Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 Proteine (SLC6A19)

SLC6A19 encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Zusätzlich bieten wir Ihnen SLC6A19 Antikörper (8) und SLC6A19 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC6A19 74338 Q9D687
SLC6A19 340024 Q695T7
Ratte SLC6A19 SLC6A19 664630 Q2A865
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,041.49
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
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HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$205.80
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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SLC6A19 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) Interaktionspartnern

Mouse (Murine) Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) Interaktionspartner

  1. analysis of the interaction of amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin (zeige TMEM27 Proteine)

  2. Slc6a19 expression in the intestine is regulated at three different levels involving promoter methylation, histone modification, and opposing transcription factors.

  3. the presence of digestive protein complexes in the intestinal brush-border containing the peptidases APN (zeige ANPEP Proteine) and ACE2 (zeige ACE2 Proteine) and the neutral amino acid transporter B0AT1

  4. Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse.

  5. Average loss of solute carrier (zeige SERTAD2 Proteine) expression was similar in acute tubular necrosis (77%) and T cell-mediated rejection (75%) with high correlation of individual transcripts.

  6. Glucocorticoid inducible kinase isoforms SGK1 (zeige SGK1 Proteine)-3 are novel potent stimulators of Slc6a19 and may thus participate in the regulation of neutral amino acid transport in vivo.

  7. We isolated the human homolog of B(0)AT1, called SLC6A19, and determined its size and molecular organization. We then identified mutations in SLC6A19 in members of the original family in whom Hartnup disorder was discovered

  8. The mechanism of the mouse (m)B0AT1 (slc6a19) transporter was studied in detail using two electrode voltage-clamp techniques and tracer studies in the Xenopus oocyte expression system.

  9. The relatively constant [Na(+)] along the renal proximal tubule both drives the uptake of neutral amino acids via B(0)AT1 thermodynamically and ensures that, upon binding, these are translocated efficiently into the cell.

  10. This study shows the luminal brush-border localization of the Na(+)-dependent amino and imino acid transporters B degrees AT1 (zeige SLC33A1 Proteine) and XT3s1/SIT1 (zeige SIT1 Proteine) in kidney and intestine.

Human Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) Interaktionspartner

  1. SIT1 (zeige SIT1 Proteine), B(0)AT1 and ACE2 (zeige ACE2 Proteine) were co-localized in the brush-border membrane of small intestine enterocytes.

  2. PKB/Akt (zeige AKT1 Proteine) up-regulates SLC6A19 activity, which may foster amino acid uptake into PKB/Akt (zeige AKT1 Proteine)-expressing epithelial and tumor cells.

  3. JAK2 (zeige JAK2 Proteine) up-regulates SLC6A19 activity which may foster amino acid uptake into JAK2 (zeige JAK2 Proteine) expressing cells.

  4. Average loss of solute carrier (zeige SERTAD2 Proteine) expression was similar in acute tubular necrosis (77%) and T cell-mediated rejection (75%) with high correlation of individual transcripts.

  5. A novel SLC6A19 gene mutation is associated with late-onset seizures in a Korean patient with Hartnup disorder.

  6. We identified six mutations in SLC6A19 that cosegregated with disease in the predicted recessive manner, with most affected individuals being compound heterozygotes.

  7. Hartnup disorder is allelically heterogeneous with two mutated SLC6A19 allele.

  8. These findings suggest that the rare SLC6A19-MS7 allele may be a risk factor for hypertension.

  9. Suggest that amino acid transporters B(0)AT1 and b(0,+)AT are involved in the reabsorption of L-citrulline in the kidney, at least in part, by mediating the apical membrane transport of L-citrulline in renal tubule cells.

  10. novel homozygous mutation of G284R in the transmembrane domain of the SLC6A19 transporter found in the proband, with typical dermatologic and neurologic manifestations and increased levels of urinary neutral amino acids

SLC6A19 Protein Überblick

Protein Überblick

This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder.

Genbezeichner und Symbole assoziert mit SLC6A19

  • solute carrier family 6 (neurotransmitter transporter), member 19 (Slc6a19)
  • solute carrier family 6 (neutral amino acid transporter), member 19 (SLC6A19)
  • solute carrier family 6 (neutral amino acid transporter), member 19 (Slc6a19)
  • 4632401C08Rik Protein
  • B0at1 Protein
  • B<0>AT1 Protein
  • HND Protein

Bezeichner auf Proteinebene für SLC6A19

b(0)AT1 , sodium-dependent neutral amino acid transporter B(0)AT1 , solute carrier family 6 member 19 , system B(0) neutral amino acid transporter AT1 , sodium-dependent amino acid transporter system B0 , solute carrier family 6 (neurotransmitter transporter), member 19 , system B0 neutral amino acid transporter , neutral amino acid transporter , solute carrier family 6, member 19 , system B0 neutral amino acid transporter SLC6A19 , sodium-dependent neutral amino acid transporter B(0)

GENE ID SPEZIES
74338 Mus musculus
340024 Homo sapiens
664630 Rattus norvegicus
100683912 Canis lupus familiaris
641346 Sus scrofa
100173524 Pongo abelii
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