anti-Spastic Paraplegia 7 (SPG7) Antikörper

SPG7 encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Zusätzlich bieten wir Ihnen SPG7 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SPG7 6687 Q9UQ90
SPG7 234847 Q3ULF4
SPG7 353231 Q7TT47
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Showing 10 out of 76 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Immunohistochemistry analysis in human brain tissue (Formalin-fixed, Paraffin-embedded) using Paraplegin / SPG7  Antibody , followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SPG7 antibody for IHC; Clinical relevance has not been evaluated. Western blot analysis in 293 cell line lysates (35ug/lane) using Paraplegin / SPG7  Antibody . This demonstrates the SPG7 antibody detected the SPG7 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Hund Maus Unkonjugiert FACS, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence: SPG7 Antibody (1C1) [NBP2-01860] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY SPG7. Western Blot: SPG7 Antibody (1C1) [NBP2-01860] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SPG7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SPG7. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Human Maus Unkonjugiert FACS, IF, WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details
Human Kaninchen Unkonjugiert IHC (p), WB SPG7 Antibody (Center) (ABIN656408) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details
Human Maus Unkonjugiert IF, WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
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Human Maus Unkonjugiert FACS, IF, WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with SPG7/Paraplegin Polyclonal Antibody, Unconjugated (bs-11761R) at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$295.90
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extract of various cells, using SPG7 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$323.13
Details
Human Maus Unkonjugiert IHC, WB Immunohistochemistry: SPG7 Antibody (1G4) [NBP2-45943] - Analysis of Human liver tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Immunohistochemistry: SPG7 Antibody (1G4) [NBP2-45943] - Analysis of Carcinoma of Human liver tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details

SPG7 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-SPG7 Antikörper

  1. Dog (Canine) Monoclonal SPG7 Primary Antibody für FACS, ICC - ABIN4355648 : Kim, Lee, Cho, Kim, Won: Dopamine D3 receptor-modulated neuroprotective effects of lisuride. in Neuropharmacology 2017 (PubMed)

Weitere Antikörper gegen SPG7 Interaktionspartner

Human Spastic Paraplegia 7 (SPG7) Interaktionspartner

  1. Compound heterozygous variants in SPG7 identified in 22 French Canadian patients with spastic ataxia.

  2. CACNA1A and SPG7 are major ataxia genes.

  3. The results of this study showed that the most frequently detected variant in this cohort was the SPG7 p.Leu78.

  4. A Norwegian founder mutation p.H701P is a major cause of SPG7 in Norway.

  5. a novel homozygous frameshift deletion in the SPG7 gene was identifies as the genetic cause of hereditary spastic paraplegia in a Greek family.

  6. this case shows that the spectrum of pathologies in SPG7 can include neuron loss of the dentate nucleus and the inferior olivary nucleus as well as neuritic pathology.

  7. Data indicates that SPG7 is essential for the mitochondrial permeability transition pore (PTP) complex formation, interacts with CypD and VDAC and determines C terminus of SPG7 and CsA-binding region of CypD as necessary for PTP formation.

  8. In unexplained ataxia, there was a significant number of patients with SPG7 mutations.

  9. The SPG7 Q866 variant is efficiently processed independent of phosphorylation of AFG3L2 (zeige AFG3L2 Antikörper) at Y179, which inhibits processing of SPG7.

  10. Using an unbiased exome sequencing approach we identified pathogenic compound heterozygous SPG7 mutations in patients with PEO (zeige POLG Antikörper) and multiple mitochondrial DNA deletions in skeletal muscle

Mouse (Murine) Spastic Paraplegia 7 (SPG7) Interaktionspartner

  1. Studies indicate that both mouse and human SPG7 ESTs containing alternative first exons.

  2. These results provide evidence for different substrate specificities of m-AAA (zeige AAAS Antikörper) proteases and reveal a striking evolutionary switch of proteases involved in the proteolytic processing of dynamin (zeige DNM1 Antikörper)-like GTPases in mitochondria.

  3. Data show that Afg3l1 or Afg3l2 are required for maturation of newly imported paraplegin subunits after their cleavage by MPP.

  4. Spg7 and Afg3l2 (zeige AFG3L2 Antikörper) double mutants show an early-onset ataxic phenotype, indicating a role of the m-AAA (zeige AAAS Antikörper) proteases in cerebellar degeneration.

SPG7 Antigen-Profil

Protein Überblick

This gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7.

Genbezeichner und Symbole assoziert mit SPG7

  • SPG7, paraplegin matrix AAA peptidase subunit (SPG7) Antikörper
  • SPG7, paraplegin matrix AAA peptidase subunit (Spg7) Antikörper
  • AI452278 Antikörper
  • AU015315 Antikörper
  • CAR Antikörper
  • Cmar Antikörper
  • PGN Antikörper
  • SPG5C Antikörper

Bezeichner auf Proteinebene für SPG7

paraplegin , spastic paraplegia 7 , spastic paraplegia 7 homolog , spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) , cell adhesion regulator , cell matrix adhesion regulator , spastic paraplegia 7 protein

GENE ID SPEZIES
415843 Gallus gallus
6687 Homo sapiens
234847 Mus musculus
353231 Rattus norvegicus
Ausgewählte Anbieter für anti-SPG7 (SPG7) Antikörper
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