Sphingosine Kinase 1 Proteine (SPHK1)

The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Zusätzlich bieten wir Ihnen Sphingosine Kinase 1 Antikörper (204) und Sphingosine Kinase 1 Kits (10) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SPHK1 8877 Q9NYA1
SPHK1 20698 Q8CI15
SPHK1 170897 Q91V26
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Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Baculovirus infected Insect Cells Human Unkonjugiert 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
400,00 €
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
822,86 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Baculovirus infected Insect Cells Human GST tag,His tag 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
400,00 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.908,89 €
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Insektenzellen Human GST tag   5 μg Anmelden zum Anzeigen 7 bis 8 Tage
537,60 €
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HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 6 bis 8 Tage
306,74 €
Details

SPHK1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus) ,

Weitere Proteine zu Sphingosine Kinase 1 (SPHK1) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 1 (SPHK1) Interaktionspartner

  1. Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Arabidopsis thaliana Sphingosine Kinase 1 (SPHK1) Interaktionspartner

  1. SPHK/phyto-S1P (zeige MBTPS1 Proteine) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.

  2. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.

Rabbit Sphingosine Kinase 1 (SPHK1) Interaktionspartner

  1. Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (zeige MBTPS1 Proteine) system activates in parallel to viral replication and the inflammatory process induced by the virus.

Human Sphingosine Kinase 1 (SPHK1) Interaktionspartner

  1. we identified sphingosine kinase 1 (SPHK1) as a novel target of miR (zeige MLXIP Proteine)-506, the expression of which inhibited the SPHK1/Akt (zeige AKT1 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signaling pathway, which is activated in pancreatic cancer. High SPHK1 expression was significantly associated with poor survival in a large cohort of pancreatic cancer specimens.

  2. Inhibition of SPHK1 in human acute myeloid leukemia (zeige BCL11A Proteine) cells induces MCL1 (zeige MCL1 Proteine) degradation and caspase (zeige CASP3 Proteine)-dependent cell death.

  3. The analysis suggests that the catalytic function and regulation of SPHK1 and SPHK2 (zeige SPHK2 Proteine) might be dependent on their conformational mobility. (Review)

  4. our data suggest that SphK1 modulates the expression of EMT (zeige ITK Proteine)-related markers and cell migration by regulating the expression of p-FAK (zeige PTK2 Proteine) in CRC (zeige CALR Proteine) cells. Thus, SphK1 may play a functional role in mediating the EMT (zeige ITK Proteine) process in CRC (zeige CALR Proteine).

  5. These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.

  6. By simulating therapeutic strategies that target multiple nodes of the pathway such as Raf and SphK1, we conclude that combination therapy should be much more effective in blocking VEGF signaling to EKR1/2. The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing.

  7. SphK1 is regulated by PDGF (zeige PDGFA Proteine)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (zeige EGR1 Proteine), promoting cell proliferation.

  8. Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (zeige MBTPS1 Proteine) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.

  9. demonstrated the roles played by miR (zeige MLXIP Proteine)-144-3p and FN1 (zeige FN1 Proteine) in mediating the oncogenic function of SphK1, which enhanced the understanding of the etiology of PTC (zeige F9 Proteine)

  10. SphK1 is associated with the proliferation and invasiveness of CRC (zeige CALR Proteine) cells and the SphK1 gene may contribute to a novel therapeutic approach against CRC (zeige CALR Proteine).

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) Interaktionspartner

  1. donor islets from mice deficient in Sphk1 KO contain a reduced number of resident intraislet vascular endothelial cells. The main product of Sphk1, sphingosine-1-phosphate, controls the migration of intraislet endothelial cells in vitro. In vivo, Sphk1 knockout islets have an impaired ability to cure diabetes compared with wild-type controls.

  2. Sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis by stimulation of proliferation of cancer cells.

  3. These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.

  4. Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (zeige S1PR1 Proteine) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.

  5. These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (zeige AGER Proteine)/SphK1 signaling pathway in db/db (zeige LEPR Proteine) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.

  6. Keratinocyte-specific deletion of Traf2 (zeige TRAF2 Proteine), but not Sphk1 deficiency, disrupted TNF (zeige TNF Proteine) mediated NF-kappaB (zeige NFKB1 Proteine) and MAP kinase (zeige MAPK1 Proteine) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.

  7. SphK1 dependent PKC-delta (zeige PKCd Proteine) activation plays an important role in promoting NF-kappaB (zeige NFKB1 Proteine) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (zeige PKCd Proteine) activation might be a potential therapeutic strategy for this disease.

  8. Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (zeige HMGB1 Proteine) cytoplasmic translocation in liver cells.

  9. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo.

  10. transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists

Sphingosine Kinase 1 (SPHK1) Protein Überblick

Protein Überblick

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit Sphingosine Kinase 1 Proteine (SPHK1)

  • Sphingosine kinase 1 (Sk1)
  • sphingosine kinase 1 (SPHK1)
  • sphingosine kinase 1 (sphk1)
  • sphingosine kinase 1 (LOC100357790)
  • sphingosine kinase 1 (Sphk1)
  • 1110006G24Rik Protein
  • CG1747 Protein
  • Dmel\\CG1747 Protein
  • F18E5.160 Protein
  • F18E5_160 Protein
  • Sk1 Protein
  • sphingosine kinase 1 Protein
  • SPHK Protein
  • SPHK1 Protein
  • Spk1 Protein

Bezeichner auf Proteinebene für Sphingosine Kinase 1 Proteine (SPHK1)

CG1747-PA , CG1747-PB , Sk1-PA , Sk1-PB , sphingosine kinase 1 , sphingosine kinase I , SK 1 , SPK 1

GENE ID SPEZIES
32089 Drosophila melanogaster
427803 Gallus gallus
495437 Xenopus laevis
738821 Pan troglodytes
828239 Arabidopsis thaliana
100058875 Equus caballus
100357790 Oryctolagus cuniculus
8877 Homo sapiens
20698 Mus musculus
618605 Bos taurus
170897 Rattus norvegicus
483329 Canis lupus familiaris
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