anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Antikörper

The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Zusätzlich bieten wir Ihnen Sphingomyelin phosphodiesterase 1, Acid Lysosomal Kits (34) und Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SMPD1 6609 P17405
SMPD1 20597 Q04519
SMPD1 308909  
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Top anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antikörper auf antikoerper-online.de

Showing 10 out of 72 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit Target Name: SMPD1 Sample Tissue: Human THP-1 Whole Cell Antibody Dilution: 1ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB SMPD1 Antibody (C-term) (ABIN656161) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Western blot analysis of Acid Sphingomyelinase expression in A431 (A), HepG2 (B), SP2/0 (C), H9C2 (D) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Fledermaus Kaninchen Unkonjugiert IHC (p), WB Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$676.50
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details
Human Kaninchen Alexa Fluor 594 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen Unkonjugiert WB Western Blot: SMPD1 Antibody [NBP1-69267] - This Anti-SMPD1 antibody was used in Western Blot of Fetal Heart tissue lysate at a concentration of 1ug/ml. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cell lines, using SMPD1 antibody. Immunofluorescence analysis of HeLa cell using SMPD1 antibody. Blue: DAPI for nuclear staining. 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: SMPD1 Antibody [NBP2-20426] - Immunohistochemical analysis of paraffin-embedded Breast ca, using antibody at 1:500 dilution. Western Blot: SMPD1 Antibody [NBP2-20426] - Sample (30 ug of whole cell lysate) A: Raji 10% SDS PAGE gel, diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details

SMPD1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antikörper

  1. Human Polyclonal SMPD1 Primary Antibody für FACS, IHC (p) - ABIN656161 : Ullio, Casas, Brunk, Sala, Fabriàs, Ghidoni, Bonelli, Baccino, Autelli: Sphingosine mediates TNF?-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. in Journal of lipid research 2012 (PubMed)

Weitere Antikörper gegen Sphingomyelin phosphodiesterase 1, Acid Lysosomal Interaktionspartner

Cow (Bovine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Interaktionspartner

  1. results provide evidence that translocated lysosomal V1 H(+)-ATPase (zeige ATP6AP1 Antikörper) contributes to formation of local acid microenvironment to facilitate activation of ASM and consequent membrane raft(MR) aggregation, forming MR redox signalosomes and mediating redox signaling in coronary endothelial cells

  2. Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.

  3. Report lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.

Human Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Interaktionspartner

  1. Enzyme activities (acid alpha-glucosidase (GAA), galactocerebrosidase (GALC (zeige GALC Antikörper)), glucocerebrosidase (GBA (zeige GBA Antikörper)), alpha-galactosidase A (GLA (zeige GLA Antikörper)), alpha-iduronidase (IDUA (zeige IDUA Antikörper)) and sphingomyeline phosphodiesterase-1 (SMPD-1)) were measured on ~43,000 de-identified dried blood spot (DBS (zeige MCF2L Antikörper)) punches, and screen positive samples were submitted for DNA sequencing to obtain genotype confirmation of disease risk

  2. This study shows that the ASM alternative splicing pattern could be a biological target with diagnostic relevance and could serve as a novel biomarker for Major depressive disorder

  3. stress-induced activation of p38 MAPK (zeige MAPK14 Antikörper) and apoptosis in endothelial cells and established the link between the acid sphingomyelinase/ceramide and p38 MAPK (zeige MAPK14 Antikörper) pathways.

  4. Elevated acid sphingomyelinase (ASM) activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC).

  5. this is the largest study on mutation analysis of patients with ASM-deficient Niemann-Pick disease reported in literature and also the first study on the SMPD1 gene mutation spectrum in India.

  6. ASM and ceramides, together with STX6 (zeige STX6 Antikörper) and cholesterol, constitute a new regulatory mechanism for the exit of Met from the Golgi during its biosynthetic route.

