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SNX15 encodes a member of the sorting nexin family. Zusätzlich bieten wir Ihnen SNX15 Antikörper (56) und SNX15 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
SNX15 regulates the recycling of APP (zeige APP ELISA Kits) to cell surface and, thus, its processing for Abeta (zeige APP ELISA Kits) generation.
The activated EGF receptor (zeige EGFR ELISA Kits) enters distinct sub-populations of SNX15- and APPL1 (zeige APPL1 ELISA Kits)-labelled peripheral endocytic vesicles.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.
sorting nexin 15
, clone iota unknown protein
, sorting nexin-15