Sorbitol Dehydrogenase Proteine (SORD)

Sorbitol dehydrogenase (SORD\; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1\; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). Zusätzlich bieten wir Ihnen Sorbitol Dehydrogenase Antikörper (146) und Sorbitol Dehydrogenase Kits (38) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SORD 20322 Q64442
SORD 6652 Q00796
SORD 24788 P27867
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Showing 10 out of 25 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$315.00
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$286.00
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Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$548.63
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
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Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 2 bis 3 Tage
$189.38
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Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
Details

SORD Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , , , , ,
, , ,
Rat (Rattus) ,

Weitere Proteine zu Sorbitol Dehydrogenase (SORD) Interaktionspartnern

Mouse (Murine) Sorbitol Dehydrogenase (SORD) Interaktionspartner

  1. Nicotine-induced reduced expression of Sord could be involved in impaired secretory functions of the epididymis.

  2. Knockout mice had the highest sorbitol content among various genetic types including mice wwith human aldose reductase (zeige AKR1B1 Proteine).

  3. The zinc-finger protein ZAC1 (zeige PLAGL1 Proteine) is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.

Human Sorbitol Dehydrogenase (SORD) Interaktionspartner

  1. SDH gene expression was increased by hypoxia and oxidative stress, but not extracellular hyperosmolarity. Hyperosmolarity and hypoxia did not alter the SDH protein level.

  2. One of the most striking changes involved sorbitol dehydrogenase, a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1 (zeige AKR1B1 Proteine)) and related (KHK (zeige KHK Proteine)) pathways.

  3. The SDH level was significantly decreased in patients with proliferative compared with non-proliferative retinopathy in both insulin (zeige INS Proteine) and oral diabetic groups.

  4. Thus, our findings suggest that the -888G > C polymorphism in the SORD gene is not involved in the pathogenesis of diabtic retinopathy in type 2 diabetes.

  5. The expression of SORD is regulated by androgens in human prostate. In prostate cancer, increased immunostaining was associated with high Gleason patterns and high serum PSA concentrations.

  6. crystals of sorbitol dehydrogenase belong to the monoclinic C2 space group, with unit-cell parameters a = 145.9, b = 52.3, c = 169.0 A, beta = 101.8 degrees

  7. Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme.

  8. Results compare the catalytic mechanism of liver sorbitol dehydrogenase with wild-type and Glu154-->Cys (zeige DNAJC5 Proteine) forms of yeast xylitol dehydrogenase.

  9. The zinc-finger protein ZAC1 (zeige PLAGL1 Proteine) is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte.

Sorbitol Dehydrogenase (SORD) Protein Überblick

Protein Überblick

Sorbitol dehydrogenase (SORD\; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1\; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995

Genbezeichner und Symbole assoziert mit Sorbitol Dehydrogenase Proteine (SORD)

  • sorbitol dehydrogenase L homeolog (sord.L)
  • sorbitol dehydrogenase (sord)
  • sorbitol dehydrogenase (Sdh)
  • sorbitol dehydrogenase (LOC733025)
  • sorbitol dehydrogenase (polS)
  • sorbitol dehydrogenase (RS_RS10765)
  • sorbitol dehydrogenase (sdh)
  • sorbitol dehydrogenase (smoS)
  • sorbitol dehydrogenase (Rsph17029_1731)
  • Sorbitol dehydrogenase (Srd)
  • sorbitol dehydrogenase (RSKD131_1411)
  • sorbitol dehydrogenase (Sord)
  • sorbitol dehydrogenase (SORD)
  • BmSDH Protein
  • MGC83437 Protein
  • PSPTO0363 Protein
  • SDH Protein
  • Sdh-1 Protein
  • Sdh1 Protein
  • SODH-1 Protein
  • sord Protein
  • SORD1 Protein

Bezeichner auf Proteinebene für Sorbitol Dehydrogenase Proteine (SORD)

sorbitol dehydrogenase , L-iditol 2-dehydrogenase , mammalian sorbitol dehydrogenase homolog , sorbitol dehydrogenase 1

GENE ID SPEZIES
446317 Xenopus laevis
496715 Xenopus (Silurana) tropicalis
692742 Bombyx mori
733025 Bombyx mori
1181972 Pseudomonas syringae pv. tomato str. DC3000
1220989 Ralstonia solanacearum GMI1000
3690081 Burkholderia pseudomallei 1710b
3719926 Rhodobacter sphaeroides 2.4.1
4897512 Rhodobacter sphaeroides ATCC 17029
5656982 Drosophila melanogaster
7358398 Rhodobacter sphaeroides KD131
9746093 Halomonas elongata DSM 2581
20322 Mus musculus
6652 Homo sapiens
415332 Gallus gallus
487535 Canis lupus familiaris
24788 Rattus norvegicus
101115280 Ovis aries
508954 Bos taurus
100158181 Sus scrofa
100173784 Pongo abelii
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