Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 2 Proteine (SLC5A2)

SLC5A2 encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. Zusätzlich bieten wir Ihnen SLC5A2 Antikörper (43) und SLC5A2 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC5A2 6524 P31639
SLC5A2 246787 Q923I7
Ratte SLC5A2 SLC5A2 64522 P53792
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 5 bis 7 Tage
324,01 €
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SLC5A2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) ,
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Weitere Proteine zu Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 2 (SLC5A2) Interaktionspartnern

Cow (Bovine) Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 2 (SLC5A2) Interaktionspartner

  1. cloning and distribution of SGLT2 mRNA expression in bovine tissues; SGLT2 mRNA was detected predominantly in the kidney; expression of SGLT2 mRNA in mammary gland increased more than 10-fold from late pregnancy to early lactation

Human Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 2 (SLC5A2) Interaktionspartner

  1. Results provide evidence that common genetic variants in the SLC5A2 gene do not affect diabetes-related metabolic traits in subjects at increased risk of type 2 diabetes.

  2. SGLT2/MAP17 (zeige PDZK1IP1 Proteine) functions as a low-affinity Na(+)-glucose cotransporter (zeige SLC5A1 Proteine) in the kidney.

  3. reported nominal effects of individual SLC5A2 variants on fasting and post-challenge glucose levels may probably not be mediated by altered glucagon (zeige GCG Proteine) release

  4. Findings suggest that there are subtypes of T2DM characterized by different urinary glucose excretion and cardiovascular risk factors. SLC5A2 and HNF1A (zeige HNF1A Proteine) mutations partially explain renal glycosuria in patients with T2DM.

  5. SGLT2 inhibitors combined with insulin (zeige INS Proteine) might be an efficient and safe treatment modality for T1DM patients.

  6. Data suggest that, by shunting substantial amounts of carbohydrate into urine, SGLT2-mediated glycosuria results in a progressive shift in energy metabolism toward fatty substrates; studies were conducted in subjects with/without diabetes type 2 treated with SGLT2 antagonist and hypoglycemic agent empagliflozin.

  7. Studies indicate that Sodium-glucose cotransporter 2 (SGLT2)T2 inhibitors are promising antidiabetic agents that are gaining attention in both clinical medicine and basic research.

  8. Data suggest that ketoacidosis (ketonuria/ketonemia) associated with the use of sodium-glucose cotransporter 2 protein (SGLT-2) inhibitors needs further research.

  9. In both men and women, grip strength increased in both hands after sodium-glucose cotransporter 2 protein (SGLT2) inhibitor treatment .

  10. Data suggest that SGLT2 plays central role in energy metabolism and renal elimination of circulating glucose; targeted inhibition of SGLT2 alters energy metabolism in diabetes and obesity.

Mouse (Murine) Solute Carrier Family 5 (Sodium/glucose Cotransporter), Member 2 (SLC5A2) Interaktionspartner

  1. Tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, suppress albuminuria and tubulointerstitial injury in obese and type 2 diabetic mice. Inhibition of glucose entry into tubular cells by tofogliflozin may exert renoprotective properties in diabetes.

  2. SGLT2 inhibition induced gluconeogenesis mainly in the kidney, whereas for low carbohydrate diet, it was predominantly in the liver.

  3. Suggest SGLT2 inhibitor pragliflozin may be effective when administered as part of a combination regimen in the treatment of type 2 diabetes.

  4. these results suggest that SGLT2i treatment acutely suppresses energy expenditure in BAT (zeige BAAT Proteine) via regulation of an inter-organ neural network consisting of the common hepatic vagal branch and sympathetic nerves.

  5. In conclusion, SGLT2 inhibitor luseogliflozin ameliorates glycemic control and thus exerts protective effects on pancreatic beta-cell mass and function.

  6. SGLT2 can transport gentamicin and contribute to gentamicin-induced cytotoxicity.

  7. SGLT2 is inhibited with dapagliflozin in pancreatic alpha cells, which triggers glucagon (zeige GCG Proteine) secretion

  8. DNA sequencing of SGLT2 in SAMP10/TaSlc mice revealed a single nucleotide deletion of guanine at 1236, which resulted in a frameshift mutation that produced a truncated protein.

  9. Improved glycemic control in mice lacking Sglt1 (zeige SLC5A1 Proteine) and Sglt2.

  10. Prevention of renal glucose reabsorption by SGLT2 deletion reduced hyperglycemia, improved glucose intolerance, and increased glucose-stimulated insulin (zeige INS Proteine) secretion in vivo.

SLC5A2 Protein Überblick

Protein Überblick

This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria.

Genbezeichner und Symbole assoziert mit SLC5A2

  • solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2)
  • solute carrier family 5 (sodium/glucose cotransporter), member 2 (slc5a2)
  • solute carrier family 5 (sodium/glucose cotransporter), member 2 (Slc5a2)
  • DKFZp469E0433 Protein
  • MGC83377 Protein
  • Sglt2 Protein
  • slc5a2 Protein
  • zgc:85792 Protein

Bezeichner auf Proteinebene für SLC5A2

sodium/glucose cotransporter 2 , solute carrier family 5 (sodium/glucose cotransporter), member 2 , Na(+)/glucose cotransporter 2 , low affinity sodium-glucose cotransporter , solute carrier family 5 (sodium/glucose transporter), member 2 , solute carrier family 5 member 2 , low affinity sodium-dependent glucose cotransporter , low affinity Na-dependent glucose transporter (SGLT2) , Na(+)/nucleoside cotransporter , Na+/nucleoside cotransporter , sodium/nucleoside cotransporter

GENE ID SPEZIES
399680 Bos taurus
714228 Macaca mulatta
100136139 Oncorhynchus mykiss
100172191 Pongo abelii
405862 Danio rerio
447523 Xenopus laevis
100380144 Xenopus (Silurana) tropicalis
6524 Homo sapiens
246787 Mus musculus
64522 Rattus norvegicus
100009386 Oryctolagus cuniculus
Ausgewählte Anbieter für SLC5A2 Proteine (SLC5A2)
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