD).
SLAP has a conserved function in B and T cells by adapting c-Cbl (zeige CBL ELISA Kits) to the antigen-receptor complex and targeting it for degradation
overexpression of SLalpha and SLbeta enhanced transcription of IGFs, insulin (zeige INS ELISA Kits), leptin (zeige LEP ELISA Kits), sterol regulatory element binding protein 1 (zeige SREBF1 ELISA Kits), and fatty acid synthase (zeige FASN ELISA Kits), as well as expression of vitellogenin (zeige VTG ELISA Kits) and proopiomelanocortin (zeige POMC ELISA Kits) in transgenic larvae
results suggest that cytoplasm-specific transduction of the SH3 and SH2 domains of SLAP has a therapeutic potential of being an immunosuppressive reagent for the treatment of various autoimmune diseases
Taken together the data demonstrate that SLAP negatively regulates wild-type c-Kit (zeige KIT ELISA Kits) signaling, but not its oncogenic counterpart, indicating a possible mechanism by which the oncogenic c-Kit (zeige KIT ELISA Kits) bypasses the normal cellular negative feedback control
upon ligand stimulation SLAP stably associates with Flt3 (zeige FLT3 ELISA Kits) through multiple phosphotyrosine residues in Flt3 (zeige FLT3 ELISA Kits). SLAP mRNA is differentially expressed in different cancers and its expression significantly increased in patients carrying the Flt3 (zeige FLT3 ELISA Kits)-ITD mutation
These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling.
Although SLA is a prominent glucocorticoids response gene, it does not seem to contribute to the anti-leukemic effects of glucocorticoids.
The SLA molecule and its functionally relevant residues have been highly conserved throughout the evolution.
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis (By similarity).
, O-phosphoseryl-tRNA(Sec) selenium transferase
, UGA suppressor tRNA-associated protein
, sec synthase
, selenocysteine synthase
, selenocysteinyl-tRNA(Sec) synthase
, sep-tRNA:Sec-tRNA synthase
, src-like-adapter protein 1
, src-like adapter protein
, src-like adaptor protein
, src-like adaptor