  7. the p.Ala359Asp mutation causes structural alterations in the hydrophobic environment where ASM is located, decreasing its enzymatic activity

  8. Airway cells with lower SMPD1 activity increases neutrophil chemotaxis towards them.

  9. The results identify acid sphingomyelinase as a novel target of Lycium Chinense berries to decrease saturated/unsaturated fatty acid sphingomyelin ratio, known to be useful for cell health. Consistent with these data, the berries regulate specifically gene expression to protect cells from apoptosis.

  10. ASMase mediated the 50-Hz MF-induced EGFR (zeige EGFR Antikörper) clustering via ceramide which was produced from hydrolyzation on lipid rafts

Mouse (Murine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Interaktionspartner

  1. The results show that mice lacking acid sphingomyelinase had a significant increase in myelin recovery and a significantly higher oligodendrocyte cell count after 2 weeks remyelination compared to wildtype littermates.

  2. These findings suggest that the paradoxical antidepressant effects of alcohol in depressed organisms are mediated by ASM and its control of sphingolipid homeostasis

  3. this study shows that Asm-deficient mice develop brain measles virus infection that is consistent with an enhanced Treg frequency and/or activity

  4. K8/K18 (zeige KRT18 Antikörper)-dependent PKCdelta (zeige PKCd Antikörper)- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (zeige KRT18 Antikörper) loss.

  5. Aged platelets elicit lung injury in primed recipient mice, which can be alleviated by pharmacological inhibition or genetic deletion of acid sphingomyelinase.

  6. Transgenic ASM female, but not male, mice showed an impaired social preference and a depressive- and anxiogenic-like phenotype, which could be normalized by amitriptyline treatment.

  7. this study shows decreased T cell numbers in Asm-deficient, burn-injured, and microbiota-depleted mice

  8. These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (zeige SELP Antikörper) in platelets, followed by activation and secretion of Asm and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK (zeige MAPK14 Antikörper) acts downstream from P-selectin (zeige SELP Antikörper) and is necessary for the secretion of Asm.

  9. Inhibition of ASM in diabetic CACs improved membrane fluidity and homing of these cells to damaged retinal vessels. Collectively, these findings indicate that selective modulation of sphingolipid metabolism in BM-derived cell populations in diabetes normalizes the reparative/proinflammatory cell balance and can be explored as a novel therapeutic strategy for treating diabetic retinopathy.

  10. Inhibition of the smpd1 by antidepressants prevents stress-induced phosphorylation/activation of p38K indicating that antidepressants indirectly target p38K via the acid sphingomyelinase/ceramide system.

Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Antigen-Profil

Protein Überblick

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.

Genbezeichner und Symbole assoziert mit SMPD1

  • sphingomyelin phosphodiesterase (LOC5578088) Antikörper
  • acid sphingomyelinase (ASM) Antikörper
  • acid sphingomyelinase (AFUA_4G06640) Antikörper
  • sphingomyelin phosphodiesterase 1 (SMPD1) Antikörper
  • sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1) Antikörper
  • sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1) Antikörper
  • sphingomyelin phosphodiesterase 1 (Smpd1) Antikörper
  • A-SMase Antikörper
  • Afu4g06640 Antikörper
  • ASM Antikörper
  • aSMase Antikörper
  • NPD Antikörper
  • SMPD1 Antikörper
  • Zn-SMase Antikörper

Bezeichner auf Proteinebene für SMPD1

sphingomyelin phosphodiesterase , acid sphingomyelinase , sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) , sphingomyelin phosphodiesterase 1, acid lysosomal , sphingomyelin phosphodiesterase 1 , sphingomyelin phosphodiesterase-like , aSMase

GENE ID SPEZIES
5578088 Aedes aegypti
280724 Bos taurus
3509254 Aspergillus fumigatus Af293
450990 Pan troglodytes
711248 Macaca mulatta
100030863 Monodelphis domestica
100172518 Pongo abelii
100307047 Ovis aries
100353898 Oryctolagus cuniculus
100400920 Callithrix jacchus
6609 Homo sapiens
485334 Canis lupus familiaris
505097 Bos taurus
20597 Mus musculus
308909 Rattus norvegicus
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