anti-Squalene Epoxidase (SQLE) Antikörper

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. Zusätzlich bieten wir Ihnen Squalene Epoxidase Kits (7) und Squalene Epoxidase Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SQLE 6713 Q14534
SQLE 20775 P52019
SQLE 29230 P52020
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Top anti-Squalene Epoxidase Antikörper auf antikoerper-online.de

Showing 10 out of 26 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Immunohistochemistry analysis in human testis tissue (Formalin-fixed, Paraffin-embedded) using Squalene epoxidase / SQLE Antibody (N-term), followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SQLE antibody for IHC; Clinical relevance has not been evaluated. Western blot analysis in A549 cell line lysates (35ug/lane) using Squalene epoxidase / SQLE Antibody (N-term). This demonstrates the SQLE antibody detected the SQLE protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry: SQLE Antibody [NBP2-32001] - Staining of human placenta shows strong positivity in Decidual cells. Immunohistochemistry: SQLE Antibody [NBP2-32001] - Skin 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Squalene EpoxidasePolyclonal Antibody, Unconjugated (ABIN705401) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$295.90
Details
Human Kaninchen Unkonjugiert IHC (p), WB SQLE Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SQLE antibody detected the SQLE protein (arrow). SQLE Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SQLE Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB Western Blot analysis of SQLE expression in transfected 293T cell line by SQLE MaxPab polyclonal antibody.<br><br>Lane 1: SQLE transfected lysate(63.90 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$418.57
Details
Human Kaninchen Unkonjugiert IHC, WB SQLE antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Hepatocytes (arrows) in Human Liver. Magnification is at 400X SQLE antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$473.93
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cells, using SQLE antibody. 100 μL Anmelden zum Anzeigen 16 Days
$323.13
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$433.13
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: SQLE Antibody [NBP2-32005] - Immunohistochemical staining of human placenta shows distinct cytoplasmic positivity in decidual cells. Immunohistochemistry: SQLE Antibody [NBP2-32005] - Immunohistochemical staining of human placenta shows distinct cytoplasmic positivity in decidual cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
Details

SQLE Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human ,
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, , , , ,
Mouse (Murine)


Rat (Rattus)


Am meisten referenzierte anti-Squalene Epoxidase Antikörper

  1. Human Polyclonal SQLE Primary Antibody für WB - ABIN948500 : Fromont, Godet, Peyret, Irani, Celhay, Rozet, Cathelineau, Cussenot: 8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy. in Human pathology 2013 (PubMed)

  2. Human Polyclonal SQLE Primary Antibody für IHC, IHC (p) - ABIN4355785 : Nguyen, Barozzi, Faronato, Lombardo, Steel, Patel, Darbre, Castellano, Győrffy, Woodley, Meira, Patten, Vircillo, Periyasamy, Ali, Frige, Minucci, Coombes, Magnani: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. in Nature communications 2015 (PubMed)

Weitere Antikörper gegen Squalene Epoxidase Interaktionspartner

Human Squalene Epoxidase (SQLE) Interaktionspartner

  1. Both HMGCR (zeige HMGCR Antikörper) and SQLE promoters have two SREs that may act as a homing region to attract a single SREBP-2 (zeige SREBF2 Antikörper) homodimer.

  2. Higher Gleason grade was associated with lower LDLR (zeige LDLR Antikörper) expression, lower SOAT1 (zeige SOAT1 Antikörper) and higher SQLE expression. Besides high SQLE expression, cancers that became lethal despite primary treatment were characterized by low LDLR (zeige LDLR Antikörper) expression (odds ratio for highest versus lowest quintile, 0.37; 95% CI 0.18-0.76) and by low SOAT1 (zeige SOAT1 Antikörper) expression (odds ratio, 0.41; 95% CI 0.21-0.83).

  3. Data indicate that microRNA miR (zeige MLXIP Antikörper)-133b-dependent squalene epoxidase (SQLE) plays a critical role in the potential metastasis mechanisms in esophageal squamous cell carcinoma (ESCC).

  4. our results pinpoint SQLE as a bona fide metabolic oncogene (zeige RAB1A Antikörper) by amplification, and as a therapeutic target in BC. These findings could have implications in other cancer types.

  5. this study have identified a Squalene Monooxygenase region integrally associated with the endoplasmic reticulum membrane that is likely to interact with cholesterol or respond to cholesterol-induced membrane effects.

  6. overexpression of SQLE in HCC (zeige FAM126A Antikörper) cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of Hepatocellular carcinoma cells in vitro and in vivo.

  7. Data suggest that unsaturated fatty acids (oleate; oleoyl-CoA) stabilize SM/SQLE (which catalyzes 1st oxygenation step in cholesterol synthesis) most likely via inhibition of poly-ubiquitination by MARCH6 (zeige MARCH6 Antikörper) (membrane-associated ring finger (zeige PCGF1 Antikörper) [C3HC4] 6).

  8. MARCH6 and squalene monooxygenase (SM) physically interact, and consistent with MARCH6 acting as an E3 ligase, its overexpression reduces SM abundance in a RING-dependent manner.

  9. A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5 (zeige IGFBP5 Antikörper), SQLE, RAP2B (zeige RAP2B Antikörper), CLDN1 (zeige CLDN1 Antikörper), and TBL1XR1 (zeige TBL1XR1 Antikörper).

  10. Distant metastasis-free survival in stage I/II breast cancer cases was significantly inversely related to SQLE mRNA in multivariate Cox (zeige COX8A Antikörper) analysis in two independent patient cohorts of 160 patients each

Mouse (Murine) Squalene Epoxidase (SQLE) Interaktionspartner

  1. Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.

  2. results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.

  3. Requires a redox partner, but cytochrome p450 reductase (zeige POR Antikörper) is not the only microsomal reductase that will serve this purpose.

Squalene Epoxidase (SQLE) Antigen-Profil

Protein Überblick

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.

Genbezeichner und Symbole assoziert mit SQLE

  • squalene epoxidase (SQLE) Antikörper
  • squalene epoxidase (ANI_1_450034) Antikörper
  • squalene epoxidase (AOR_1_1218114) Antikörper
  • squalene epoxidase (CC1G_03987) Antikörper
  • squalene epoxidase (BDBG_08449) Antikörper
  • squalene epoxidase (MCYG_02365) Antikörper
  • squalene epoxidase (TERG_05717) Antikörper
  • squalene epoxidase (Sqle) Antikörper
  • AI323792 Antikörper
  • An03g03770 Antikörper
  • AO090701000685 Antikörper

Bezeichner auf Proteinebene für SQLE

squalene epoxidase , squalene monooxygenase , SE

GENE ID SPEZIES
100067615 Equus caballus
4980366 Aspergillus niger CBS 513.88
5995549 Aspergillus oryzae RIB40
6007557 Coprinopsis cinerea okayama7130
8508601 Ajellomyces dermatitidis SLH14081
9226506 Arthroderma otae CBS 113480
10376061 Trichophyton rubrum CBS 118892
100125351 Ovis aries
6713 Homo sapiens
608021 Canis lupus familiaris
100113409 Sus scrofa
526535 Bos taurus
20775 Mus musculus
29230 Rattus norvegicus
420335 Gallus gallus
Ausgewählte Anbieter für anti-Squalene Epoxidase (SQLE) Antikörper
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