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The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Zusätzlich bieten wir Ihnen Sphingosine Kinase 1 Antikörper (199) und Sphingosine Kinase 1 Kits (10) und viele weitere Produktgruppen zu diesem Protein an.
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Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila
SPHK/phyto-S1P (zeige MBTPS1 Proteine) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.
Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (zeige MBTPS1 Proteine) system activates in parallel to viral replication and the inflammatory process induced by the virus.
our data suggest that SphK1 modulates the expression of EMT (zeige ITK Proteine)-related markers and cell migration by regulating the expression of p-FAK (zeige PTK2 Proteine) in CRC (zeige CALR Proteine) cells. Thus, SphK1 may play a functional role in mediating the EMT (zeige ITK Proteine) process in CRC (zeige CALR Proteine).
These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.
By simulating therapeutic strategies that target multiple nodes of the pathway such as Raf and SphK1, we conclude that combination therapy should be much more effective in blocking VEGF signaling to EKR1/2. The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing.
SphK1 is regulated by PDGF (zeige PDGFA Proteine)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (zeige EGR1 Proteine), promoting cell proliferation.
Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (zeige MBTPS1 Proteine) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.
demonstrated the roles played by miR (zeige MLXIP Proteine)-144-3p and FN1 (zeige FN1 Proteine) in mediating the oncogenic function of SphK1, which enhanced the understanding of the etiology of PTC (zeige F9 Proteine)
SphK1 is associated with the proliferation and invasiveness of CRC (zeige CALR Proteine) cells and the SphK1 gene may contribute to a novel therapeutic approach against CRC (zeige CALR Proteine).
The levels of SphK1 were significantly increased in triple-negative breast cancer patients compared with normal controls. SphK1 knockdown with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion, suggesting that SphK1 has an important role in TNBC.
SPHK1 mRNA is up-regulation in colorectal cancer.
Found that upregulation of SphK1 expression in the stiff substrate is dominant in metastatic cancer cells but not in primary cancer cells. These results suggest that alterations in the mechanical environment of the extracellular matrix surrounding the tumor cells actively regulate cellular properties such as secretion, which in turn, may contribute to cancer progression.
Sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis by stimulation of proliferation of cancer cells.
Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (zeige S1PR1 Proteine) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.
These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (zeige AGER Proteine)/SphK1 signaling pathway in db/db (zeige LEPR Proteine) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.
Keratinocyte-specific deletion of Traf2 (zeige TRAF2 Proteine), but not Sphk1 deficiency, disrupted TNF (zeige TNF Proteine) mediated NF-kappaB (zeige NFKB1 Proteine) and MAP kinase (zeige MAPK1 Proteine) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.
SphK1 dependent PKC-delta (zeige PKCd Proteine) activation plays an important role in promoting NF-kappaB (zeige NFKB1 Proteine) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (zeige PKCd Proteine) activation might be a potential therapeutic strategy for this disease.
Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (zeige HMGB1 Proteine) cytoplasmic translocation in liver cells.
Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo.
transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists
Based on these findings, the authors propose new roles for SK1 in affecting innate responses that regulate susceptibility to dengue virus infection.
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, sphingosine kinase 1
, sphingosine kinase I
, SK 1
, SPK 1