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SNX3 encodes a member of the sorting nexin family. Zusätzlich bieten wir Ihnen Sorting Nexin 3 Antikörper (86) und viele weitere Produktgruppen zu diesem Protein an.
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SNX3-retromer complex regulates the surface expression and function of PC1 (zeige PCSK1 Proteine) and PC2 (zeige KRT6B Proteine)
X-ray crystallographic analysis of a 4-component complex comprising the VPS26 (zeige VPS26A Proteine) & VPS35 (zeige vps35 Proteine) subunits of retromer, sorting nexin SNX3, & recycling signal from the divalent cation transporter DMT1 (zeige DMRT1 Proteine)-II; analysis identifies a binding site for canonical recycling signals at the interface between VPS26 (zeige VPS26A Proteine) & SNX3; shows cooperative interactions among the VPS subunits, SNX3 & cargo that couple signal-recognition to membrane recruitment.
Data show that over-expression of sorting nexin 3 (hSNX3) alters the morphology of colon cancer SW620 cells, but hardly affects cell migration.
SNX3 negatively regulates phagocytosis in DC possibly by modulating recruitment of essential PI3P lipid-binding proteins of the phagocytic pathways, such as EEA1 (zeige EEA1 Proteine), to phagosomal membranes.
This study found that four significant SNX3 SNPs in the discovery sample were replicated in a community-based sample of Israeli-Arabs
SNX3 and SNX5 play essential roles in the aspirin-mediated accumulation of endocytosed-TfnR at the early/sorting endosome
SNX3 plays a significant role in regulating the maturation of Salmonella containing vacuoles.
Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype
we cannot exclude the possibility that deletions at SNX3 may underlie MMEP, given that sequencing is unable to distinguish between homozygosity across loci versus large deletions
Data show that Hrs is essential for lysosomal targeting but not multivesicular body biogenesis and transport to late endosomes, while SNX3 is required for multivesicular body formation, but not for EGF receptor (zeige EGFR Proteine) degradation.
Snx3 regulates recycling of the transferrin receptor and iron assimilation.
Snx3 mRNA is expressed during neural development and in adult neural tissues, suggesting that SNX3 may play an important role in the development and function of the central nervous system.
vasopressin (zeige AVP Proteine)-induced Usp10 (zeige USP10 Proteine) deubiquitylates and stabilizes endogenous SNX3 and consequently promotes cell surface expression of ENaC (zeige SCNN1A Proteine)
SNX3 promotes neurite outgrowth even in the presence of serum and that its short basic C-terminal sequence, as well as the PX domain, binds to phosphatidylinositol monophosphates.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking.
, sorting nexin 3
, potential GRD19-like sorting nexin
, sorting nexin 3A