anti-Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 1 (SLC6A1) Antikörper

The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Maus SLC6A1 SLC6A1 232333 P31648
Anti-Ratte SLC6A1 SLC6A1 79212 P23978
Anti-Human SLC6A1 SLC6A1 6529 P30531
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Weitere Antikörper gegen Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 1 Interaktionspartner

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 1 (SLC6A1) Interaktionspartner

  1. Results demonstrated that GAT-1-/- mice have phenotypes of hyperactivity, impaired sustained attention and learning deficiency, and the performance of GAT-1-/- mice is similar to ADHD symptoms.

  2. Results suggest that the excessive GAT-1 and GlyT-1 (zeige GLYT1 Antikörper)/2 heterotransporter-mediated Glu (zeige GCG Antikörper) release, in the spinal cord of SOD1 (zeige SOD1 Antikörper)(G93A) mice, is due to the heterotransporter over-expression at the nerve terminal membrane, promoted by the excessive Glu (zeige GCG Antikörper) exocytosis

  3. Results demonstrate that high-affinity activation by GABA of GAT1 transporters provokes release of [3H]GABA from nerve terminals by different mechanisms

  4. these data show that during paclitaxel-induced neuropathic pain there is significant increase in GAT-1 expression in the ACC. GAT-1 is the main transporter of GABA from the synapse

  5. Development of GABA-removal system and its relationship to development of GABAergic networks studied by examination of changes in GAT-1 and GAT-3 (zeige SLC6A13 Antikörper) expression and localization in embryonic and postnatal mouse spinal cord

  6. GAT1 plays a critical role in the regulation of rapid eye movement (REM (zeige REM1 Antikörper)) sleep and homeostasis of non-REM (zeige REM1 Antikörper) sleep.

  7. results suggest that GAT1 ko mouse is a new animal model for ADHD studying and GAT1 may be a new target to treat ADHD

  8. We failed to provide proof-of-concept evidence that lower PV and GAT1 expression in schizophrenia are a consequence of lower GAD67 (zeige GAD1 Antikörper) expression

  9. Results suggest that a moderate reduction in GAT1 activity causes the enhancement of learning and memory in mice.

  10. the terminal sialic acid of N-linked oligosaccharides of GAT1 plays a crucial role in the gamma aminobutyric acid transport process

Human Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 1 (SLC6A1) Interaktionspartner

  1. the "extra" residue in transmembrane domain 10 of the GABA transporter GAT-1 provides extra bulk, probably in the form of a pi-helix, which is required for stringent gating and tight coupling of ion and substrate fluxes in the GABA transporter family.

  2. Results show that SLC6A1 minor genotypes/alleles were protective against risk for alcoholism in 3 ethnically diverse cohorts.

  3. Genome-wide significant associations were highly biological plausible, including associations within GABA transporter 1, SLC6A1 (solute carrier (zeige SERTAD2 Antikörper) family 6, member 1), and exonic hits in LOC100129340 (mitofusin-1 (zeige MFN1 Antikörper)-like

  4. targeted resequencing of 644 individuals with epileptic encephalopathies led to the identification of six SLC6A1 mutations in seven individuals, all of whom have epilepsy with myoclonic-atonic seizures (MAE).

  5. 3p25.3 microdeletion of GABA transporters SLC6A1 and SLC6A11 (zeige SLC6A11 Antikörper) results in intellectual disability, epilepsy and stereotypic behavior.

  6. Cysteine mutagenesis of GAT-1 pointed to conformationally sensitive proximity of extracellular loops 2 and 4 in this protein.

  7. The aromatic and charge pairs of the thin extracellular gate of the GABA transporter GAT-1 are differently impacted by mutation.

  8. a functional interaction of the external and internal gates of GAT-1 is essential for transport

  9. TM10 of GAT-1 lines an accessibility pathway from the extracellular space into the binding pocket and plays a role in the opening and closing of the extracellular transporter gate.

  10. GABA Transporter Mutagenesis Database (GATMD), a web-accessible, relational database of manually annotated biochemical, functional and pharmacological data reported on GAT1.

Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 1 (SLC6A1) Antigen-Profil

Protein Überblick

The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009

Genbezeichner und Symbole assoziert mit SLC6A1

  • GABA neurotransmitter transporter 1 (slc6a1) Antikörper
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 1 (Slc6a1) Antikörper
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 1 (SLC6A1) Antikörper
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 1, like (slc6a1l) Antikörper
  • solute carrier family 6 (neurotransmitter transporter), member 1 (Slc6a1) Antikörper
  • solute carrier family 6 (neurotransmitter transporter), member 1 (SLC6A1) Antikörper
  • A730043E01 Antikörper
  • GABATHG Antikörper
  • GABATR Antikörper
  • Gabt Antikörper
  • Gabt1 Antikörper
  • GAT-1 Antikörper
  • GAT1 Antikörper
  • si:ch211-280e18.1 Antikörper
  • si:dkey-164m14.1 Antikörper
  • slc6a1 Antikörper
  • XT-1 Antikörper
  • Xtrp1 Antikörper

Bezeichner auf Proteinebene für SLC6A1

gamma-aminobutyric acid (GABA-A) transporter 1 , sodium- and chloride-dependent GABA transporter 1 , solute carrier family 6 member 1 , GABA transporter GAT-1 homolog , GABA transporter protein , GAT-1 , solute carrier family 6 (neurotransmitter transporter, GABA), member 1 , GABA transporter 1

GENE ID SPEZIES
734186 Xenopus laevis
232333 Mus musculus
415960 Gallus gallus
484655 Canis lupus familiaris
407118 Bos taurus
568985 Danio rerio
79212 Rattus norvegicus
6529 Homo sapiens
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