Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 5 (SLC6A5) ELISA Kits

SLC6A5 encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. Zusätzlich bieten wir Ihnen SLC6A5 Antikörper (17) und SLC6A5 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus SLC6A5 SLC6A5 104245  
Anti-Human SLC6A5 SLC6A5 9152 Q9Y345
Anti-Ratte SLC6A5 SLC6A5 171148 P58295
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Weitere ELISA Kits für SLC6A5 Interaktionspartner

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 5 (SLC6A5) Interaktionspartner

  1. that the deletion of VIAAT (zeige SLC32A1 ELISA Kits) in GlyT2-Cre expressing neurons also strongly affects GABAergic transmission

  2. Results suggest that the excessive GAT-1 (zeige SLC6A1 ELISA Kits) and GlyT-1 (zeige GLYT1 ELISA Kits)/2 heterotransporter-mediated Glu (zeige GCG ELISA Kits) release, in the spinal cord of SOD1 (zeige SOD1 ELISA Kits)(G93A) mice, is due to the heterotransporter over-expression at the nerve terminal membrane, promoted by the excessive Glu (zeige GCG ELISA Kits) exocytosis

  3. Report that in the presence of a GlyT2 mechanism-based toxicity, reversible inhibitors might allow a tolerable balance between efficacy and toxicity.

  4. These alterations in the activities and expression profiles of the GlyTs suggest that the contributions of GlyT1 (zeige GLYT1 ELISA Kits) and GlyT2 to the regulation of extracellular glycine concentrations at glycinergic synapses changes during development.

  5. Data show that the GlyT2 protein is undetectable in homozygous mutants, indicating a null allele.

  6. In the first postnatal week, loss of the glycine transporter 2 is neither compensated by glycine de-novo synthesis nor by up-regulation of the GABAergic transmission in GlyT2(-/-) mice.

  7. These data indicate that the C-terminal PDZ (zeige INADL ELISA Kits)-ligand motif of GlyT2 plays an important role in transporter trafficking to and/or stabilization at synaptic sites.

  8. Glyt2-mediated release of glycine from axon terminals involves exocytosis triggered by intraterminal mitochondrial Ca2 (zeige CA2 ELISA Kits)+ ions.

  9. our results demonstrate the central role played by GlyT2 in determining inhibitory phenotype and therefore in the physiology and pathology of inhibitory circuits.

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 5 (SLC6A5) Interaktionspartner

  1. analysis of the human SLC6A5 (zeige SLC6A2 ELISA Kits) gene mutation associated with hyperekplexia

  2. Report that in the presence of a GlyT2 mechanism-based toxicity, reversible inhibitors might allow a tolerable balance between efficacy and toxicity.

  3. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster.

  4. A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2.

  5. This study firmly establishes the combination of missense, nonsense, frameshift, and splice site mutations in the GlyT2 gene as the second major cause of startle disease.

  6. A transgenic cell line is studied in which green fluorescent protein (GFP) is expressed under the control of the promoter for the glycine transporter GlyT2 during zebrafish development.

  7. Inspiratory-modulated neurons with pacemaker properties are present in the preBotzinger complex of newborn transgenic mice and express the glycine tranporter (GlyT)2 protein.

  8. SLC6A5 (zeige SLC6A2 ELISA Kits) mutations result in defective subcellular GlyT2 localization, decreased glycine uptake or both, with selected mutations affecting predicted glycine and Na+ binding sites.

  9. results are consistent with GLYT2 being a disease gene in human hyperekplexia

  10. SLC6A5 (zeige SLC6A2 ELISA Kits) gene is associated with schizophrenia.

SLC6A5 Antigen-Profil

Beschreibung des Gens

This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia\; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea.

Genbezeichner und Symbole assoziert mit SLC6A5

  • solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (SLC6A5) Antikörper
  • solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (LOC100339626) Antikörper
  • solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (Slc6a5) Antikörper
  • solute carrier family 6 (neurotransmitter transporter), member 5 (SLC6A5) Antikörper
  • solute carrier family 6 (neurotransmitter transporter), member 5 (Slc6a5) Antikörper
  • GLYT-2 Antikörper
  • GLYT2 Antikörper
  • HKPX3 Antikörper
  • NET1 Antikörper
  • prestin Antikörper
  • SLC6A5 Antikörper

Bezeichner auf Proteinebene für SLC6A5

solute carrier family 6 (neurotransmitter transporter, glycine), member 5 , sodium- and chloride-dependent glycine transporter 2-like , glyT-2 , glycine transporter 2 , sodium- and chloride-dependent glycine transporter 2 , solute carrier family 6 member 5

GENE ID SPEZIES
422974 Gallus gallus
466470 Pan troglodytes
612095 Canis lupus familiaris
704703 Macaca mulatta
100339626 Oryctolagus cuniculus
100431924 Pongo abelii
100585180 Nomascus leucogenys
104245 Mus musculus
9152 Homo sapiens
171148 Rattus norvegicus
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