Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 Proteine (SLC7A8)

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Zusätzlich bieten wir Ihnen SLC7A8 Antikörper (39) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC7A8 23428 Q9UHI5
Ratte SLC7A8 SLC7A8 84551 Q9WVR6
SLC7A8 50934 Q9QXW9
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Showing 3 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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SLC7A8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) Interaktionspartnern

Human Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) Interaktionspartner

  1. LAT1 (zeige LAT Proteine) and LAT2 (zeige LAT2 Proteine) are present and functional in the syncytiotrophoblast MVM, whereas LAT2 (zeige LAT2 Proteine) is also expressed in the BM and in the fetal capillary endothelium.

  2. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.

  3. the interaction of CD98 (zeige SLC3A2 Proteine)/LAT2 (zeige LAT2 Proteine) with ICAM-1 (zeige ICAM1 Proteine), found to be expressed to the basolateral domain, and the potential of such interaction on intracellular signal activation in Caco2-BBE (zeige ENO3 Proteine) cell monolayers

  4. identify LAT1 (zeige LAT Proteine) and LAT2 (zeige LAT2 Proteine) as members of system L that mediate transmembrane movement of l-CSNO

  5. Genetic variation in LAT1 (zeige LAT Proteine) and LAT2 (zeige LAT2 Proteine) does not appear to be a major cause of inter-individual variability in pharmacokinetics and of adverse reactions to melphalan.

Mouse (Murine) Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) Interaktionspartner

  1. Circulating thyroid hormones, thyrotropin and thyroid hormone-responsive (zeige THRSP Proteine) genes remained unchanged in Slc7a8(-/-) mice, possibly because of functional compensation by the thyroid hormone (zeige PTH Proteine) transporter Mct8 (zeige MCT8 Proteine), which is co-expressed in many cell types

  2. the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc (zeige SLC3A2 Proteine), by recycling its aromatic influx substrates

  3. The positive effect of non-T cell activation linker (NTAL (zeige LAT2 Proteine)) on Akt (zeige AKT1 Proteine) phosphorylation and mast cell survival requires LAT (zeige LAT Proteine).

  4. LAT1, and LAT2 mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 and NTCP (zeige SLC10A1 Proteine) mRNAs were not.

SLC7A8 Protein Überblick

Protein Überblick

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (By similarity).

Genbezeichner und Symbole assoziert mit SLC7A8

  • solute carrier family 7 (amino acid transporter light chain, L system), member 8 (slc7a8)
  • solute carrier family 7 (amino acid transporter light chain, L system), member 8 (SLC7A8)
  • solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8)
  • solute carrier family 7 (amino acid transporter light chain, L system), member 8 (Slc7a8)
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (slc7a8)
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (Slc7a8)
  • 4F2LC-5 Protein
  • AA408822 Protein
  • Lat2 Protein
  • Lat4 Protein
  • LPI-PC1 Protein
  • si:ch211-14a17.3 Protein
  • si:zc14a17.3 Protein
  • XAA2 Protein

Bezeichner auf Proteinebene für SLC7A8

solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 , solute carrier family 7 (amino acid transporter, L-type), member 8 , large neutral amino acids transporter small subunit 2 , L-type amino acid transporter 2 , solute carrier family 7 member 8 , integral membrane protein E16H , glycoprotein-associated amino acid transporter LAT2 , 4F2-LC5 , cationic amino acid transporter y+ system , mLAT2 , solute carrier family 8 (cationic amino acid transporter, y+ system), member 7

GENE ID SPEZIES
394580 Xenopus (Silurana) tropicalis
452793 Pan troglodytes
713511 Macaca mulatta
100134829 Sus scrofa
100172820 Pongo abelii
380297 Xenopus laevis
23428 Homo sapiens
490608 Canis lupus familiaris
536818 Bos taurus
100009408 Oryctolagus cuniculus
84551 Rattus norvegicus
368665 Danio rerio
50934 Mus musculus
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