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SP3 belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. Zusätzlich bieten wir Ihnen Sp3 Transcription Factor Kits (1) und und viele weitere Produktgruppen zu diesem Protein an.
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we established a new regulatory model of COL1A1 (zeige COL1A1 Antikörper) regulation by HIF-1 (zeige HIF1A Antikörper), and bring out its relationship with Sp3 transcription factor. In a fundamental level, these findings give insights in the mechanisms controlling COL1A1 (zeige COL1A1 Antikörper) gene expression.
Data indicate that the antitumor activity of trefoil factor 2 (TFF2 (zeige TFF2 Antikörper)) is mediated by an interaction with the transcription factor Sp3 (Sp3) in gastric cancer cells.
demonstrate that a 186bp region is the minimal essential region and that Sp3-GC1 (zeige OLFM4 Antikörper) binding is essential to the basal expression of KLF5 (zeige KLF5 Antikörper)
Sp1 (zeige PSG1 Antikörper) and Sp3 are not only essential for the basal transcription of the ek1 (zeige EPHA3 Antikörper) gene, their accessibility to the target site on the ek1 (zeige EPHA3 Antikörper) promoter is regulated by histone protein modification in a cell line dependent manner.
Human SP1 and SP3 transcription factors regulate MALAT1 expression in hepatocellular carcinoma.
result indicated that promoter binding by Sp1 (zeige PSG1 Antikörper)/Sp3 was essential, but not a limiting step, for hTERT transcription
Sp3 was found to be a major regulator of BNIP3 (zeige BNIP3 Antikörper) in prostate cancer.
stimulates CCR7 (zeige CCR7 Antikörper) expression during the course of dendritic cell maturation
O-GlcNAc modification of Sp3 and Sp4, but not Sp2 transcription factors negatively regulates their transcriptional activities.
characterized two evolutionary highly conserved cis (zeige CISH Antikörper)-regulatory modules (CRMs) within the proximal promoter each composed of one binding site for the transcription factors SP1 (zeige PSG1 Antikörper) and SP3 as well as for the nuclear transcription factor Y (zeige NFYA Antikörper)
This resulted in Sp1 (zeige SP1 Antikörper) displacement from the promoter and binding of Sp3 to it, leading to p300 (zeige NOTCH1 Antikörper) recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 (zeige TLR5 Antikörper) expression in the intestine. Additionally, a novel insight is gained into Sp1 (zeige SP1 Antikörper)/Sp3-mediated gene regulation that may apply to other genes
Sp3 binds and activates the FGFR4 (zeige FGFR4 Antikörper) promoter.
Dp71 (zeige DMD Antikörper) expression in hepatic cells is carried out, in part, by YY1 (zeige YY1 Antikörper)-, Sp1 (zeige SP1 Antikörper)- and Sp3-mediated transcription from the Dp71 (zeige DMD Antikörper) promoter.
Our results unveil strikingly different recruitment mechanisms of Sp1 (zeige SP1 Antikörper)/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
Sp1 (zeige SP1 Antikörper)/Sp3 transcription factors have roles in regulating hallmarks of megakaryocyte maturation and platelet formation and function
Sp1 (zeige SP1 Antikörper)/3 transcription factors trigger Mina (zeige MINA Antikörper) expression through additive activity targeted to a cluster of four Sp1 (zeige SP1 Antikörper)/3 binding sites forming the P1 promoter.
an interplay between Sp1 (zeige SP1 Antikörper) and Sp3 as a mechanism involved in the control of Fiat (zeige TXLNG Antikörper) gene expression in osteoblasts.
Oct-6 (zeige POU3F1 Antikörper) and Oct-11 (zeige POU2F3 Antikörper) contribute to the regulation of loricrin (zeige LOR Antikörper) gene transcription via interaction with AP-1 (zeige JUN Antikörper) factors and Sp1 (zeige SP1 Antikörper)/Sp3.
inhibition of FGF-10 (zeige FGF10 Antikörper) by inflammatory signaling involves the NF-kappaB (zeige NFKB1 Antikörper)-dependent interactions between RELA (zeige NFkBP65 Antikörper), SP3, and the Fgf-10 (zeige FGF10 Antikörper) promoter.
Three GC boxes within the proximal promoter of the murine pyruvate carboxylase (zeige PC Antikörper) gene bind Sp1 (zeige SP1 Antikörper)/Sp3
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13.
Sp3 transcription factor
, sp3 transcription factor
, transcription factor Sp3
, specificity protein 3
, GC-binding transcription factor Sp3